Protein Overview: Sk2-PA

General Information:
Name(s) found:	Sk2-PA / FBpp0072854 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|45550531\|ref\|NP_647762.3\| sphingosine kinase 2 [Drosophila melanogaster] [NCBI NR] gi\|45445771\|gb\|AAF47706.3\| sphingosine kinase 2 [Drosophila melanogaster] [NCBI NR] gi\|17862170\|gb\|AAL39562.1\| LD11247p [Drosophila melanogaster] [NCBI NR] The gene Sphingosine kinase 2 is referred to in FlyBase by the symbol Dmel\Sk2 (CG32484, FBgn0052484). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:3046956..3050161. It has the cytological map location 63A3-63A4. There is experimental evidence that it has the molecular function</span>: D-erythro-sphingosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: sphingolipid metabolic process; oviposition; flight behavior; phosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] (AAF47706) CG32484-PA [DrosMelano7227.FASTAC.txt] CG32484-PA [Drosophila melanogaster]gi\|17862170\|gb\|AAL39562.1\| LD11247p [Drosophila melanogaster]gi\|45550531\|ref\|NP_647762.3\| CG32484-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706; MD5=28e3828 [fly-100309-contam.fasta] Sphingosine kinase 2 CG32484-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG32484-PA [Drosophila melanogaster] [nr-271106-contam.fasta] LD11247p [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] LD11247p OS=Drosophila melanogaster GN=Sk2 PE=2 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706,FlyMine:FBpp0072854,modMine:FBpp0072854; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706,FlyMine:FBpp0072854,modMine:FBpp0072854; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706,FlyMine:FBpp0072854,modMine:FBpp0072854; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] LD11247p OS=Drosophila melanogaster GN=Sk2 PE=1 SV=3 [DROME.fasta.20160308] FBpp0072854 type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706,FlyMine:FBpp0072854,modMine:FBpp0072854; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(3047190..3048166,3048646..3049654); ID=FBpp0072854; name=Sk2-PA; parent=FBgn0052484,FBtr0072984; dbxref=FlyBase_Annotation_IDs:CG32484-PA,FlyBase:FBpp0072854,GB_protein:AAF47706.3,REFSEQ:NP_647762,GB_protein:AAF47706,UniProt/TrEMBL:Q9VZW0,FlyMine:FBpp0072854,modMine:FBpp0072854; MD5=28e38284382e0928a36253fa884181dc; length=661; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	661 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	flight behavior [IMP] oviposition [IMP] phosphorylation [IDA][NAS] activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEA] sphingolipid metabolic process [IDA]
Molecular Function:	D-erythro-sphingosine kinase activity [IDA][ISS][TAS] diacylglycerol kinase activity [IEA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESLDKTTS PSSASSRATP PGTQDADEGH DVSDTFYTSQ RKKGSHVFRV RLDATGFTLQ  60
   61 RESPGGSIVK EQHVRISDIV GARCMRPKKS RRLAMSGACA CSSGNPNSPA ISASGDHHRP 120
  121 ATTPSKCSTN SRDNIPSDGG DVSAFLYVFA YVLKKRSLRS ELHRERTVLT LRFRSFDTFE 180
  181 DNMREADRWY RSLRWQLHRT LEEIFVAPTV DERRRRVLVL LNPKSGSGDA REVFNMHVTP 240
  241 VLNEAEVPYD LYVTKHSNFA IEFLSTRCLD AWCCVVAVGG DGLFHEIVNG LLQRQDWAHV 300
  301 LPHLALGIIP CGSGNGLARS IAHCYNEPYF SKPVLGAALT VISGRSSPMD VVRVQLQSRS 360
  361 LYSFLSIGWG LISDVDIESE RIRMLGYQRF TVWTLYRLVN LRTYNGRISY LLTDHEVSST 420
  421 HSATGYAAQR RMQSSRSCNT HIDMLNGPAP IYHSSAEYLP QEFADVISLE TSINQSFRSR 480
  481 CDSWLSGGSR RSFYYSISES IYHSLADESE FAGLAAASLE NRQQNYGPAS ELPDLNEPLS 540
  541 EDQGWLVEEG EFVMMHAVYQ THLGIDCHFA PKAQLNDGTI YLILIRAGIS RPHLLSFLYN 600
  601 MSSGTHLPES HDDHVKVLPV RAFRLEPYDN HGIITVDGER VEFGPLQAEV LPGIARVMVP 660
  661 K

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Protein Overview: Sk2-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: