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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    HSH155
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • mRNA binding
    		•
    LUC7
  • U1 snRNP
    		•
  • mRNA splice site selection
    		•
  • mRNA binding
    		•
    PRP39
  • commitment complex
  • U1 snRNP
    		•
  • nuclear mRNA 5'-splice site recognition
    		•
  • pre-mRNA 5'-splice site binding
    		•
    PRP40
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    RSE1
  • U2 snRNP
    		•
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
    		•
  • U2 snRNA binding
    		•
    SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•
    SNU71
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    STO1
  • commitment complex
  • nuclear cap binding complex
    		•
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    small nuclear ribonucleoprotein complex 4.3287E-24 13 63 12 6292
    U1 snRNP 5.1256E-19 13 17 8 6292
    ribonucleoprotein complex 6.2692E-15 13 514 13 6292
    U5 snRNP 5.9483E-14 13 14 6 6292
    U4/U6 x U5 tri-snRNP complex 1.7643E-11 13 32 6 6292
    nuclear part 1.3925E-10 13 1103 13 6292
    commitment complex 5.3753E-9 13 12 4 6292
    U2-type spliceosomal complex 5.3753E-9 13 12 4 6292
    macromolecular complex 2.3774E-8 13 1635 13 6292
    nucleus 4.29E-7 13 2041 13 6292
    spliceosomal complex 1.5578E-6 13 45 4 6292
    organelle part 1.8381E-6 13 2282 13 6292
    intracellular organelle part 1.8381E-6 13 2282 13 6292
    U2 snRNP 3.0349E-4 13 13 2 6292
    membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    nuclear cap binding complex 6.1865E-3 13 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 1.61E-24 13 99 13 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.8506E-24 13 100 13 6292
    RNA splicing, via transesterification reactions 4.7145E-24 13 107 13 6292
    RNA splicing 8.3842E-23 13 132 13 6292
    mRNA processing 8.1015E-22 13 156 13 6292
    mRNA metabolic process 5.3435E-20 13 213 13 6292
    RNA processing 1.17E-16 13 380 13 6292
    RNA metabolic process 2.0874E-11 13 954 13 6292
    gene expression 1.0037E-9 13 1283 13 6292
    nucleic acid metabolic process 3.6054E-9 13 1415 13 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3544E-8 13 1566 13 6292
    spliceosome assembly 3.3001E-8 13 18 4 6292
    cellular nitrogen compound metabolic process 6.6927E-8 13 1770 13 6292
    nitrogen compound metabolic process 7.8058E-8 13 1791 13 6292
    ribonucleoprotein complex assembly 7.0307E-7 13 92 5 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    cellular macromolecular complex assembly 2.0432E-5 13 182 5 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    mRNA splice site selection 5.8841E-5 13 6 2 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    cellular macromolecular complex subunit organization 1.1152E-4 13 259 5 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    macromolecular complex assembly 1.6416E-4 13 281 5 6292
    macromolecular complex subunit organization 5.0375E-4 13 357 5 6292
    ribonucleoprotein complex biogenesis 6.2467E-4 13 374 5 6292
    cellular component assembly 7.1393E-4 13 385 5 6292
    nuclear mRNA 5'-splice site recognition 2.0661E-3 13 1 1 6292
    nuclear mRNA cis splicing, via spliceosome 6.1865E-3 13 3 1 6292
    generation of catalytic spliceosome for first transesterification step 6.1865E-3 13 3 1 6292
    cellular component biogenesis 9.7186E-3 13 694 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 1.61E-14 13 367 12 6292
    nucleic acid binding 2.1259E-11 13 666 12 6292
    mRNA binding 3.1511E-11 13 35 6 6292
    binding 5.799E-8 13 1294 12 6292
    snRNA binding 3.9273E-5 13 5 2 6292
    pre-mRNA 5'-splice site binding 2.0661E-3 13 1 1 6292
    U2 snRNA binding 2.0661E-3 13 1 1 6292
    U5 snRNA binding 4.1283E-3 13 2 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle