Protein Overview: Nf1-PC

General Information:
Name(s) found:	Nf1-PC / FBpp0084327 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|45551977\|ref\|NP_733131.2\| neurofibromin 1, isoform C [Drosophila melanogaster] [NCBI NR] gi\|45446665\|gb\|AAN14067.2\| neurofibromin 1, isoform C [Drosophila melanogaster] [NCBI NR] The gene Neurofibromin 1 is referred to in FlyBase by the symbol Dmel\Nf1 (CG8318, FBgn0015269). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21808735..21820876. It has the cytological map location 96F9. There is experimental evidence that it has the molecular function</span>: Ras GTPase activator activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: regulation of biological process; response to stress; response to chemical stimulus; regulation of multicellular organism growth; regulation of nucleotide metabolic process; memory; Ras protein signal transduction; glial cell growth; olfactory learning; determination of adult lifespan; locomotory behavior; positive regulation of multicellular organism growth. 32 alleles are reported. The phenotypes of these alleles are annotated with: pupa; dorsal mesothoracic disc; surface associated glial cell; embryonic heart; eye photoreceptor cell; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] (AAN14067) CG8318-PC [DrosMelano7227.FASTAC.txt] CG8318-PC, isoform C [Drosophila melanogaster]gi\|45551977\|ref\|NP_733131.2\| CG8318-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:join(21809014..21809070,21809314..21809457,21809557..21809941,21809997..21810138,21810195..21810788,21810850..21811171,21811234..21811786,21811841..21812378,21812434..21814025,21814082..21814688,21814742..21817097,21817153..21817407,2 [fly-100309-contam.fasta] CG8318-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] Neurofibromin 1 CG8318-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:join(21809014..21809070,21809314..21809457,21809557..21809941,21809997..21810138,21810195..21810788,21810850..21811171,21811234..21811786,21811841..21812378,21812434..21814025,21814082..21814688,21814742..21817097,21817153..21817407,21817472..21817567,21818530..21818732,21818795..21818981,21819041..21819206,21820460..21820503); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067; MD5=421367d073089827703323298d0f9317; length=2746; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:join(21809014..21809070,21809314..21809457,21809557..21809941,21809997..21810138,21810195..21810788,21810850..21811171,21811234..21811786,21811841..21812378,21812434..21814025,21814082..21814688,21814742..21817097,21817153..21817407,21817472..21817567,21818530..21818732,21818795..21818981,21819041..21819206,21820460..21820503); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067; MD5=421367d073089827703323298d0f9317; length=2746; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Neurofibromin 1, isoform C OS=Drosophila melanogaster GN=Nf1 PE=4 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3R:join(21809014..21809070,21809314..21809457,21809557..21809941,21809997..21810138,21810195..21810788,21810850..21811171,21811234..21811786,21811841..21812378,21812434..21814025,21814082..21814688,21814742..21817097,21817153..21817407,21817472..21817567,21818530..21818732,21818795..21818981,21819041..21819206,21820460..21820503); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067,FlyMine:FBpp0084327,modMine:FBpp0084327; MD5=421367d073089827703323298d0f9317; length=2746; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:join(25983292..25983348,25983592..25983735,25983835..25984219,25984275..25984416,25984473..25985066,25985128..25985449,25985512..25986064,25986119..25986656,25986712..25988303,25988360..25988966,25989020..25991375,25991431..25991685,25991750..25991845,25992808..25993010,25993073..25993259,25993319..25993484,25994738..25994781); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067,FlyMine:FBpp0084327,modMine:FBpp0084327; MD5=421367d073089827703323298d0f9317; length=2746; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:join(25983292..25983348,25983592..25983735,25983835..25984219,25984275..25984416,25984473..25985066,25985128..25985449,25985512..25986064,25986119..25986656,25986712..25988303,25988360..25988966,25989020..25991375,25991431..25991685,25991750..25991845,25992808..25993010,25993073..25993259,25993319..25993484,25994738..25994781); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067,FlyMine:FBpp0084327,modMine:FBpp0084327; MD5=421367d073089827703323298d0f9317; length=2746; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of Q9VBJ2, Neurofibromin 1, isoform C OS=Drosophila melanogaster GN=Nf1 PE=1 SV=2 [DROME.fasta.20160308] FBpp0084327 type=protein; loc=3R:join(25983292..25983348,25983592..25983735,25983835..25984219,25984275..25984416,25984473..25985066,25985128..25985449,25985512..25986064,25986119..25986656,25986712..25988303,25988360..25988966,25989020..25991375,25991431..25991685,25991750..25991845,25992808..25993010,25993073..25993259,25993319..25993484,25994738..25994781); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067,FlyMine:FBpp0084327,modMine:FBpp0084327; MD5=421367d073089827703323298d0f9317; length=2746; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:join(25983292..25983348,25983592..25983735,25983835..25984219,25984275..25984416,25984473..25985066,25985128..25985449,25985512..25986064,25986119..25986656,25986712..25988303,25988360..25988966,25989020..25991375,25991431..25991685,25991750..25991845,25992808..25993010,25993073..25993259,25993319..25993484,25994738..25994781); ID=FBpp0084327; name=Nf1-PC; parent=FBgn0015269,FBtr0084953; dbxref=FlyBase_Annotation_IDs:CG8318-PC,FlyBase:FBpp0084327,GB_protein:AAN14067.2,REFSEQ:NP_733131,GB_protein:AAN14067,UniProt/TrEMBL:Q8IMS2,FlyMine:FBpp0084327,modMine:FBpp0084327; MD5=421367d073089827703323298d0f9317; length=2746; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2746 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of multicellular organism growth [IMP] determination of adult lifespan [IMP] perineurial glial growth [IGI] regulation of Ras protein signal transduction [IMP] positive regulation of adenylate cyclase activity [IMP] olfactory learning [IMP] Ras protein signal transduction [IGI] positive regulation of multicellular organism growth [IMP] response to oxidative stress [IMP] short-term memory [IMP] response to heat [IMP] locomotor rhythm [IMP] cAMP-mediated signaling [IMP]
Molecular Function:	Ras GTPase activator activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQKPGEWAS ALLARFEDQL PNRIGAYGTQ ARMSQDQLVA CLIHISRYRF SLVISGLTKM  60
   61 LQRVNEAALQ NRHEPERCYF ESLVIILTTL ERCLTNQTKD TARFEEAMNV KLLLREISQF 120
  121 VDVQSDSNPN AAQLKALASK VLFALSQNHF SAVFNRISAR IQELTSCSEE NPDYNDIELI 180
  181 QHIDMDMIKL TKLLQETITK FRSKRAPPLI LLYSLEKAIW NWIEYHPQEF QDLQRGTNRD 240
  241 ISTCWEPLMD FVEYFKTENK KSKTLVWPLQ MLLLILNPSC LEAVVNELQQ SEKEKEKDKE 300
  301 KVASKSAQST SRDKDFSAKQ FIESIKRGLG QHSPSKQVTE SAAIACVKLC KASTYINNTD 360
  361 SNNVVFKLVQ FFINDLKALL FNPAKPFSRG QGYNFADIEL MIDCWVSCFR INPHNIEALK 420
  421 VCLNLSSPQA YHFVIVCSLL RLAHIYVDFR LQNKNPFRIV NQPRLSWWPQ TDVVHYRSAE 480
  481 LRALFTDTLN KATQGYIAHT PLRYITSLTL KSKDTQKGLT RAEEGPAHKM LLLLLVRLIH 540
  541 ADPTLLLNTQ GKVAHEVQSS TLELINGLVS LVHQTTMPDV AQEAMEALLA LHAPEKIEVW 600
  601 NPEAPINTFW DVSSQVLFSI SQKLIQHQIA NYTDVLKWLR EILICRNTFL QRHKDYAHVG 660
  661 SQIAICKQAH IKMEVVFFMY LWSVDLDAVL TSLSCFGLLC EEAEICCSSD ELTVGFIMPN 720
  721 YHIYQELAQL STSATDSRIC FFDNTHGNVL SRLTLQKRIM TLLRKIEHCV HGVQPAWEET 780
  781 FRNWEVSSKV LQTYPKCKGE DGQAEVFHRG MGKRRASHQS SEHDLEEQIN EWANMTWFLL 840
  841 ALGGVCLHKR SSSRQMLLQQ SQNNASLGSL AQNSLYSSST SSGHGSLHPS TVSLSTLPPA 900
  901 PPQDVSYCPV TQFVGQLLRL LVCSNEKIGL NIQKNVKELV GEEMSTQLYP ILFDQVRAIV 960
  961 EKFFDQQGQV NVNVTDINTQ FIEHTIYIMK SILDPKANKD PNNDQPSPSE HLGVTSIEGM1020
 1021 MLGIVRYVRH LDMTVYAIRI KTKLCQLVEV MMKRRDDLAF RQEMKFRNKL VEYLTDWVMG1080
 1081 TSHQIAPPSS ADAAILTNTS LIFRDLDQAC MEAVAALLRG LPLQPEESDR GDLMDAKSAL1140
 1141 FLKYFTLFMN LLNDCIDSSE AEKEMNNTPL LPPRPRMAAG KLTALRNATI LAMSNLLGAN1200
 1201 IDSGLMHSID LGYNPDLQTR AAFMEVLTQI LQQGTEFDTL AETVLADRFE QLVQLVTMIS1260
 1261 DKGELPIAMA LANVVTTSQM DELARVLVTL FDAKHLLSPL LWNMFYREVE VSDCMQTLFR1320
 1321 GNSLGSKIMA FCFKIYGASY LQMLLEPLIR PLLDEEEETC FEVDPARLDP TEDIEQHRNN1380
 1381 LIALTQKVFD AIINSSDRFP PQLRSMCHCL YQVLSKRFPN LLQNNIGAVG TVIFLRFINP1440
 1441 AIVSPQELGI VDKQVHSSAK RGLMLMSKIL QNIANHVEFS KEQHMLCFND FLRDHFEAGR1500
 1501 RFFIQIASDC ETVDQTSHSM SFISDANVLA LHRLLWTHQE KIGDYLSSSR DHKAVGRRPF1560
 1561 DKMATLLAYL GPPEHKPVDS HMMFSSYARW SSIDMSSTNF EEIMVKHQMH EKEEFKTLKS1620
 1621 MNIFYQAGTS KSGYPVFYYI ARRYKIGETN GDLLIYHVIL TLKPFCHSPF EVVIDFTHTC1680
 1681 SDNRFRTEFL QKWFYVLPTV AYENVHAVYI YNCNSWVREY TKFHDRILAP LKGNRKLLFL1740
 1741 ESPNKLTDFI DAEQQKLPGA TLSLDEDLKV FSNALKLSHK DTKVAIKVGP TALQITSAEK1800
 1801 TKVLAHSVLL NDVYYASEIE EVCLVDDNQF TLSITNESGQ LSFIHNDCDN IVQAIIHIRN1860
 1861 RWELSQPDSV TVHQKIRPKD VPGTLLNMAL LNLGSCDPNL RTAAYNLLCA LTATFDLKIE1920
 1921 GQLLETQGLC IPSNNTIFIK SVSEKLATNE PHLTLEFLEE SIQGFQRSTI ELKHLCLEYM1980
 1981 TPWLKNLVKF CKSNDDSKKL KVSQILDKLI NLTIDQKEMY PSVQAKIWGS IGQIPELIDM2040
 2041 VLDNFLHKSI TYGLGSPQVE IMADTAVALA SANVQLVSKK VITRICRVMD KSCTNPTQYL2100
 2101 EQHMMWDDIA ILGRYLLMLS FNNCLDVATS VPYLFHTITF LVCSGSLSMR ASTHGLVINI2160
 2161 IHSLCTCTNP SFSEEAQRVL RLSLDEFSLP KFYLLFGISK VKSAAVTAFR SSCRHPTDKW2220
 2221 LGNERVTQPL PADRERLSLP SLEVITDALL EIMEACMRDV PDCEWLNTWT SLARSFAFCY2280
 2281 NPALQPRALI VYGCISKSVT DHEVKQLLRI LVKALESFND LILIEALVMC LTRIQPLLRP2340
 2341 ESPIHRALFW VAISVLQLDE ITLYGAGLAL LEQNLHTLKS QGCFDKKETI AEVMMKTREK2400
 2401 LEWHFKQLDH AVGLSFRSNF HFALVGHLIK GFRHPTPTTV SRTSRVLTML LGIIAKPLHR2460
 2461 DKFEVTPDSV AYLTALVAVS EEVRSRCHVK HALPRWPADL SSSVENGEAS GGVQAIGLPL2520
 2521 SRRQKSWDIL DQSALQFARQ HKVPTLQERG SRSSVSNESN VLLDPEVLPD LSIQALVLTV2580
 2581 LATLVKYSSD EGETRVLYQY LAEGSVVFPK VFPVIHSLLD QKINNILSVS HDQVVLNSVQ2640
 2641 NIIQNMLASE DPSQQQLHFL QSCGFGGLWR FAGPFTKYNM MGESSELFVN CLEAMVETCL2700
 2701 PGDESAPVPP SPRPYNLSSS LSSLTLGSPT DKECPEAMTT ECERRK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Protein Overview: Nf1-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: