Protein Overview: MACF1

General Information:
Name(s) found:	MACF1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|56405387\|sp\|Q9UPN3.3\|MACF1_HUMAN RecName: Full=Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; AltName: Full=Actin cross-linking family protein 7; AltName: Full=Macrophin-1; AltName: Full=Trabeculin-alpha; AltName: Full=620 kDa actin-bindin [NCBI NR] gi\|56204529\|emb\|CAI21814.1\| microtubule-actin crosslinking factor 1 [Homo sapiens] [NCBI NR] gi\|55959644\|emb\|CAI16417.1\| microtubule-actin crosslinking factor 1 [Homo sapiens] [NCBI NR] gi\|55665462\|emb\|CAH73668.1\| microtubule-actin crosslinking factor 1 [Homo sapiens] [NCBI NR] gi\|55662923\|emb\|CAH70156.1\| microtubule-actin crosslinking factor 1 [Homo sapiens] [NCBI NR] gi\|33188445\|ref\|NP_036222.3\| microfilament and actin filament cross-linker protein isoform a [Homo sapiens] [NCBI NR] microtubule-actin crosslinking factor 1 [HGNC (HUGO)] Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 PE=1 SV=3 [Swiss-Prot] microfilament and actin filament cross-linker protein isoform a; 620 kDa actin binding protein; actin cross-linking factor; macrophin 1; trabeculin-alpha; actin cross-linking family protein 7 [HMR_022704.fasta] microfilament and actin filament cross-linker protein isoform a [Homo sapiens]gi\|55665462\|emb\|CAH73668.1\| OTTHUMP00000046304 [Homo sapiens]gi\|55662923\|emb\|CAH70156.1\| microtubule-actin crosslinking factor 1 [Homo sapiens] [nrdb_11152004_Chlamydomonas] microfilament and actin filament cross-linker protein isoform a; actin cross-linking factor; 620 kDa actin binding protein; macrophin 1; trabeculin-alpha; actin cross-linking family protein 7 [Human2242005.fasta] Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin 1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 2 of Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] microfilament and actin filament cross-linker protein isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] microfilament and actin filament cross-linker protein isoform a; actin cross-linking factor; 620 kDa actin binding protein; macrophin 1; trabeculin-alpha; actin cross-linking family protein 7 [Homo sapiens] [HumanGallus06162005.fasta] microfilament and actin filament cross-linker protein isoform a; 620 kDa actin binding protein; actin cross-linking factor; macrophin 1; trabeculin-alpha; actin cross-linking family protein 7 [Homo sapiens] [human-NCBI-042104-rand.fasta] Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] microtubule-actin crosslinking factor 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=MACF1 Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 [human-ipi-250309-contam.fasta] IPI:IPI00256861.4\|SWISS-PROT:Q9UPN3-2\|TREMBL:Q13696\|ENSEMBL:ENSP00000354573\|REFSEQ:NP_036222\|VEGA:OTTHUMP00000009301 Tax_Id=9606 Gene_Symbol=MACF1 Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] microtubule-actin cross-linking factor 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Q9UPN3;O75053;Q5VW20;Q8WXY2;Q9H540;Q9UKP0;Q9ULG9; RecName: Full=Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; AltName: Full=Actin cross-linking family protein 7; AltName: Full=Macrophin-1; AltName: Full=Trabeculin-alpha; AltName: Full=620 kDa actin-binding protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 [011711_HMR.fasta] GeneSymbol=MACF1 Synonyms=ABP620\|ACF7\|FLJ45612\|FLJ46776\|KIAA0465\|KIAA1251\|MACF\|OFC4 microtubule-actin cross-linking factor 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00256861.4\|SWISS-PROT:Q9UPN3-2\|ENSEMBL:ENSP00000354573;ENSP00000439537\|REFSEQ:NP_036222\|VEGA:OTTHUMP00000009301 Tax_Id=9606 Gene_Symbol=MACF1 Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 [ipi.HUMAN.20110912.fasta] Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 GN=MACF1 [Doctor+uniprot-HUMAN-120911.fasta] Isoform of Q9UPN3, Isoform 2 of Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 [2016-04-human-contam-aPKC-His-Par6.fasta]
Organism:	Homo sapiens
Length:	5430 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS  60
   61 VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS 120
  121 GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ VKLVNIRNDD ITDGNPKLTL GLIWTIILHF 180
  181 QISDIYISGE SGDMSAKEKL LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL 240
  241 VDMERVQIQS NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 300
  301 PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK ALYNQYIHFK 360
  361 ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND VEEEWGKLII EMLEREKSLR 420
  421 PAVERLELLL QIANKIQNGA LNCEEKLTLA KNTLQADAAH LESGQPVQCE SDVIMYIQEC 480
  481 EGLIRQLQVD LQILRDENYY QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP 540
  541 STLTTTHLKA EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ 600
  601 MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF HTSYAETLGK 660
  661 LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE EEELAYDWSD NNSNISAKRN 720
  721 YFSELTMELE EKQDVFRSLQ DTAELLSLEN HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ 780
  781 HVKENTAYFQ FFSDARELES FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ 840
  841 SKSSVASLVG RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR 900
  901 TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL HVNTKSLISW 960
  961 NYLRKDLDLV QTWNLEKLRS SAPGECHQIM KNLQAHYEDF LQDSRDSVLF SVADRLRLEE1020
 1021 EVEACKARFQ HLMKSMENED KEETVAKMYI SELKNIRLRL EEYEQRVVKR IQSLASSRTD1080
 1081 RDAWQDNALR IAEQEHTQED LQQLRSDLDA VSMKCDSFLH QSPSSSSVPT LRSELNLLVE1140
 1141 KMDHVYGLST VYLNKLKTVD VIVRSIQDAE LLVKGYEIKL SQEEVVLADL SALEAHWSTL1200
 1201 RHWLSDVKDK NSVFSVLDEE IAKAKVVAEQ MSRLTPERNL DLERYQEKGS QLQERWHRVI1260
 1261 AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM MKPGQAEDSR VLSEQLSQQT1320
 1321 ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY ELQLMTYKAF VESQQKSPGK RRRMLSSSDA1380
 1381 ITQEFMDLRT RYTALVTLTT QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST1440
 1441 LARNTQGKAT SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS1500
 1501 EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKTLQKQQN TCHQQLEDLC1560
 1561 SWVGQAERAL AGHQGRTTQQ DLSALQKNQS DLKDLQDDIQ NRATSFATVV KDIEGFMEEN1620
 1621 QTKLSPRELT ALREKLHQAK EQYEALQEET RVAQKELEEA VTSALQQETE KSKAAKELAE1680
 1681 NKKKIDALLD WVTSVGSSGG QLLTNLPGME QLSGASLEKG ALDTTDGYMG VNQAPEKLDK1740
 1741 QCEMMKARHQ ELLSQQQNFI LATQSAQAFL DQHGHNLTPE EQQMLQQKLG ELKEQYSTSL1800
 1801 AQSEAELKQV QTLQDELQKF LQDHKEFESW LERSEKELEN MHKGGSSPET LPSLLKRQGS1860
 1861 FSEDVISHKG DLRFVTISGQ KVLDMENSFK EGKEPSEIGN LVKDKLKDAT ERYTALHSKC1920
 1921 TRLGSHLNML LGQYHQFQNS ADSLQAWMQA CEANVEKLLS DTVASDPGVL QEQLATTKQL1980
 1981 QEELAEHQVP VEKLQKVARD IMEIEGEPAP DHRHVQETTD SILSHFQSLS YSLAERSSLL2040
 2041 QKAIAQSQSV QESLESLLQS IGEVEQNLEG KQVSSLSSGV IQEALATNMK LKQDIARQKS2100
 2101 SLEATREMVT RFMETADSTT AAVLQGKLAE VSQRFEQLCL QQQEKESSLK KLLPQAEMFE2160
 2161 HLSGKLQQFM ENKSRMLASG NQPDQDITHF FQQIQELNLE MEDQQENLDT LEHLVTELSS2220
 2221 CGFALDLCQH QDRVQNLRKD FTELQKTVKE REKDASSCQE QLDEFRKLVR TFQKWLKETE2280
 2281 GSIPPTETSM SAKELEKQIE HLKSLLDDWA SKGTLVEEIN CKGTSLENLI MEITAPDSQG2340
 2341 KTGSILPSVG SSVGSVNGYH TCKDLTEIQC DMSDVNLKYE KLGGVLHERQ ESLQAILNRM2400
 2401 EEVHKEANSV LQWLESKEEV LKSMDAMSSP TKTETVKAQA ESNKAFLAEL EQNSPKIQKV2460
 2461 KEALAGLLVT YPNSQEAENW KKIQEELNSR WERATEVTVA RQRQLEESAS HLACFQAAES2520
 2521 QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK QQVQFMLKEF EARRQQHEQL NEAAQGILTG2580
 2581 PGDVSLSTSQ VQKELQSINQ KWVELTDKLN SRSSQIDQAI VKSTQYQELL QDLSEKVRAV2640
 2641 GQRLSVQSAI STQPEAVKQQ LEETSEIRSD LEQLDHEVKE AQTLCDELSV LIGEQYLKDE2700
 2701 LKKRLETVAL PLQGLEDLAA DRINRLQAAL ASTQQFQQMF DELRTWLDDK QSQQAKNCPI2760
 2761 SAKLERLQSQ LQENEEFQKS LNQHSGSYEV IVAEGESLLL SVPPGEEKRT LQNQLVELKN2820
 2821 HWEELSKKTA DRQSRLKDCM QKAQKYQWHV EDLVPWIEDC KAKMSELRVT LDPVQLESSL2880
 2881 LRSKAMLNEV EKRRSLLEIL NSAADILINS SEADEDGIRD EKAGINQNMD AVTEELQAKT2940
 2941 GSLEEMTQRL REFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL RAQQEVLQAL3000
 3001 EPQVDYLRNF TQGLVEDAPD GSDASQLLHQ AEVAQQEFLE VKQRVNSGCV MMENKLEGIG3060
 3061 QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDV RLFLNKIHVL KLDIEASEAE3120
 3121 CRHMLEEEGT LDLLGLKREL EALNKQCGKL TERGKARQEQ LELTLGRVED FYRKLKGLND3180
 3181 ATTAAEEAEA LQWVVGTEVE IINQQLADFK MFQKEQVDPL QMKLQQVNGL GQGLIQSAGK3240
 3241 DCDVQGLEHD MEEINARWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLADTEELI3300
 3301 ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQSAEL ADREKITGQL3360
 3361 ESLESRWTEL LSKAAARQKQ LEDILVLAKQ FHETAEPISD FLSVTEKKLA NSEPVGTQTA3420
 3421 KIQQQIIRHK ALEEDIENHA TDVHQAVKIG QSLSSLTSPA EQGVLSEKID SLQARYSEIQ3480
 3481 DRCCRKAALL DQALSNARLF GEDEVEVLNW LAEVEDKLSS VFVKDFKQDV LHRQHADHLA3540
 3541 LNEEIVNRKK NVDQAIKNGQ ALLKQTTGEE VLLIQEKLDG IKTRYADITV TSSKALRTLE3600
 3601 QARQLATKFQ STYEELTGWL REVEEELATS GGQSPTGEQI PQFQQRQKEL KKEVMEHRLV3660
 3661 LDTVNEVSRA LLELVPWRAR EGLDKLVSDA NEQYKLVSDT IGQRVDEIDA AIQRSQQYEQ3720
 3721 AADAELAWVA ETKRKLMALG PIRLEQDQTT AQLQVQKAFS IDIIRHKDSM DELFSHRSEI3780
 3781 FGTCGEEQKT VLQEKTESLI QQYEAISLLN SERYARLERA QVLVNQFWET YEELSPWIEE3840
 3841 TRALIAQLPS PAIDHEQLRQ QQEEMRQLRE SIAEHKPHID KLLKIGPQLK ELNPEEGEMV3900
 3901 EEKYQKAENM YAQIKEEVRQ RALALDEAVS QSTQITEFHD KIEPMLETLE NLSSRLRMPP3960
 3961 LIPAEVDKIR ECISDNKSAT VELEKLQPSF EALKRRGEEL IGRSQGADKD LAAKEIQDKL4020
 4021 DQMVFFWEDI KARAEEREIK FLDVLELAEK FWYDMAALLT TIKDTQDIVH DLESPGIDPS4080
 4081 IIKQQVEAAE TIKEETDGLH EELEFIRILG ADLIFACGET EKPEVRKSID EMNNAWENLN4140
 4141 KTWKERLEKL EDAMQAAVQY QDTLQAMFDW LDNTVIKLCT MPPVGTDLNT VKDQLNEMKE4200
 4201 FKVEVYQQQI EMEKLNHQGE LMLKKATDET DRDIIREPLT ELKHLWENLG EKIAHRQHKL4260
 4261 EGALLALGQF QHALEELMSW LTHTEELLDA QRPISGDPKV IEVELAKHHV LKNDVLAHQA4320
 4321 TVETVNKAGN ELLESSAGDD ASSLRSRLEA MNQCWESVLQ KTEEREQQLQ STLQQAQGFH4380
 4381 SEIEDFLLEL TRMESQLSAS KPTGGLPETA REQLDTHMEL YSQLKAKEET YNQLLDKGRL4440
 4441 MLLSRDDSGS GSKTEQSVAL LEQKWHVVSS KMEERKSKLE EALNLATEFQ NSLQEFINWL4500
 4501 TLAEQSLNIA SPPSLILNTV LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ LKFLSQKQDV4560
 4561 VLIKNLLVSV QSRWEKVVQR SIERGRSLDD ARKRAKQFHE AWKKLIDWLE DAESHLDSEL4620
 4621 EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY DTTIRTGRAL KEKTLLPEDS QKLDNFLGEV4680
 4681 RDKWDTVCGK SVERQHKLEE ALLFSGQFMD ALQALVDWLY KVEPQLAEDQ PVHGDLDLVM4740
 4741 NLMDAHKVFQ KELGKRTGTV QVLKRSGREL IENSRDDTTW VKGQLQELST RWDTVCKLSV4800
 4801 SKQSRLEQAL KQAEVFRDTV HMLLEWLSEA EQTLRFRGAL PDDTEALQSL IDTHKEFMKK4860
 4861 VEEKRVDVNS AVAMGEVILA VCHPDCITTI KHWITIIRAR FEEVLTWAKQ HQQRLETALS4920
 4921 ELVANAELLE ELLAWIQWAE TTLIQRDQEP IPQNIDRVKA LIAEHQTFME EMTRKQPDVD4980
 4981 RVTKTYKRKN IEPTHAPFIE KSRSGGRKSL SQPTPPPMPI LSQSEAKNPR INQLSARWQQ5040
 5041 VWLLALERQR KLNDALDRLE ELKEFANFDF DVWRKKYMRW MNHKKSRVMD FFRRIDKDQD5100
 5101 GKITRQEFID GILASKFPTT KLEMTAVADI FDRDGDGYID YYEFVAALHP NKDAYRPTTD5160
 5161 ADKIEDEVTR QVAQCKCAKR FQVEQIGENK YRFGDSQQLR LVRILRSTVM VRVGGGWMAL5220
 5221 DEFLVKNDPC RARGRTNIEL REKFILPEGA SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA5280
 5281 SQSNHSCTSM PSSPATPASG TKVIPSSGSK LKRPTPTFHS SRTSLAGDTS NSSSPASTGA5340
 5341 KTNRADPKKS ASRPGSRAGS RAGSRASSRR GSDASDFDLL ETQSACSDTS ESSAAGGQGN5400
 5401 SRRGLNKPSK IPTMSKKTTT ASPRTPGPKR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	Sample pIC145 from april 2005	Okada, M., et al. (2006)
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MACF1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: