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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NOP53
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.6409E-17 12 101 10 6292
    cytosolic part 3.3087E-16 12 122 10 6292
    ribosomal subunit 2.1309E-14 12 183 10 6292
    cytosol 1.8332E-12 12 284 10 6292
    ribosome 2.263E-12 12 290 10 6292
    cytosolic large ribosomal subunit 3.8179E-12 12 60 7 6292
    large ribosomal subunit 3.037E-10 12 110 7 6292
    ribonucleoprotein complex 6.9243E-10 12 514 10 6292
    non-membrane-bounded organelle 1.0154E-8 12 959 11 6292
    intracellular non-membrane-bounded organelle 1.0154E-8 12 959 11 6292
    cytosolic small ribosomal subunit 4.3074E-5 12 38 3 6292
    macromolecular complex 5.3141E-5 12 1635 10 6292
    organelle part 1.1283E-4 12 2282 11 6292
    intracellular organelle part 1.1283E-4 12 2282 11 6292
    small ribosomal subunit 3.0582E-4 12 73 3 6292
    cytoplasmic part 2.4627E-3 12 2482 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 3.4314E-13 12 376 11 6292
    cellular protein metabolic process 3.482E-8 12 1074 11 6292
    protein metabolic process 6.4045E-8 12 1136 11 6292
    cellular macromolecule biosynthetic process 1.0311E-7 12 1187 11 6292
    macromolecule biosynthetic process 1.0501E-7 12 1189 11 6292
    gene expression 2.393E-7 12 1283 11 6292
    cellular biosynthetic process 2.065E-6 12 1567 11 6292
    biosynthetic process 2.6176E-6 12 1602 11 6292
    cellular macromolecule metabolic process 1.144E-4 12 2285 11 6292
    macromolecule metabolic process 1.5296E-4 12 2349 11 6292
    ribosomal small subunit biogenesis 1.0566E-3 12 26 2 6292
    primary metabolic process 1.3504E-3 12 2896 11 6292
    response to cycloheximide 1.9072E-3 12 1 1 6292
    response to cycloalkane 1.9072E-3 12 1 1 6292
    response to organic cyclic substance 1.9072E-3 12 1 1 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292
    ribosome biogenesis 3.1264E-3 12 346 4 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    ribonucleoprotein complex biogenesis 4.1497E-3 12 374 4 6292
    ribosomal subunit assembly 4.6816E-3 12 55 2 6292
    regulation of translation 5.0209E-3 12 57 2 6292
    response to antibiotic 5.7116E-3 12 3 1 6292
    posttranscriptional regulation of gene expression 5.7327E-3 12 61 2 6292
    ribosome assembly 6.2953E-3 12 64 2 6292
    regulation of cellular protein metabolic process 7.0833E-3 12 68 2 6292
    organelle assembly 7.2871E-3 12 69 2 6292
    regulation of protein metabolic process 8.3454E-3 12 74 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 5.7344E-16 12 212 11 6292
    structural molecule activity 1.0864E-13 12 339 11 6292
    rRNA binding 3.9428E-4 12 16 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle