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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CSN12
  • signalosome
    		•
  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
    		•
  • molecular_function
    		•
    CUS1
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • RNA binding
  • protein binding
    		•
    DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    HSH155
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • mRNA binding
    		•
    LEA1
  • cytoplasm
  • U2 snRNP
    		•
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP4
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP6
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • binding
  • molecular_function
    		•
    PRP9
  • U2 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    RSE1
  • U2 snRNP
    		•
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
    		•
  • U2 snRNA binding
    		•
    SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•
    SNU71
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    small nuclear ribonucleoprotein complex 3.0074E-23 14 63 12 6292
    ribonucleoprotein complex 8.1265E-14 14 514 13 6292
    nuclear part 2.4173E-11 14 1103 14 6292
    U4/U6 x U5 tri-snRNP complex 3.0766E-11 14 32 6 6292
    U2 snRNP 3.1104E-11 14 13 5 6292
    macromolecular complex 6.1412E-9 14 1635 14 6292
    nucleus 1.3856E-7 14 2041 14 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    U5 snRNP 3.1472E-6 14 14 3 6292
    U1 snRNP 6.135E-4 14 17 2 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 2.2254E-23 14 99 13 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.5575E-23 14 100 13 6292
    RNA splicing, via transesterification reactions 6.5085E-23 14 107 13 6292
    RNA splicing 1.1531E-21 14 132 13 6292
    mRNA processing 1.1102E-20 14 156 13 6292
    mRNA metabolic process 7.2596E-19 14 213 13 6292
    RNA processing 1.5491E-15 14 380 13 6292
    RNA metabolic process 2.5156E-10 14 954 13 6292
    gene expression 1.1412E-8 14 1283 13 6292
    nucleic acid metabolic process 4.0011E-8 14 1415 13 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4606E-7 14 1566 13 6292
    cellular nitrogen compound metabolic process 6.9352E-7 14 1770 13 6292
    nitrogen compound metabolic process 8.0547E-7 14 1791 13 6292
    spliceosome assembly 7.0183E-6 14 18 3 6292
    cellular macromolecule metabolic process 1.7382E-5 14 2285 13 6292
    macromolecule metabolic process 2.456E-5 14 2349 13 6292
    ribonucleoprotein complex assembly 3.8312E-5 14 92 4 6292
    primary metabolic process 3.2929E-4 14 2896 13 6292
    cellular macromolecular complex assembly 5.401E-4 14 182 4 6292
    cellular metabolic process 5.8003E-4 14 3033 13 6292
    metabolic process 9.4511E-4 14 3157 13 6292
    cellular macromolecular complex subunit organization 2.0249E-3 14 259 4 6292
    macromolecular complex assembly 2.7315E-3 14 281 4 6292
    macromolecular complex subunit organization 6.4746E-3 14 357 4 6292
    generation of catalytic spliceosome for first transesterification step 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292
    ribonucleoprotein complex biogenesis 7.6331E-3 14 374 4 6292
    cellular component assembly 8.4529E-3 14 385 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 3.2847E-10 14 367 10 6292
    nucleic acid binding 1.1164E-7 14 666 10 6292
    binding 5.264E-6 14 1294 11 6292
    snRNA binding 4.5804E-5 14 5 2 6292
    U2 snRNA binding 2.225E-3 14 1 1 6292
    U5 snRNA binding 4.4455E-3 14 2 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle