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Protein Overview: PAICS

General Information:
Name(s) found: PAICS [HGNC (HUGO)]
Description(s) found:
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  • gi|5453539|ref|NP_006443.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 2 [Homo sapiens] [NCBI NR]
  • gi|30582815|gb|AAP35634.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI NR]
  • gi|28384|emb|CAA37801.1| ADE2H1 [Homo sapiens] [NCBI NR]
  • gi|17939425|gb|AAH19255.1| Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI NR]
  • gi|16307450|gb|AAH10273.1| Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI NR]
  • gi|131628|sp|P22234.3|PUR6_HUMAN RecName: Full=Multifunctional protein ADE2; Includes: RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; AltName: Full=SAICAR synthetase; Includes: RecName: Full=Phosphoribosylaminoimidazole carboxylas [NCBI NR]
  • gi|119625897|gb|EAX05492.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119625896|gb|EAX05491.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119220557|ref|NP_001072992.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 2 [Homo sapiens] [NCBI NR]
  • pir||S14147 multifunctional purine biosynthesis protein - human [NCBI NR]
  • phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [HGNC (HUGO)]
  • Multifunctional protein ADE2 OS=Homo sapiens GN=PAICS PE=1 SV=3 [Swiss-Prot]
  • phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; AIR carboxylase; SAICAR synthetase [HMR_022704.fasta]
  • phosphoribosylaminoimidazole carboxylase; AIR carboxylase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase [Human2242005.fasta]
  • PAICS protein [Homo sapiens]gi|5453539|ref|NP_006443.1| phosphoribosylaminoimidazole carboxylase [Homo sapiens]gi|30582815|gb|AAP35634.1| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (AIR carboxylase) (AIRC)] [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_006452) phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • phosphoribosylaminoimidazole carboxylase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • phosphoribosylaminoimidazole carboxylase; AIR carboxylase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [HumanGallus06162005.fasta]
  • phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; AIR carboxylase; SAICAR synthetase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ADE2H1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • PAICS protein [Homo sapiens] [nr-271106-contam.fasta]
  • [human_BMb_040710_contam.fasta]
  • P22234; RecName: Full=Multifunctional protein ADE2; Includes: RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase; AltName: Full=SAICAR synthetase; Includes: RecName: Full=Phosphoribosylaminoimidazole carboxylase; AltName: Full=AIR carboxylase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Multifunctional protein ADE2 OS=Homo sapiens GN=PAICS [011711_HMR.fasta]
  • GeneSymbol=PAICS Synonyms=ADE2|ADE2H1|AIRC|DKFZp781N1372|MGC1343|MGC5024|PAIS multifunctional protein ADE2 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Isoform 1 of Multifunctional protein ADE2 OS=Homo sapiens GN=PAICS [122011_hum.fasta]
  • Multifunctional protein ADE2 GN=PAICS [Doctor+uniprot-HUMAN-120911.fasta]
  • Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c OS=Homo sapiens GN=PAICS PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATAEVLNIG KKLYEGKTKE VYELLDSPGK VLLQSKDQIT AGNAARKNHL EGKAAISNKI  60
   61 TSCIFQLLQE AGIKTAFTRK CGETAFIAPQ CEMIPIEWVC RRIATGSFLK RNPGVKEGYK 120
  121 FYPPKVELFF KDDANNDPQW SEEQLIAAKF CFAGLLIGQT EVDIMSHATQ AIFEILEKSW 180
  181 LPQNCTLVDM KIEFGVDVTT KEIVLADVID NDSWRLWPSG DRSQQKDKQS YRDLKEVTPE 240
  241 GLQMVKKNFE WVAERVELLL KSESQCRVVV LMGSTSDLGH CEKIKKACGN FGIPCELRVT 300
  301 SAHKGPDETL RIKAEYEGDG IPTVFVAVAG RSNGLGPVMS GNTAYPVISC PPLTPDWGVQ 360
  361 DVWSSLRLPS GLGCSTVLSP EGSAQFAAQI FGLSNHLVWS KLRASILNTW ISLKQADKKI 420
  421 RECNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle