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View Structure Prediction Details

Protein: phl-PB
Organism: Drosophila melanogaster
Length: 782 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for phl-PB.

Description E-value Query
Range
Subject
Range
gi|2144415 - gi|2144415|pir||TVFFDF protein kinase Draf-1 (EC 2.7.1.-) - fruit fly (Drosophila melanogaster)
617.0 [0..1] [782..1]

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Predicted Domain #1
Region A:
Residues: [1-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSESSTEGD SDLYDPLAEE LHNVQLVKHV TRENIDALNA KFANLQEPPA MYLIGESSKA  60
   61 ELNTTWVLGN PTPTSKLFIK YPTYVYVCIS RLWFLPTEYQ ELTSKLHELE AKEQELMERL 120
  121 NSQDQQEDSS LVERFKEQPH YQNQTQILQQ QRQLARVHHG NDLTDSLGSQ PGSQCGTLTR 180
  181 QPKILLRAHL PNQQRTSVEV ISGVRLCDAL MKALKLRQLT PDMCEVSTTH SGRHIIPWHT 240
  241 DIGTLHVEEI FVRLLDKFPI RTHIKHQIIR KTFFSLVFCE GCRRLLFTGF YCSQCNFRFH 300
  301 QRCANRVPML CQPFPMDSYY QLLLAENPDN GVGFPGRGTA VRFNMSSRSR SRRCSSSGSS 360
  361 SSSKPPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
epidermal growth factor receptor binding 2.9751846707539 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
insulin receptor binding 2.73485644242393 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.76952905409847 bayes_pls_golite062009
protein kinase activity 1.62921423829738 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.52843393025918 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
transcription regulator activity 1.08577758274384 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
protein complex binding 0.65988681496356 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.649814096718101 bayes_pls_golite062009
nucleic acid binding 0.604021689968387 bayes_pls_golite062009
DNA binding 0.418154636457321 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009
protein tyrosine kinase activity 0.206747304356052 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.169458153875562 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
cytokine receptor binding 0.16478124520484 bayes_pls_golite062009
kinase regulator activity 0.10704587503284 bayes_pls_golite062009
receptor signaling protein activity 0.0443241110585009 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [368-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGNHRQGR PPRISQDDRS NSAPNVCINN IRSVTSEVQR SLIMQARPPL PHPCTDHSNS  60
   61 TQASPTSTLK HNRPRARSAD ES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [450-782]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNLLLRDAK SSEENWNILA EEILIGPRIG SGSFGTVYRA HWHGPVAVKT LNVKTPSPAQ  60
   61 LQAFKNEVAM LKKTRHCNIL LFMGCVSKPS LAIVTQWCEG SSLYKHVHVS ETKFKLNTLI 120
  121 DIGRQVAQGM DYLHAKNIIH RDLKSNNIFL HEDLSVKIGD FGLATAKTRW SGEKQANQPT 180
  181 GSILWMAPEV IRMQELNPYS FQSDVYAFGI VMYELLAECL PYGHISNKDQ ILFMVGRGLL 240
  241 RPDMSQVRSD APQALKRLAE DCIKYTPKDR PLFRPLLNML ENMLRTLPKI HRSASEPNLT 300
  301 QSQLQNDEFL YLPSPKTPVN FNNFQFFGSA GNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.30103
Match: 2fb8A
Description: No description for 2fb8A was found.

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Created and Maintained by: Michael Riffle