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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.2764E-17 16 101 11 6292
    cytosolic part 3.7174E-16 16 122 11 6292
    ribosomal subunit 3.5981E-14 16 183 11 6292
    ribonucleoprotein complex 2.787E-12 16 514 13 6292
    cytosol 4.6826E-12 16 284 11 6292
    ribosome 5.8907E-12 16 290 11 6292
    cytosolic large ribosomal subunit 5.3537E-11 16 60 7 6292
    large ribosomal subunit 4.1407E-9 16 110 7 6292
    90S preribosome 6.5086E-8 16 17 4 6292
    preribosome 1.2357E-6 16 34 4 6292
    cytosolic small ribosomal subunit 1.9548E-6 16 38 4 6292
    non-membrane-bounded organelle 2.0406E-6 16 959 11 6292
    intracellular non-membrane-bounded organelle 2.0406E-6 16 959 11 6292
    macromolecular complex 5.8554E-6 16 1635 13 6292
    small ribosomal subunit 2.7318E-5 16 73 4 6292
    organelle part 8.3508E-3 16 2282 11 6292
    intracellular organelle part 8.3508E-3 16 2282 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.9504E-20 16 376 16 6292
    cellular protein metabolic process 4.7313E-13 16 1074 16 6292
    protein metabolic process 1.1685E-12 16 1136 16 6292
    cellular macromolecule biosynthetic process 2.3702E-12 16 1187 16 6292
    macromolecule biosynthetic process 2.4353E-12 16 1189 16 6292
    gene expression 8.2892E-12 16 1283 16 6292
    cellular biosynthetic process 2.0673E-10 16 1567 16 6292
    biosynthetic process 2.9487E-10 16 1602 16 6292
    cellular macromolecule metabolic process 8.851E-8 16 2285 16 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    regulation of translation 2.0658E-7 16 57 5 6292
    posttranscriptional regulation of gene expression 2.918E-7 16 61 5 6292
    regulation of cellular protein metabolic process 5.0607E-7 16 68 5 6292
    regulation of protein metabolic process 7.7519E-7 16 74 5 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    cellular metabolic process 8.3256E-6 16 3033 16 6292
    ribosomal subunit assembly 8.7997E-6 16 55 4 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    ribosome assembly 1.6169E-5 16 64 4 6292
    organelle assembly 2.1831E-5 16 69 4 6292
    ribonucleoprotein complex assembly 6.8113E-5 16 92 4 6292
    ribosome biogenesis 1.3245E-4 16 346 6 6292
    ribonucleoprotein complex biogenesis 2.037E-4 16 374 6 6292
    rRNA processing 2.4604E-4 16 128 4 6292
    rRNA metabolic process 3.1944E-4 16 137 4 6292
    maturation of SSU-rRNA 4.0219E-4 16 59 3 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4.6527E-4 16 13 2 6292
    ribosomal small subunit assembly 5.4201E-4 16 14 2 6292
    cellular macromolecular complex assembly 9.3841E-4 16 182 4 6292
    ncRNA processing 1.7455E-3 16 215 4 6292
    ribosomal small subunit biogenesis 1.9016E-3 16 26 2 6292
    response to cycloalkane 2.5429E-3 16 1 1 6292
    response to organic cyclic substance 2.5429E-3 16 1 1 6292
    negative regulation of mRNA processing 2.5429E-3 16 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 2.5429E-3 16 1 1 6292
    negative regulation of RNA splicing 2.5429E-3 16 1 1 6292
    response to cycloheximide 2.5429E-3 16 1 1 6292
    ncRNA metabolic process 3.3543E-3 16 257 4 6292
    cellular macromolecular complex subunit organization 3.4498E-3 16 259 4 6292
    cellular process 3.565E-3 16 4426 16 6292
    regulation of gene expression 3.9309E-3 16 445 5 6292
    regulation of macromolecule biosynthetic process 4.3701E-3 16 456 5 6292
    macromolecular complex assembly 4.6277E-3 16 281 4 6292
    ribosomal large subunit assembly 4.6924E-3 16 41 2 6292
    regulation of cellular biosynthetic process 5.0714E-3 16 472 5 6292
    regulation of mRNA processing 5.0798E-3 16 2 1 6292
    regulation of RNA splicing 5.0798E-3 16 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 5.0798E-3 16 2 1 6292
    regulation of biosynthetic process 5.1178E-3 16 473 5 6292
    cellular component biogenesis 5.3341E-3 16 694 6 6292
    regulation of macromolecule metabolic process 5.8511E-3 16 488 5 6292
    regulation of primary metabolic process 7.2976E-3 16 514 5 6292
    response to antibiotic 7.6106E-3 16 3 1 6292
    regulation of cellular metabolic process 8.7081E-3 16 536 5 6292
    regulation of metabolic process 9.4817E-3 16 547 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.574E-24 16 212 16 6292
    structural molecule activity 3.587E-21 16 339 16 6292
    rRNA binding 7.1262E-4 16 16 2 6292
    RNA binding 1.6796E-3 16 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle