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Protein Overview: eIF4G-PB

General Information:
Name(s) found: eIF4G-PB / FBpp0111817 [FlyBase]
Description(s) found:
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  • gi|161076327|ref|NP_001096852.1| eukaryotic translation initiation factor 4G, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|157400025|gb|ABV53593.1| eukaryotic translation initiation factor 4G, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene eukaryotic translation initiation factor 4G is referred to in FlyBase by the symbol Dmel\eIF4G (CG10811, FBgn0023213). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:935911..951347. It has the cytological map location 102F1. There is experimental evidence that it has the molecular function</span>: RNA 7-methylguanosine cap binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; G1/S transition of mitotic cell cycle; mitotic spindle organization. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,948019..948777,950448..950525 [fly-100309-contam.fasta]
  • type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,948019..948777,950448..950525); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,948019..948777,950448..950525); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Eukaryotic translation initiation factor 4G, isoform B OS=Drosophila melanogaster GN=eIF4G PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=4:complement(936118..936179,936243..936344,936463..936685,936747..936893,937493..937716,937901..938369,938950..939107,939162..939402,939529..941825,945709..945764,946201..946312,946394..946574,946637..947287,948019..948777,950448..950525); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593,FlyMine:FBpp0111817,modMine:FBpp0111817; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=4:complement(join(929822..929899,927393..928151,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593,FlyMine:FBpp0111817,modMine:FBpp0111817; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=4:complement(join(929822..929899,927393..928151,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593,FlyMine:FBpp0111817,modMine:FBpp0111817; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Eukaryotic translation initiation factor 4G, isoform B OS=Drosophila melanogaster GN=eIF4G PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0111817 type=protein; loc=4:complement(join(929822..929899,927393..928151,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0111817; name=eIF4G-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593,FlyMine:FBpp0111817,modMine:FBpp0111817; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=4:complement(join(929822..929899,927393..928151,926011..926661,925768..925948,925575..925686,925083..925138,918903..921199,918536..918776,918324..918481,917275..917743,916867..917090,916121..916267,915837..916059,915617..915718,915492..915553)); ID=FBpp0111817; name=eIF4G1-PB; parent=FBgn0023213,FBtr0112904; dbxref=FlyBase:FBpp0111817,FlyBase_Annotation_IDs:CG10811-PB,REFSEQ:NP_001096852,GB_protein:ABV53593,UniProt/TrEMBL:A8DZ29,FlyMine:FBpp0111817,modMine:FBpp0111817; MD5=fdeced35ada94abd8eec00a96155cfa0; length=1919; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1919 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [ISS]
    cytosol [ISS]
    Biological Process: mitotic spindle elongation [IMP]
    RNA metabolic process [IEA]
    mitotic spindle organization [IMP]
    G1/S transition of mitotic cell cycle [IMP]
    translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]
    RNA 7-methylguanosine cap binding [IDA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQAIPTLPT QSDIDKAMQP HSAQNMILPA NKKTKKYDQQ VPTSKPQSLH QPLQPQHSHP  60
   61 TAQPQFQINK AYNVVSILKA SAQIAQQSPH LTNQQHPPIH HPQQTQQHQQ SYTNVVNRSL 120
  121 SASEPVRAQS SVICNGSSIL TVNSRQLNSG DMNSTAIYNI SSYRKLTGSL DGNVCFLNVQ 180
  181 DIKQNGNISG SVVSNKSIVG VGSEKSSCTG VSINNQIVLP NAQIGTSMGI AGTTTAGTSY 240
  241 MHEKNIVGVS VNCVNTSKKY DFNNSSLLSN NSYPASTAEY VSTGNNNSGN TRSNPQSGGI 300
  301 FRGPPSTPNA PRGASGGATR HVHVQPMYSQ PLHQNMVLQQ YTQYNPRQQT FPASHLQYAP 360
  361 APMPYYQYQY VPTLQQQPPH TRSAVTVNTN VNVGNNLQPV QSGPNGPLPV PGASSSQIQL 420
  421 LTSTVQPGAS TVMGVGGPGS TMGQVGVPPM VGVGVMTTSV QPQPVQVQPA SRRRHQHRLQ 480
  481 IIDPTTKKNI LDDFDKTKSN TDNEFSDQVT STNTPATVLS EGPIRIPQQE SVGLNNLTST 540
  541 SSQGSESRTN APYIPIETTP ISRTDVGPTP IVSAMTDAPS VEILPTPQRG RSKKIPIVSP 600
  601 KNVSESIVAP ITDETDDAGS TPISRATEES MPPNQTHPNL LISDSSKHKQ AVSNSEISKD 660
  661 APTGLKEMHV AELESSVASE NHPAGILDVN VNKSSQSLDF SADPEIDSIG AISPTSPNAV 720
  721 SPILHEVLDN TELSKKLENS TTERFKDSQS VEKPTHQELS LRNATDETEI SAMALQDVNS 780
  781 LDNNQIEKTY PSKPKLNVDV SEDISSRESA IKSTSTKNTG VDVGLQSDSK PETTLNDKQD 840
  841 STDLKVKVSA KISSIINYNE GQWSPNNPSG KKQYDREQLL QLREVKASRI QPEVKNVSIL 900
  901 PQPNLMPSFI RNNNNNKRVQ SMVGIIGNRS NESAGNYIGK QMSMSGVQSG GGRSSMKGMI 960
  961 HVNLSLNQDV KLSENENAWR PRVLNKSDGD SDAKSALEKD ELVRRVRGIL NKLTPERFDT1020
 1021 LVEEIIKLKI DTPDKVDEVI VLVFEKAIDE PNFSVSYARL CQRLAAEVKV IDERMESETK1080
 1081 SNSAHFRNAL LDKTEQEFTQ NVSQSTAKEK KLQPIVDKIK KCTDANEKAE LEAFLEEEER1140
 1141 KIRRRSGGTV RFIGELFKIS MLTGKIIYSC IDTLLNPHSE DMLECLCKLL TTVGAKFEKT1200
 1201 PVNSKDPSRC YSLEKSITRM QAIASKTDKD GARVSSRVRF MLQDVIDLRK NKWQTSRNEA1260
 1261 PKTMGQIEKE AKNEQLSAQY FGTLSSTTPG GSQGGSGKRD DRGNSRYGES RSSSAYGGSH1320
 1321 SQRGDNGNLR HQQQNNVGGN VSGGAGHSNG NNDENTWHVQ TSKGSRSLAV DSNKLEGLSK1380
 1381 LSDQNLETKK MGGLTQFIWI SSDTTRLSSA PTPTPSNPFA VLSSLIDKNS NERDRDRSGP1440
 1441 RNKGSYNKGS MERDRYDRGM HSRTGSSQGS RENSSSRGGQ QGRTLLSSSV QKSTSHSKYT1500
 1501 QQAPPTRHTV KAQSSVGSSN VNTGPLYRGS EQQTSATFSQ TTRSVAPVAV FIEASETDLK1560
 1561 LIKSVVSEIV DLSAASKEVT PGAVSCIKRV PEKLRCSFIY YILTDYLHLA NVGKQYRRYL1620
 1621 SIAVSQLIQQ NYISADHLRL AYNEFTVYAN DLIVDIPELW LYILQFAGPL IVKKILTISD1680
 1681 LWNNNLKENS PSNVAKKFLK TYLIYCTQEV GPNFARNMWI KFNLKWSDFM PESEVADFIK1740
 1741 FNRLEYVENE SKSPVIDHRE TPEKHVKNVI DHIEHLLKEG TTADCIIDYS NGNIMVVDKL1800
 1801 FIRGLTETLS NFSIHYKDNS YKLESETFQK FCIPVLQRYI DSNEDHQLEC LYTLQLLVHG1860
 1861 LEHPRGLLSE LIGELYDAFV IQKESLCKWR DSKDQSAGKG VAVKSLNPFF NSLLNDDAN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle