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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad50. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 7 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • MKT1
  • polysome
  • cytoplasm
  • interspecies interaction between organisms
  • positive regulation of translation
  • nuclease activity
  • MRE11
  • nucleus
  • mitochondrion
  • Mre11 complex
  • DNA repair
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • meiotic DNA double-strand break formation
  • adenylate kinase activity
  • 3'-5' exonuclease activity
  • protein binding
  • telomeric DNA binding
  • endonuclease activity
  • endodeoxyribonuclease activity
  • RAD50
  • nucleus
  • mitochondrion
  • Mre11 complex
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • telomere maintenance via recombination
  • double-strand break repair via nonhomologous end joining
  • meiosis
  • meiotic DNA double-strand break formation
  • ATPase activity
  • adenylate kinase activity
  • protein binding
  • telomeric DNA binding
  • double-stranded DNA binding
  • VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • XRS2
  • nucleus
  • Mre11 complex
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • sporulation resulting in formation of a cellular spore
  • meiotic DNA double-strand break formation
  • DNA binding
  • protein binding
  • telomeric DNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Mre11 complex 8.4345E-10 7 3 3 6292
    proton-transporting V-type ATPase, V1 domain 8.8705E-3 7 8 1 6292
    vacuolar proton-transporting V-type ATPase, V1 domain 8.8705E-3 7 8 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-strand break repair via break-induced replication 7.0647E-8 7 9 3 6292
    meiotic DNA double-strand break formation 1.3864E-7 7 11 3 6292
    double-strand break repair via homologous recombination 1.2872E-6 7 22 3 6292
    double-strand break repair via nonhomologous end joining 1.9197E-6 7 25 3 6292
    recombinational repair 2.169E-6 7 26 3 6292
    meiotic DNA double-strand break processing 3.1815E-6 7 3 2 6292
    non-recombinational repair 4.973E-6 7 34 3 6292
    DNA catabolic process, exonucleolytic 1.0594E-5 7 5 2 6292
    DNA double-strand break processing 1.0594E-5 7 5 2 6292
    nucleic acid phosphodiester bond hydrolysis 1.2543E-5 7 46 3 6292
    double-strand break repair 2.405E-5 7 57 3 6292
    meiosis I 6.4316E-5 7 79 3 6292
    DNA catabolic process 1.1065E-4 7 15 2 6292
    DNA recombination 1.923E-4 7 114 3 6292
    homeostatic process 5.2115E-4 7 408 4 6292
    meiosis 5.2397E-4 7 160 3 6292
    M phase of meiotic cell cycle 5.2397E-4 7 160 3 6292
    meiotic cell cycle 5.6343E-4 7 164 3 6292
    DNA repair 8.9429E-4 7 192 3 6292
    response to DNA damage stimulus 1.6304E-3 7 236 3 6292
    regulation of biological quality 1.6425E-3 7 551 4 6292
    interspecies interaction between organisms 2.224E-3 7 2 1 6292
    anatomical structure homeostasis 2.8379E-3 7 286 3 6292
    telomere organization 2.8379E-3 7 286 3 6292
    telomere maintenance 2.8379E-3 7 286 3 6292
    cellular response to stress 2.9533E-3 7 290 3 6292
    M phase 3.0716E-3 7 294 3 6292
    macromolecule catabolic process 3.0716E-3 7 294 3 6292
    biological regulation 3.9225E-3 7 1213 5 6292
    positive regulation of translation 4.4437E-3 7 4 1 6292
    response to stimulus 5.631E-3 7 766 4 6292
    cell cycle phase 6.1847E-3 7 376 3 6292
    cellular response to stimulus 6.3249E-3 7 379 3 6292
    positive regulation of cellular protein metabolic process 7.7654E-3 7 7 1 6292
    glycogen catabolic process 7.7654E-3 7 7 1 6292
    positive regulation of protein metabolic process 8.8705E-3 7 8 1 6292
    glucan catabolic process 8.8705E-3 7 8 1 6292
    cellular polysaccharide catabolic process 9.9746E-3 7 9 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    telomeric DNA binding 1.8476E-7 7 12 3 6292
    adenylate kinase activity 6.3596E-6 7 4 2 6292
    nucleotide kinase activity 1.5882E-5 7 6 2 6292
    sequence-specific DNA binding 1.6164E-5 7 50 3 6292
    phosphotransferase activity, phosphate group as acceptor 5.8081E-5 7 11 2 6292
    nucleobase, nucleoside, nucleotide kinase activity 6.966E-5 7 12 2 6292
    glycogen phosphorylase activity 1.1125E-3 7 1 1 6292
    phosphorylase activity 1.1125E-3 7 1 1 6292
    DNA binding 2.0628E-3 7 256 3 6292

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    Created and Maintained by: Michael Riffle