Protein Overview: vari-PC, FBpp0307469

General Information:
Name(s) found:	FBpp0307469 [FlyBase] vari-PC / FBpp0088885 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|45551002\|ref\|NP_724289.2\| varicose, isoform C [Drosophila melanogaster] [NCBI NR] ref\|NP_724288.2\| CG9326-PB [Drosophila melanogaster] [NCBI NR] gi\|45445178\|gb\|AAN11090.2\| varicose, isoform C [Drosophila melanogaster] [NCBI NR] gb\|AAN11089.2\| CG9326-PB, isoform B [Drosophila melanogaster] [NCBI NR] type=protein; loc=2L:complement(20789247..20789423,20789586..20789660,20789721..20790052,20790125..20790335,20790391..20790552,20790622..20790720,20791167..20791520); ID=FBpp0307469; name=vari-PF; parent=FBgn0250785,FBtr0335501; dbxref=REFSEQ:NP_001260645,GB_protein:AGB93180,FlyBase:FBpp0307469,FlyBase_Annotation_IDs:CG9326-PF; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r5.56; species=Dmel; [FlyBase] The gene varicose is referred to in FlyBase by the symbol Dmel\vari (CG9326, FBgn0250785). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:20788659..20797040. It has the cytological map location 39D3-40B1. Based on sequence similarity, it is predicted to have molecular function</span>: guanylate kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal trunk growth, open tracheal system; regulation of tube size, open tracheal system; open tracheal system development; regulation of tube length, open tracheal system; septate junction assembly. 29 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; embryonic/larval tracheal system; portion of tissue; tracheal system; trachea; embryonic dorsal trunk; larval dorsal trunk; wing hair; embryonic tracheal system; embryonic ganglionic branch; external compound sense organ; plasma membrane part. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] (AAN11089) CG9326-PB [DrosMelano7227.FASTAC.txt] CG9326-PC, isoform C [Drosophila melanogaster]gi\|45445177\|gb\|AAN11089.2\| CG9326-PB, isoform B [Drosophila melanogaster]gi\|45551002\|ref\|NP_724289.2\| CG9326-PC [Drosophila melanogaster]gi\|45551000\|ref\|NP_724288.2\| CG9326-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(20789247..20789423,20789586..20789660,20789721..20790052,20790125..20790335,20790391..20790552,20790622..20790720,20791167..20791520); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_ [fly-100309-contam.fasta] CG9326-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(20789247..20789423,20789586..20789660,20789721..20790052,20790125..20790335,20790391..20790552,20790622..20790720,20791167..20791520); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(20789247..20789423,20789586..20789660,20789721..20790052,20790125..20790335,20790391..20790552,20790622..20790720,20791167..20791520); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Varicose, isoform C OS=Drosophila melanogaster GN=vari PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:complement(20789247..20789423,20789586..20789660,20789721..20790052,20790125..20790335,20790391..20790552,20790622..20790720,20791167..20791520); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090,FlyMine:FBpp0088885,modMine:FBpp0088885; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090,FlyMine:FBpp0088885,modMine:FBpp0088885; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0307469; name=vari-PF; parent=FBgn0250785,FBtr0335501; dbxref=REFSEQ:NP_001260645,GB_protein:AGB93180,FlyBase:FBpp0307469,FlyBase_Annotation_IDs:CG9326-PF; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090,FlyMine:FBpp0088885,modMine:FBpp0088885; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0307469; name=vari-PF; parent=FBgn0250785,FBtr0335501; dbxref=REFSEQ:NP_001260645,GB_protein:AGB93180,FlyBase:FBpp0307469,FlyBase_Annotation_IDs:CG9326-PF; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of Q7KT16, Varicose, isoform C OS=Drosophila melanogaster GN=vari PE=1 SV=1 [DROME.fasta.20160308] FBpp0088885 type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090,FlyMine:FBpp0088885,modMine:FBpp0088885; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0307469 type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0307469; name=vari-PF; parent=FBgn0250785,FBtr0335501; dbxref=REFSEQ:NP_001260645,GB_protein:AGB93180,FlyBase:FBpp0307469,FlyBase_Annotation_IDs:CG9326-PF; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0088885; name=vari-PC; parent=FBgn0250785,FBtr0089946; dbxref=FlyBase_Annotation_IDs:CG9326-PC,FlyBase:FBpp0088885,GB_protein:AAN11090.2,REFSEQ:NP_724289,GB_protein:AAN11090,UniProt/TrEMBL:Q2PDR9,FlyMine:FBpp0088885,modMine:FBpp0088885; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(join(20791167..20791520,20790622..20790720,20790391..20790552,20790125..20790335,20789721..20790052,20789586..20789660,20789247..20789423)); ID=FBpp0307469; name=vari-PF; parent=FBgn0250785,FBtr0335501; dbxref=REFSEQ:NP_001260645,GB_protein:AGB93180,FlyBase:FBpp0307469,FlyBase_Annotation_IDs:CG9326-PF,UniProt/TrEMBL:Q2PDR9; MD5=78b3bd3d6c78b249fcacf1df13dba7b2; length=469; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	469 amino acids
Gene Ontology:
Cellular Component:	lateral plasma membrane [IDA] membrane [ISS] septate junction [IDA]
Biological Process:	dorsal trunk growth, open tracheal system [IMP] regulation of tube size, open tracheal system [IMP] septate junction assembly [IMP] regulation of tube length, open tracheal system [IMP] open tracheal system development [IMP]
Molecular Function:	protein binding [IEA] guanylate kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVETIKMVG LRRDPSKPLG LTVELDEFKQ LVVARILAGG VIDKQSMLHV GDVILEVNGT  60
   61 PVRTPDELQV EVSRAKENLT LKIGPNVDEE IKSGRYTVSG GQVKQNGIAS LETGKKLTCY 120
  121 MRALFTYNPS EDSLLPCRDI GLPFKSGDIL QIINVKDPNW WQAKNITAES DKIGLIPSQE 180
  181 LEERRKAFVA PEADYVHKIG ICGTRISKRK RKTMYRSVAN CEFDKAELLL YEEVTRMPPF 240
  241 RRKTLVLIGV SGVGRRTLKN RLINSDVDKF GAVIPHTSRP KRALEENGSS YWFMDREEME 300
  301 EAVRNNEFLE YGEHNGNLYG THLQSIKDVI NSGRMCILDC APNALKILHN SQELMPFVIF 360
  361 VAAPGMEQLK TIYADRRATG SNRNLSFDRQ SSIRFSSRRA RTLESLASLY EDDDLVATVE 420
  421 ESSFVQRKYE KYFDMVIVNE DFDETFRQVV ETLDQMSHEE QWVPVNWIY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: vari-PC, FBpp0307469

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: