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Protein Overview: SEC61A2

General Information:
Name(s) found: SEC61A2 [HGNC (HUGO)]
Description(s) found:
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  • gi|48477069|sp|Q9H9S3.3|S61A2_HUMAN RecName: Full=Protein transport protein Sec61 subunit alpha isoform 2; Short=Sec61 alpha-2 [NCBI NR]
  • gi|158258022|dbj|BAF84984.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|14589847|ref|NP_060614.2| Sec61 alpha form 2 isoform a [Homo sapiens] [NCBI NR]
  • gi|13517991|gb|AAK29084.1|AF346603_1 Sec61 alpha form 2 [Homo sapiens] [NCBI NR]
  • gi|119606730|gb|EAW86324.1| Sec61 alpha 2 subunit (S. cerevisiae), isoform CRA_b [Homo sapiens] [NCBI NR]
  • Sec61 alpha 2 subunit (S. cerevisiae) [HGNC (HUGO)]
  • Protein transport protein Sec61 subunit alpha isoform 2 OS=Homo sapiens GN=SEC61A2 PE=2 SV=3 [Swiss-Prot]
  • Sec61 alpha form 2 [HMR_022704.fasta]
  • Sec61a2 protein [Mus musculus]gi|34876835|ref|XP_341559.1| similar to Sec61 alpha isoform 2 [Rattus norvegicus]gi|10946604|ref|NP_067280.1| Sec61, alpha subunit 2 [Mus musculus]gi|14589847|ref|NP_060614.2| Sec61 alpha form 2 [Homo sapiens]gi|7673003|g [nrdb_11152004_Chlamydomonas]
  • Protein transport protein Sec61 alpha subunit isoform 2 (Sec61 alpha-2) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Sec61 alpha form 2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_018144) sec61 homolog; FLJ10578 protein [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Sec61 alpha form 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Sec61 alpha form 2 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Sec61 alpha 2 subunit (S. cerevisiae), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SEC61 ALPHA FORM 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Sec61 alpha form 2 isoform a [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SEC61A2 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00414427.2|SWISS-PROT:Q9H9S3-1|TREMBL:A8K8D0|ENSEMBL:ENSP00000368306|REFSEQ:NP_060614|H-INV:HIT000078131|VEGA:OTTHUMP00000019101 Tax_Id=9606 Gene_Symbol=SEC61A2 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SEC61A2 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 ENSG00000065665 IPI00641585 IPI00640481 IPI00647396 IPI00182313 IPI00414428 IPI00414427 IPI00643500 IPI00647854 IPI00854697 IPI00644876 IPI00640009 [drosphohumanreversed.fasta]
  • protein transport protein Sec61 subunit alpha isoform 2 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9H9S3;A8K8D0; RecName: Full=Protein transport protein Sec61 subunit alpha isoform 2; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 OS=Homo sapiens GN=SEC61A2 [011711_HMR.fasta]
  • IPI:IPI00414427.2|SWISS-PROT:Q9H9S3-1|ENSEMBL:ENSP00000298428|REFSEQ:NP_060614|H-INV:HIT000078131|VEGA:OTTHUMP00000019101 Tax_Id=9606 Gene_Symbol=SEC61A2 Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 2 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=SEC61A2 Synonyms=FLJ10578 protein transport protein Sec61 subunit alpha isoform 2 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Protein transport protein Sec61 subunit alpha isoform 2 GN=SEC61A2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 476 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKFLEVIK PFCAVLPEIQ KPERKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD  60
   61 PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
  121 MIITIGQAIV YVMTGMYGDP AEMGAGICLL IIIQLFVAGL IVLLLDELLQ KGYGLGSGIS 180
  181 LFIATNICET IVWKAFSPTT INTGRGTEFE GAVIALFHLL ATRTDKVRAL REAFYRQNLP 240
  241 NLMNLIATVF VFAVVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSN 300
  301 LYVISQMLSV RFSGNFLVNL LGQWADVSGG GPARSYPVGG LCYYLSPPES MGAIFEDPVH 360
  361 VVVYIIFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRDTSMV HELNRYIPTA 420
  421 AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQAEVGG MGALFF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..476] PSI-BLAST 71.045757 The structure of a protein conducting channel

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonucleoprotein binding
    		•  5.96221631042313 bayes_pls_golite062009
  • protein transporter activity
    		•  5.55929343005534 bayes_pls_golite062009
  • transporter activity
    		•  3.32223562584466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.22714325269757 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.76187269823414 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • binding
    		•  1.4562802789412 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.01893828721893 bayes_pls_golite062009
  • protein binding
    		•  0.674651002700028 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle