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Protein Overview: Graf-PE, Graf-PD...

General Information:
Name(s) found: FBpp0311354 [FlyBase]
Graf-PE / FBpp0089213 [FlyBase]
Graf-PD / FBpp0089212 [FlyBase]
Graf-PA / FBpp0073979 [FlyBase]
Description(s) found:
Found 67 descriptions.
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  • type=protein; loc=X:complement(15646266..15646366,15646426..15646505,15646574..15647869,15647942..15648047,15648118..15648448,15648519..15648805,15649137..15649188,15649248..15649319,15649380..15649595,15649852..15650025,15650112..15650269,15651889..15652066); ID=FBpp0311354; name=Graf-PJ; parent=FBgn0030685,FBtr0345133; dbxref=FlyBase:FBpp0311354,FlyBase_Annotation_IDs:CG8948-PJ; MD5=9dd0a1d205e825755b11271d7b7da6f5; length=1016; release=r5.56; species=Dmel; [FlyBase]
  • The gene Graf is referred to in FlyBase by the symbol Dmel\Graf (CG8948, FBgn0030685). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15645707..15654741. It has the cytological map location 13E14. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: signal transduction. 11 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Graf is referred to in FlyBase by the symbol Dmel\Graf (CG8948, FBgn0030685). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15645707..15654741. It has the cytological map location 13E14. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: signal transduction. 11 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Graf is referred to in FlyBase by the symbol Dmel\Graf (CG8948, FBgn0030685). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15645707..15654741. It has the cytological map location 13E14. Based on sequence similarity, it is predicted to have molecular function</span>: Rho GTPase activator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: signal transduction. 11 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1016 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: signal transduction [IEA]
    Molecular Function: Rho GTPase activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGGKNVRRG LEPLEFEECI VDSPDFRENL NRHEKELDHT SHQIKRIIKE VKDLMSAAKI  60
   61 LSTRMKQLAI LLNDFNFECI GTAQTDDENV ICESLKRFGA IIGNIEDERE KMLTLADKHI 120
  121 IESLEDFRKK QIGGVKENKK KFDKKTEKFC QSQERFLNMS TKKPENTIQE ADASLGMHER 180
  181 EYIQESLSYV LRIQEVQERI KFEFVEILLA FISGWLVFYH TAHEQAEDHR DYLQDLRHKV 240
  241 QKTRENFEEA REKVTELKTK YMEKRTKPEE IFTKRGYLFL MEKKPFKATW TKYYCTFKKQ 300
  301 KREFTMLQFN QMNHNFTRPE ARDDEKLTLF SCQRRASEFE KRFCFDLTFK EKPGVVYTFQ 360
  361 ALSEKDHRYW ISAMDGTEPT YLAPGKIKVS EAYHLDEAGF MFIRRCIQVL EIRGLEDEGI 420
  421 YRKSGVGTKI SKLLALGLNQ KESDDVFVDD KYRDLMESNT IASALKMYLR NLNEPLMTYQ 480
  481 YHSDFIEAAK QETLNQRVNE VHKLVYKLPQ PNFQMLDMVI CHLTDVSRKY EKNKMSVFNL 540
  541 GVVFGPTLLR PREESVAAIL DIKFNNIVIN ILIDNYERIF KNKPSADIKL PDATKAPSIM 600
  601 YPSRSSPPTR MPRASQIGKA ASTGAMGSSS NTAGNPMFLN QQKIYRVVSK TNCTEPTMSS 660
  661 SLQNIPNGDN YALGSNAMNS SGGAQCISLS PPMHMLNGIL SPTIGSINNL HTISKNETST 720
  721 RRYVPDTEIA PDYGIIGANN GGVTLQSHHA VPVSSTSNFR HPEYLMTTAN PVTQSGSSSH 780
  781 IYTNTSSAGA NSSNRISLSN VSPPNTAMRK ERFLGSASGP QQHPPVQRGL HSYGQTKHYS 840
  841 PLMPTSTSSS NDSVCDSLSS NNGLGSSIVA NSGNSGNVAQ HLSARNTNDY ALISSQNSSL 900
  901 SPHLGPTCDE VVTATTLPSV SLSCGGTASE STEYPPSKMH RNRDVNQIKR DLSTGTARVR 960
  961 TLYACMGESE GELSFEPNQI ITNVRYSHEP GWLQGTLNGK TGLIPENYVE HLKPHH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 31.39794 No description for 2elbA was found.
    2 View Details [187..375] FFAS03 3.02 No description for 2elbA was found.
    3 View Details [376..582] PSI-BLAST 25.69897 Graf
    4 View Details [583..845] deduced N/A No confident structure predictions are available.
    5 View Details [846..1016] PSI-BLAST 11.522879 53BP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.171962044848065 bayes_pls_golite062009
  • protein binding
    		•  0.04256104607293 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.46923761062082 bayes_pls_golite062009
  • protein binding
    		•  0.127111860178639 bayes_pls_golite062009
    3
    Term Confidence Notes
  • enzyme regulator activity
    		•  0.68732227880003 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.590837939249671 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.59070509814251 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.53004209819211 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.528693496432149 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.10243777232979 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0454578418356197 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle