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Protein Overview: Crag-PB

General Information:
Name(s) found: Crag-PB / FBpp0089320 [FlyBase]
Description(s) found:
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  • gi|45551437|ref|NP_727281.2| Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45446868|gb|AAF46397.3| Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|157816793|gb|ABV82388.1| LP24278p [Drosophila melanogaster] [NCBI NR]
  • The gene Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein is referred to in FlyBase by the symbol Dmel\Crag (CG12737, FBgn0025864). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8486086..8495264. It has the cytological map location 7F7-7F8. There is experimental evidence that it has the molecular function</span>: calmodulin binding. There is experimental evidence that it is involved in the biological process</span>: asymmetric protein localization; basement membrane assembly. 12 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • (AAF46397) CG12737-PB [DrosMelano7227.FASTAC.txt]
  • CG12737-PB, isoform B [Drosophila melanogaster]gi|45551437|ref|NP_727281.2| CG12737-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0290510; name=Cra [fly-100309-contam.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0089320; name=Cra [fly-100309-contam.fasta]
  • Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein CG12737-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG12737-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0290510; name=Crag-PC; parent=FBgn0025864,FBtr0301295; dbxref=FlyBase:FBpp0290510,FlyBase_Annotation_IDs:CG12737-PC; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0290510; name=Crag-PC; parent=FBgn0025864,FBtr0301295; dbxref=FlyBase:FBpp0290510,FlyBase_Annotation_IDs:CG12737-PC; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform B OS=Drosophila melanogaster GN=Crag PE=2 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0290510; name=Crag-PC; parent=FBgn0025864,FBtr0301295; dbxref=REFSEQ:NP_001162710,GB_protein:ACZ95245,FlyBase:FBpp0290510,FlyBase_Annotation_IDs:CG12737-PC; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(8487529..8487829,8488126..8488672,8488731..8488881,8488944..8489215,8489281..8489494,8489571..8489891,8489961..8491387,8491445..8491747,8493064..8493496,8493561..8494022,8494095..8494279,8494343..8494661); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397,FlyMine:FBpp0089320,modMine:FBpp0089320; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(8593496..8593796,8594093..8594639,8594698..8594848,8594911..8595182,8595248..8595461,8595538..8595858,8595928..8597354,8597412..8597714,8599031..8599463,8599528..8599989,8600062..8600246,8600310..8600628); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397,FlyMine:FBpp0089320,modMine:FBpp0089320; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(8593496..8593796,8594093..8594639,8594698..8594848,8594911..8595182,8595248..8595461,8595538..8595858,8595928..8597354,8597412..8597714,8599031..8599463,8599528..8599989,8600062..8600246,8600310..8600628); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397,FlyMine:FBpp0089320,modMine:FBpp0089320; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W3D3, Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform B OS=Drosophila melanogaster GN=Crag PE=1 SV=3 [DROME.fasta.20160308]
  • FBpp0089320 type=protein; loc=X:join(8593496..8593796,8594093..8594639,8594698..8594848,8594911..8595182,8595248..8595461,8595538..8595858,8595928..8597354,8597412..8597714,8599031..8599463,8599528..8599989,8600062..8600246,8600310..8600628); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397,FlyMine:FBpp0089320,modMine:FBpp0089320; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(8593496..8593796,8594093..8594639,8594698..8594848,8594911..8595182,8595248..8595461,8595538..8595858,8595928..8597354,8597412..8597714,8599031..8599463,8599528..8599989,8600062..8600246,8600310..8600628); ID=FBpp0089320; name=Crag-PB; parent=FBgn0025864,FBtr0071220; dbxref=GB_protein:AAF46397.2,GB_protein:AAF46397.3,FlyBase:FBpp0089320,FlyBase_Annotation_IDs:CG12737-PB,REFSEQ:NP_727281,GB_protein:AAF46397,UniProt/TrEMBL:Q9W3D2,FlyMine:FBpp0089320,modMine:FBpp0089320; MD5=4953fad0f30dfb3618234857c178f2cf; length=1644; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1644 amino acids

    Gene Ontology:
    Cellular Component: cell cortex [IDA]
    recycling endosome [IDA]
    Biological Process: basement membrane assembly [IMP]
    asymmetric protein localization [IMP]
    Molecular Function: calmodulin binding [IDA]
    guanyl-nucleotide exchange factor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEKRIADYF VVAGMPENPQ LLQENSFNDS GRLRAATTIE PITDIGVYFP LLGEEVPEGY  60
   61 EILSHTPTGL QANLNHGSVR TTDCYIYFRR GKDRPPLVDI GVLYDGHERI MSDAEIVAET 120
  121 PGGRVANVNN SSAKTFLTYR RARADMPCNE LVVTELCVIV QSKGERAPHA FCLIYKTLNK 180
  181 GYVGSDVYLC YKKSMYRPKH ISYKPEILLR YPTFDHTDFP LNLCPSVPLF CLPMGASLEA 240
  241 WPHVNGTEKR KPISPVFSTF VLTVSDGTYK VYGSALTFYE DYDESKLSAE QKELLGWDEE 300
  301 FGAQHSLHMI KAICLLSHHP FGDTFDKWLK YLHRMVLYDV NIPIPVERYI TQLLDEVPFP 360
  361 APSIHLQLSS ESNDRILLTQ PEDSPLPRSG AGFHILLQNL GTDNCLHVLL LALTEQKILI 420
  421 HSLRPATLTA VAEAIVSLLF PFKWQCPYIP LCPLGLAEVL HAPLPYLIGV DSRFFDLYEP 480
  481 PTDVTCIDLD TNNISLCESQ RHLSPKLLPK RAARLLRQTL TELENAKPIS YDSTNSLDRD 540
  541 IRKRKRELVL EQRIQEAFLL FMASILRGYR DFLVPISKAP SVGATDPSAL FQLKAFLRSR 600
  601 DKSHQKFFEL MMKTQMFIRF IEERSFVSDG DHGLSFFDEC AEKVGNYDET PAQLHLVDWD 660
  661 TGQNSERTKY IFPPDSVTPA GSQPGGGGGG LAYNYENFTL QPELLQSTKK TALSKFLQLQ 720
  721 LNASLSPGSP IARRTKHEIK LSQKMASRCQ QHPEAWSKYL LATCYSLYFL ILPSMVLDPR 780
  781 HAGKEPEILR AAYDVLVRAS RLKITCDEFC YRIMMQLCGI HNLPVLAVRL HYLMKRSGVQ 840
  841 ANALTYGFYN RCVLESQWPQ DSTTISQIRW NRIKNVVLGA AQFRKAGKQR AASKVNKSLS 900
  901 ASQDQNLSTL ETVDGQSRTS LASSSGDGGG HGLLDFAAFD RLRNKLGSIV RQTVTGGNNE 960
  961 TMGDAVNNTG LLIPGELSAP NTPTYGGDTE ILAKALQQQQ PRKQIMSIGG GDDDDEDEDE1020
 1021 DEYTAGSPST PQKQLEAGAD DLEYAGGGDY EADEEDEDEV DEHVAAQRAR QRVQSPTKIS1080
 1081 PRTPVTQNDP LGALNEEESA ASATPTQETQ QEQQHSQSQI DSSIYSDKPI LFRGQRSATF1140
 1141 DESTQIGKSM HRSETMPVAS SGVTNSLANI GSSLKFTFGP SLTGKKSNEL IQGSLSSIKS1200
 1201 AANSLTKKFD EIKGVISANS TPTKTNNGHH PHGLHHGHHH PHHHHHHHSQ HGNAEQEEHD1260
 1261 AAVHEEGKLR RVSSDLDPWG RLSESRKSSY NNLVPLGENS STGALHMHAF PAVPDNLYSL1320
 1321 TSENAADRDC DVLIQLTTCS QCHNCSVLVY DEEIMSGWTA EDSNLNTTCH ACNKLTVPFL1380
 1381 SVQIERQVEE SEQSDPLQDG KEQIANGNSH KTSLTVPYLN PLVLRKELEN ILTQEGDIAL1440
 1441 IKPEFVDEHP IIYWNLLWLM ERIESKTHLP ELCLPVPSDK EHIDPLSKVK TVHIQCLWDN1500
 1501 LSLHTEASGP PMYLLYRETQ PTSPLIKALL TDQAQLNKNV IQQIISAIRC NDFATPLKRL1560
 1561 ANERHKLKSN GVERSHSFYR DILFLALTAI GRSNVDLATF HREYAAVFDK LTERECNMYY1620
 1621 RNQDLPPSAS TIFCRAYFRP LLLP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] deduced N/A No confident structure predictions are available.
    2 View Details [186..283] Pfam 3.107905 No description for PF03456.9 was found. No confident structure predictions are available.
    3 View Details [284..546] Pfam 66.886057 No description for PF02141.12 was found. No confident structure predictions are available.
    4 View Details [547..626] Pfam 34.200659 No description for PF03455.10 was found. No confident structure predictions are available.
    5 View Details [627..694] deduced N/A No confident structure predictions are available.
    6 View Details [695..888] MSA 20.105987 View MSA. No confident structure predictions are available.
    7 View Details [889..950] deduced N/A No confident structure predictions are available.
    8 View Details [951..1152] deduced N/A No confident structure predictions are available.
    9 View Details [1153..1326] MSA 4.254988 View MSA. No confident structure predictions are available.
    10 View Details [1327..1417] deduced N/A No confident structure predictions are available.
    11 View Details [1418..1644] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle