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Protein Overview: Epac-PC

General Information:
Name(s) found: Epac-PC / FBpp0111547 [FlyBase]
Description(s) found:
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  • gi|161076353|ref|NP_001097202.1| epac, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|157400207|gb|AAF57395.2| epac, isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene Epac is referred to in FlyBase by the symbol Dmel\Epac (CG34392, FBgn0085421). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2649417..2684421. It has the cytological map location 42D1. Based on sequence similarity, it is predicted to have molecular function</span>: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity; Rap guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of protein amino acid phosphorylation; regulation of small GTPase mediated signal transduction. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • type=protein; loc=2R:complement(2650152..2650279,2650339..2650688,2650972..2651105,2651326..2651496,2651556..2651809,2651880..2652241,2653041..2653202,2653440..2653616,2654556..2654700,2654920..2655065,2655627..2655819,2655874..2656015,2656084..2656170,26 [fly-100309-contam.fasta]
  • type=protein; loc=2R:complement(2650152..2650279,2650339..2650688,2650972..2651105,2651326..2651496,2651556..2651809,2651880..2652241,2653041..2653202,2653440..2653616,2654556..2654700,2654920..2655065,2655627..2655819,2655874..2656015,2656084..2656170,2656431..2656528,2656813..2656864,2661145..2661291,2679821..2679915,2679984..2680126,2684411..2684421); ID=FBpp0111547; name=Epac-PC; parent=FBgn0085421,FBtr0112635; dbxref=FlyBase:FBpp0111547,FlyBase_Annotation_IDs:CG34392-PC,REFSEQ:NP_001097202,GB_protein:AAF57395; MD5=59476343624290af1cf1cbccf734d77b; length=998; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(2650152..2650279,2650339..2650688,2650972..2651105,2651326..2651496,2651556..2651809,2651880..2652241,2653041..2653202,2653440..2653616,2654556..2654700,2654920..2655065,2655627..2655819,2655874..2656015,2656084..2656170,2656431..2656528,2656813..2656864,2661145..2661291,2679821..2679915,2679984..2680126,2684411..2684421); ID=FBpp0111547; name=Epac-PC; parent=FBgn0085421,FBtr0112635; dbxref=FlyBase:FBpp0111547,FlyBase_Annotation_IDs:CG34392-PC,REFSEQ:NP_001097202,GB_protein:AAF57395; MD5=59476343624290af1cf1cbccf734d77b; length=998; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Epac, isoform C OS=Drosophila melanogaster GN=Epac PE=4 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 998 amino acids

    Gene Ontology:
    Cellular Component: cAMP-dependent protein kinase complex [IEA]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    regulation of protein amino acid phosphorylation [IEA]
    Molecular Function: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity [ISS]
    Rap guanyl-nucleotide exchange factor activity [ISS]
    cAMP-dependent protein kinase regulator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKRPCDRNL RDVELISCRL RRVEPLCRLP GSALQQLAMC GFYEDLEKGV TLFRAGEQGR  60
   61 FWYAVLGGSL EVRYHAHADA DGKSAVTLCN LGVGATFGES VLHDLPRDST VVTKTTCELL 120
  121 RVEQQDFRLI WEKNKELMND IFTNCKLKNG FGPSVQATAA ATSPTKRPLS PDHPNPALPI 180
  181 TETPSPAMNR MGWALRTLLV ADNSSCLKDR KVSGKLIRKC APGTELVDWL VNLSPIVHTR 240
  241 AQAAGMWQAL LEEGVLAHVN KEQPFKDKCF LYRFRIDEEG GTAAAGVPQA EDLGAANEHI 300
  301 REALSALFQR GPDATLRMIL RKPSHERTSE ELELVFEELV HIAALSHLST SIKRELSSIF 360
  361 VFEAHAQAGT ILFNQGDEGR SWYILLKGSV DVVIHGKGTV ATLKTGDDFG KLALINDAPR 420
  421 AATIVLKENN CHLLRVDKEH FNRILRDVEA NTLRLQEHGK DVLVLERVAK QRGQHSAFKY 480
  481 TVMSGTPAKM LEHLLETRLG QSVGGMDPFL DDFLLTHIVF MPVVQLVDEL ANYFHCDAHE 540
  541 DAQTPEDREY IINFKKRVIQ FMQKWVMAVR HAAFEEPSVC DFIEDLAAEV EADPDLNEET 600
  601 SIVHNVLTQM ARYQEDRNQN AGQKWKLPPN GQPICLFSGN ATPSKTVIRP DDDIIFRVYC 660
  661 ADHTYCTLRF PMHTTAELIK ACAADKLQLN RGPEDLVLVE VKSNGERSVF KDNDVSIPTG 720
  721 LSLNGRLFVS VKDHLDALTQ LQEQECPTEG VDIDLEILST KELAYHITLF EWDLFWAVHE 780
  781 YELLYHTFGR HHFGKITANL DVFLRRFNEV QYWIVTELVS TPSLSKRVGL VRKFIKLAAY 840
  841 CKEYQNLNAF FAVVMGLSNM AVSRLQQTWE KIPSKFRKIF QEFEALIDPS RNHRAYRVFV 900
  901 GKLQPPLIPF MPLLLKDMTF AHEGNKTSLD GLVNFEKMHM MAQTMRTIRF CRSRSLGLEP 960
  961 PSPKSEGEVR SYISSFRVID NQRVLTAMSQ KVEPTRKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle