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Protein Overview: CG7755-PA

General Information:
Name(s) found: CG7755-PA / FBpp0086326 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG7755 (CG7755, FBgn0034105). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12169132..12170451. It has the cytological map location 53A5. Based on sequence similarity, it is predicted to have molecular function</span>: isocitrate dehydrogenase (NAD+) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 378 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: magnesium ion binding [IEA]
    isocitrate dehydrogenase (NAD+) activity [ISS]
    NAD or NADH binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRCPKVTQS MLARISVRHF ADEIHGSVRA AYAKGDARAD PVNVLPKSKY GGINTVSLVT  60
   61 GTTIIGQQGA QFVSSLLSSS RVPVEVQVIE AGQDDEYFHS VLRNRTAVHV DNQADAEAKQ 120
  121 KALKICNDLD LYVFKTRTRS FPGFKCRFPG VDIQLIGQNN MGIFNELEYS PVEGVVEALS 180
  181 VVSQKGNDKY LRYAFKAAAK AGRKRVTLIN KAKEWPISDG SLVEAAQRLH CHYKDCLELE 240
  241 LMEVEEAISR LMTEPTYFDC LFASERYATF LSAICSGVCG GANLFSAVEI GDHHAVFKPL 300
  301 QTKLSLTNYA NLSAYGIVST IVDLFQHLGH DKCADALWCE LKRTMDEGIR TKEFGGQDTG 360
  361 EYVICNIINQ LRCRALGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] PSI-BLAST 93.69897 Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, Thermus thermophilus


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle