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Protein Overview: CG11423-PA

General Information:
Name(s) found: CG11423-PA / FBpp0086012 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG11423 (CG11423, FBgn0034251). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13482772..13484914. It has the cytological map location 54C12. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 702 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex I [ISS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: FMN binding [IEA]
    NAD or NADH binding [IEA]
    NADH dehydrogenase (ubiquinone) activity [ISS]
    4 iron, 4 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISFLLKRRA CDAYKISLGL TRAYRALTEV KSLQNALRPG NKTGNIKLVN IYRTSSIQNV  60
   61 KKNQLSDAES VIPLLLRPAK PVLIMREGSQ TDCNDDLLSS EQRAKKRESI KKSEVDCPKF 120
  121 PAEKLPPTTK FPINENAKKV LDPADQRELE ANLLKRLKDM AKRKKSRLDE KVDELRDNFI 180
  181 GWNYAALQGR TIVTVDAKES TPPKGSGPAT PAGSPPPKNV SAPPTGGSPP AKSGAPPPPK 240
  241 GPPPGTPPPQ TKTTFGPLAD ADRIFTNLYG RHDWRLKAAM KRGDWYKTKE IIAKGDKWIV 300
  301 NEIKTSGLRG RGGAGFPSGL KWSFMHKPPD GRPKFLVVNA DEGEPGTCKD REIMRHDPHK 360
  361 LVEGCLIAGR AMGANTGFIY IRGEFYNEAC NLQYAIIEAY KAGYLGKNAC GSGFDFDLYV 420
  421 QRGAGAYICG EETSLIESLE GKAGKPRNKP PFPADIGVFG CPSTVTNVET VAVSPTICRR 480
  481 GGNWFASFGR TRNSGTKLFN ISGHVCNPCT VEEEMSMPTR ELIERHAGGV IGGWDNLLAI 540
  541 IPGGSSTPCI TKEHASSAIH DYDGLMAVRS SMGTGALIVM NKDTDIIKAI ARLSAFYKHE 600
  601 SCGQCTPCRE GLHWVNMIMH RFVTGQAQIA EIDMLFELTK QIEGHTICAL ADGAAWPPQG 660
  661 LIRNFRPVIE ERIKKRAAED QAKAEALEAE RFPCQTVTPC PE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] deduced N/A No confident structure predictions are available.
    2 View Details [179..256] MSA 1.175987 View MSA. No confident structure predictions are available.
    3 View Details [257..702] PSI-BLAST 157.0 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  13.4136491947011 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  12.443012098477 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  12.1743193111446 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  11.5132141901667 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  10.8948060301507 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.75377893144873 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  3.21486196088149 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  2.15499718507114 bayes_pls_golite062009
  • electron carrier activity
    		•  1.50427278540084 bayes_pls_golite062009
  • catalytic activity
    		•  1.46362311772849 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • metal cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • binding
    		•  1.25265721111105 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor
    		•  0.530794334701446 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.471058486160512 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  0.281674499766589 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  0.281674499766589 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle