Protein Overview: NIRB_ECOLI

General Information:
Name(s) found:	NIRB_ECOLI [Swiss-Prot]
Description(s) found: Found 8 descriptions. SHOW ALL	Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4) - Escherichia coli [Swiss-Prot]
Organism:	Escherichia coli
Length:	847 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKVRLAIIG NGMVGHRFIE DLLDKSDAAN FDITVFCEEP RIAYDRVHLS SYFSHHTAEE  60
   61 LSLVREGFYE KHGIKVLVGE RAITINRQEK VIHSSAGRTV FYDKLIMATG SYPWIPPIKG 120
  121 SDTQDCFVYR TIEDLNAIES CARRSKRGAV VGGGLLGLEA AGALKNLGIE THVIEFAPML 180
  181 MAEQLDQMGG EQLRRKIESM GVRVHTSKNT LEIVQEGVEA RKTMRFADGS ELEVDFIVFS 240
  241 TGIRPRDKLA TQCGLDVAPR GGIVINDSCQ TSDPDIYAIG ECASWNNRVF GLVAPGYKMA 300
  301 QVAVDHILGS ENAFEGADLS AKLKLLGVDV GGIGDAHGRT PGARSYVYLD ESKEIYKRLI 360
  361 VSEDNKTLLG AVLVGDTSDY GNLLQLVLNA IELPENPDSL ILPAHSGSGK PSIGVDKLPD 420
  421 SAQICSCFDV TKGDLIAAIN KGCHTVAALK AETKAGTGCG GCIPLVTQVL NAELAKQGIE 480
  481 VNNNLCEHFA YSRQELFHLI RVEGIKTFEE LLAKHGKGYG CEVCKPTVGS LLASCWNEYI 540
  541 LKPEHTPLQD SNDNFLANIQ KDGTYSVIPR SPGGEITPEG LMAVGRIARE FNLYTKITGS 600
  601 QRLAMFGAQK DDLPEIWRQL IEAGFETGHA YAKALRMAKT CVGSTWCRYG VGDSVGLGVE 660
  661 LENRYKGIRT PHKMKFGVSG CTRECSEAQG KDVGIIATEK GWNLYVCGNG GMKPRHADLL 720
  721 AADIDRETLI KYLDRFMMFY IRTADKLTRT APWLENLEGG IDYLKAVIID DKLGLNAHLE 780
  781 EEMARLREAV LCEWTETVNT PSAQTRFKHF INSDKRDPNV QMVPEREQHR PATPYERIPV 840
  841 TLVEDNA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..430]	PSI-BLAST	74.69897	Dihydrolipoamide dehydrogenase
2	View Details	[431..743]	PSI-BLAST	54.0	Structure of spinach nitrite reductase
3	View Details	[744..847]	PSI-BLAST	55.0	SULFITE REDUCTASE STRUCTURE AT 1.6 ANGSTROM RESOLUTION

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
oxidoreductase activity, acting on NADH or NADPH	3.16996423124828	bayes_pls_golite062009
oxidoreductase activity	2.84234192551392	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.79314033427747	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.52244283583973	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.7514316327505	bayes_pls_golite062009
NADH dehydrogenase activity	0.520416738053292	bayes_pls_golite062009

2

Term	Confidence	Notes
oxidoreductase activity, acting on other nitrogenous compounds as donors	4.43988753106114	bayes_pls_golite062009
sulfite reductase (NADPH) activity	3.89379115110861	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	3.13268224304716	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.13576429179797	bayes_pls_golite062009
oxidoreductase activity	2.13548955338201	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.78567689421035	bayes_pls_golite062009
catalytic activity	1.39967796334655	bayes_pls_golite062009

3

Term	Confidence	Notes
oxidoreductase activity, acting on other nitrogenous compounds as donors	4.43988753106114	bayes_pls_golite062009
sulfite reductase (NADPH) activity	3.89379115110861	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	3.13268224304716	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.13576429179797	bayes_pls_golite062009
oxidoreductase activity	2.13548955338201	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.78567689421035	bayes_pls_golite062009
catalytic activity	1.39967796334655	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle