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Protein Overview: Clk-PD

General Information:
Name(s) found: Clk-PD / FBpp0099478 [FlyBase]
Description(s) found:
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  • gi|62472090|ref|NP_001014576.1| clock, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|61678474|gb|AAX52753.1| clock, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|47117813|sp|O61735.3|CLOCK_DROME RecName: Full=Circadian locomoter output cycles protein kaput; AltName: Full=dCLOCK; AltName: Full=dPAS1 [NCBI NR]
  • gi|45552989|ref|NP_996021.1| Clock CG7391-PC, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|45446003|gb|AAS65057.1| CG7391-PC, isoform C [Drosophila melanogaster] [NCBI NR]
  • (O61735) Circadian locomoter output cycles Kaput protein (dCLOCK) (dPAS1) [Swiss-Prot]
  • Circadian locomoter output cycles protein kaput OS=Drosophila melanogaster GN=Clk PE=1 SV=3 [Swiss-Prot]
  • The gene Clock is referred to in FlyBase by the symbol Dmel\Clk (CG7391, FBgn0023076). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:7757071..7768703. It has the cytological map location 66A12. There is experimental evidence that it has the molecular function</span>: protein binding; protein heterodimerization activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of circadian sleep/wake cycle, sleep; circadian rhythm; locomotor rhythm; positive regulation of transcription, DNA-dependent; circadian regulation of gene expression. 21 alleles are reported. The phenotype of these alleles is annotated with: larval lateral neuron. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • CG7391-PC, isoform C [Drosophila melanogaster]gi|47117813|sp|O61735|CLOC_DROME Circadian locomoter output cycles Kaput protein (dCLOCK) (dPAS1)gi|45552989|ref|NP_996021.1| CG7391-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:complement(7757313..7758818,7758881..7759503,7759563..7759919,7759973..7760189,7761569..7761750,7761810..7761970,7763123..7763160); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,F [fly-100309-contam.fasta]
  • Clock CG7391-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG7391-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Circadian locomoter output cycles protein kaput (dCLOCK) (dPAS1) [nr-271106-contam.fasta]
  • Clock CG7391-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG7391-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:complement(7757313..7758818,7758881..7759503,7759563..7759919,7759973..7760189,7761569..7761750,7761810..7761970,7763123..7763160); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:complement(7757313..7758818,7758881..7759503,7759563..7759919,7759973..7760189,7761569..7761750,7761810..7761970,7763123..7763160); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Circadian locomoter output cycles protein kaput OS=Drosophila melanogaster GN=Clk PE=2 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:complement(7757313..7758818,7758881..7759503,7759563..7759919,7759973..7760189,7761569..7761750,7761810..7761970,7763123..7763160); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753,FlyMine:FBpp0099478,modMine:FBpp0099478; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:complement(join(7770023..7770060,7768710..7768870,7768469..7768650,7766873..7767089,7766463..7766819,7765781..7766403,7764213..7765718)); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753,FlyMine:FBpp0099478,modMine:FBpp0099478; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:complement(join(7770023..7770060,7768710..7768870,7768469..7768650,7766873..7767089,7766463..7766819,7765781..7766403,7764213..7765718)); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753,FlyMine:FBpp0099478,modMine:FBpp0099478; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0099478 type=protein; loc=3L:complement(join(7770023..7770060,7768710..7768870,7768469..7768650,7766873..7767089,7766463..7766819,7765781..7766403,7764213..7765718)); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753,FlyMine:FBpp0099478,modMine:FBpp0099478; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:complement(join(7770023..7770060,7768710..7768870,7768469..7768650,7766873..7767089,7766463..7766819,7765781..7766403,7764213..7765718)); ID=FBpp0099478; name=Clk-PD; parent=FBgn0023076,FBtr0100132; dbxref=FlyBase_Annotation_IDs:CG7391-PD,FlyBase:FBpp0099478,GB_protein:AAX52753.1,REFSEQ:NP_001014576,GB_protein:AAX52753,UniProt/Swiss-Prot:O61735,FlyMine:FBpp0099478,modMine:FBpp0099478; MD5=991fc258aebcafebab79ebe1b8e35754; length=1027; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1027 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: eclosion rhythm [NAS][TAS]
    signal transduction [IEA]
    regulation of transcription, DNA-dependent [IEA]
    circadian rhythm [IMP][NAS][TAS]
    positive regulation of transcription from RNA polymerase II promoter [NAS][TAS]
    regulation of transcription [IEA]
    rhythmic behavior [TAS]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    circadian regulation of gene expression [IMP]
    behavioral response to cocaine [NAS][TAS]
    positive regulation of transcription, DNA-dependent [IGI][NAS][TAS]
    locomotor rhythm [IMP][NAS][TAS]
    regulation of circadian sleep/wake cycle, sleep [IMP]
    Molecular Function: DNA binding [IDA][NAS]
    transcription factor activity [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS][TAS]
    protein heterodimerization activity [IPI][NAS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDESDDKDD TKSFLCRKSR NLSEKKRRDQ FNSLVNDLSA LISTSSRKMD KSTVLKSTIA  60
   61 FLKNHNEATD RSKVFEIQQD WKPAFLSNDE YTHLMLESLD GFMMVFSSMG SIFYASESIT 120
  121 SQLGYLPQDL YNMTIYDLAY EMDHEALLNI FMNPTPVIEP RQTDISSSNQ ITFYTHLRRG 180
  181 GMEKVDANAY ELVKFVGYFR NDTNTSTGSS SEVSNGSNGQ PAVLPRIFQQ NPNAEVDKKL 240
  241 VFVGTGRVQN PQLIREMSII DPTSNEFTSK HSMEWKFLFL DHRAPPIIGY MPFEVLGTSG 300
  301 YDYYHFDDLD SIVACHEELR QTGEGKSCYY RFLTKGQQWI WLQTDYYVSY HQFNSKPDYV 360
  361 VCTHKVVSYA EVLKDSRKEG QKSGNSNSIT NNGSSKVIAS TGTSSKSASA TTTLRDFELS 420
  421 SQNLDSTLLG NSLASLGTET AATSPAVDSS PMWSASAVQP SGSCQINPLK TSRPASSYGN 480
  481 ISSTGISPKA KRKCYFYNNR GNDSDSTSMS TDSVTSRQSM MTHVSSQSQR QRSHHREHHR 540
  541 ENHHNQSHHH MQQQQQHQNQ QQQHQQHQQL QQQLQHTVGT PKMVPLLPIA STQIMAGNAC 600
  601 QFPQPAYPLA SPQLVAPTFL EPPQYLTAIP MQPVIAPFPV APVLSPLPVQ SQTDMLPDTV 660
  661 VMTPTQSQLQ DQLQRKHDEL QKLILQQQNE LRIVSEQLLL SRYTYLQPMM SMGFAPGNMT 720
  721 AAAVGNLGAS GQRGLNFTGS NAVQPQFNQY GFALNSEQML NQQDQQMMMQ QQQNLHTQHQ 780
  781 HNLQQQHQSH SQLQQHTQQQ HQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQLQLQQQ 840
  841 NDILLREDID DIDAFLNLSP LHSLGSQSTI NPFNSSSNNN NQSYNGGSNL NNGNQNNNNR 900
  901 SSNPPQNNNE DSLLSCMQMA TESSPSINFH MGISDDGSET QSEDNKMMHT SGSNLVQQQQ 960
  961 QQQQQQQILQ QHQQQSNSFF SSNPFLNSQN QNQNQLPNDL EILPYQMSQE QSQNLFNSPH1020
 1021 TAPGSSQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle