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Protein Overview: Nmnat-PA

General Information:
Name(s) found: Nmnat-PA / FBpp0084124 [FlyBase]
Description(s) found:
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  • gi|45550828|ref|NP_651315.2| nicotinamide mononucleotide adenylytransferase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|45446653|gb|AAF56373.4| nicotinamide mononucleotide adenylytransferase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|157816276|gb|ABV82132.1| AT03272p [Drosophila melanogaster] [NCBI NR]
  • The gene Nicotinamide mononucleotide adenylytransferase is referred to in FlyBase by the symbol Dmel\Nmnat (CG13645, FBgn0039254). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20770959..20773122. It has the cytological map location 96B11. There is experimental evidence that it has the molecular function</span>: nicotinamide-nucleotide adenylyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: photoreceptor cell maintenance. 13 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • (AAF56373) CG13645-PA [DrosMelano7227.FASTAC.txt]
  • CG13645-PA, isoform A [Drosophila melanogaster]gi|45550828|ref|NP_651315.2| CG13645-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(20770980..20771175,20771248..20771654,20771706..20771807,20771866..20772017,20772606..20772876,20772985..20773026); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,F [fly-100309-contam.fasta]
  • CG13645-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Nicotinamide mononucleotide adenylytransferase CG13645-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(20770980..20771175,20771248..20771654,20771706..20771807,20771866..20772017,20772606..20772876,20772985..20773026); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(20770980..20771175,20771248..20771654,20771706..20771807,20771866..20772017,20772606..20772876,20772985..20773026); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • AT03272p OS=Drosophila melanogaster GN=Nmnat PE=1 SV=4 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(20770980..20771175,20771248..20771654,20771706..20771807,20771866..20772017,20772606..20772876,20772985..20773026); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373,FlyMine:FBpp0084124,modMine:FBpp0084124; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • AT03272p OS=Drosophila melanogaster GN=Nmnat PE=2 SV=4 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:join(24945258..24945453,24945526..24945932,24945984..24946085,24946144..24946295,24946884..24947154,24947263..24947304); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373,FlyMine:FBpp0084124,modMine:FBpp0084124; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(24945258..24945453,24945526..24945932,24945984..24946085,24946144..24946295,24946884..24947154,24947263..24947304); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373,FlyMine:FBpp0084124,modMine:FBpp0084124; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Nicotinamide-nucleotide adenylyltransferase OS=Drosophila melanogaster GN=Nmnat PE=1 SV=4 [DROME.fasta.20160308]
  • FBpp0084124 type=protein; loc=3R:join(24945258..24945453,24945526..24945932,24945984..24946085,24946144..24946295,24946884..24947154,24947263..24947304); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373,FlyMine:FBpp0084124,modMine:FBpp0084124; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(24945258..24945453,24945526..24945932,24945984..24946085,24946144..24946295,24946884..24947154,24947263..24947304); ID=FBpp0084124; name=Nmnat-PA; parent=FBgn0039254,FBtr0084749; dbxref=GB_protein:AAF56373.3,FlyBase:FBpp0084124,FlyBase_Annotation_IDs:CG13645-PA,GB_protein:AAF56373.4,REFSEQ:NP_651315,GB_protein:AAF56373,UniProt/TrEMBL:Q9VC03,FlyMine:FBpp0084124,modMine:FBpp0084124; MD5=ed89573cf6e92d55ad8ec89e5a646e3c; length=389; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: photoreceptor cell maintenance [IMP]
    NAD biosynthetic process [IEA]
    Molecular Function: nicotinamide-nucleotide adenylyltransferase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVKISWPKN NITSECFRRF GSFKRRSKSK KMSAFIEETK SLLPRIAFIA CGCFSPPTPM  60
   61 HLRMFEIAKD HFEMQGTHRV VGGIISPTHD SYGKKGLASA LDRCAMVKLA TQSSNWIRLS 120
  121 DWEVHQNQWM RTQAVLQHHQ NYINNHINSG GGGGDDGENT HLPGWLPRGL HDSRDPVHLK 180
  181 LLCGADLLES FAVPGLWAEA DIEDIVANHG LVVITRAGSN PGKFIFDSDI LTKYQSNITL 240
  241 ITNWVPNEVS STLIRRLLGR GQSVKYLLDD LVLEYIKRQR LFNFKSKYIT DAVRPNHLLF 300
  301 NHAYTDNNKN ANSYSIGDQL EQDMDESDTP SPQLQHTPTS RVFCCGEVPL RGSKVLRSGP 360
  361 GQAVQVITMQ ADEKEESQAK KQKISQVQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..389] PSI-BLAST 71.221849 Nicotinamide mononucleotide (NMN) adenylyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nicotinate-nucleotide adenylyltransferase activity
    		•  2.94996967804011 bayes_pls_golite062009
  • nicotinamide-nucleotide adenylyltransferase activity
    		•  2.8149071156304 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  2.54008423253828 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  2.54008423253828 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  2.52910114154477 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • ligase activity
    		•  1.92894388839884 bayes_pls_golite062009
  • binding
    		•  1.11291710031577 bayes_pls_golite062009
  • adenylyltransferase activity
    		•  1.08055019963499 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.623161608923414 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.564359271862248 bayes_pls_golite062009
  • pantetheine-phosphate adenylyltransferase activity
    		•  0.454904507512502 bayes_pls_golite062009
  • pantoate-beta-alanine ligase activity
    		•  0.282286652169846 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle