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Protein Overview: PARE_ECOLI

General Information:
Name(s) found: PARE_ECOLI [Swiss-Prot]
Description(s) found:
Found 7 descriptions.
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  • DNA topoisomerase 4 subunit B (EC 5.99.1.-) (Topoisomerase IV subunit B) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 630 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQTYNADAI EVLTGLEPVR RRPGMYTDTT RPNHLGQEVI DNSVDEALAG HAKRVDVILH  60
   61 ADQSLEVIDD GRGMPVDIHP EEGVPAVELI LCRLHAGGKF SNKNYQFSGG LHGVGISVVN 120
  121 ALSKRVEVNV RRDGQVYNIA FENGEKVQDL QVVGTCGKRN TGTSVHFWPD ETFFDSPRFS 180
  181 VSRLTHVLKA KAVLCPGVEI TFKDEINNTE QRWCYQDGLN DYLAEAVNGL PTLPEKPFIG 240
  241 NFAGDTEAVD WALLWLPEGG ELLTESYVNL IPTMQGGTHV NGLRQGLLDA MREFCEYRNI 300
  301 LPRGVKLSAE DIWDRCAYVL SVKMQDPQFA GQTKERLSSR QCAAFVSGVV KDAFILWLNQ 360
  361 NVQAAELLAE MAISSAQRRM RAAKKVVRKK LTSGPALPGK LADCTAQDLN RTELFLVEGD 420
  421 SAGGSAKQAR DREYQAIMPL KGKILNTWEV SSDEVLASQE VHDISVAIGI DPDSDDLSQL 480
  481 RYGKICILAD ADSDGLHIAT LLCALFVKHF RALVKHGHVY VALPPLYRID LGKEVYYALT 540
  541 EEEKEGVLEQ LKRKKGKPNV QRFKGLGEMN PMQLRETTLD PNTRRLVQLT IDDEDDQRTD 600
  601 AMMDMLLAKK RSEDRRNWLQ EKGDMAEIEV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..395] PSI-BLAST 136.0 Crystal Structure of E. coli Topoisomerase IV ParE 43kDa subunit complexed with ADPNP
    2 View Details [396..630] PSI-BLAST 51.39794 TOPOISOMERASE RESIDUES 410-1202,

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA topoisomerase (ATP-hydrolyzing) activity
    		•  2.32279006303682 bayes_pls_golite062009
  • binding
    		•  2.2777380001787 bayes_pls_golite062009
  • DNA topoisomerase activity
    		•  2.1147376780944 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05731599309128 bayes_pls_golite062009
  • DNA binding
    		•  1.99548954924236 bayes_pls_golite062009
  • catalytic activity
    		•  1.28862988439947 bayes_pls_golite062009
  • isomerase activity
    		•  0.673377410014343 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle