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Protein Overview: HFM1

General Information:
Name(s) found: HFM1 / YGL251C [SGD]
Description(s) found:
Found 8 descriptions.
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  • Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1046 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: synapsis [IGILink to PubMed article][IMPLink to PubMed article]
    DNA unwinding involved in replication [IDALink to PubMed article]
    meiosis [IDALink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSEAFPSIY ESNENCIISS PTGSGKTVLF ELAILRLIKE TNSDTNNTKI IYIAPTKSLC  60
   61 YEMYKNWFPS FVNLSVGMLT SDTSFLETEK AKKCNIIITT PEKWDLLTRR WSDYSRLFEL 120
  121 VKLVLVDEIH TIKEKRGASL EVILTRMNTM CQNIRFVALS ATVPNIEDLA LWLKTNNELP 180
  181 ANILSFDESY RQVQLTKFVY GYSFNCKNDF QKDAIYNSKL IEIIEKHADN RPVLIFCPTR 240
  241 ASTISTAKFL LNNHIFSKSK KRCNHNPSDK ILNECMQQGI AFHHAGISLE DRTAVEKEFL 300
  301 AGSINILCST STLAVGVNLP AYLVIIKGTK SWNSSEIQEY SDLDVLQMIG RAGRPQFETH 360
  361 GCAVIMTDSK MKQTYENLIH GTDVLESSLH LNLIEHLAAE TSLETVYSIE TAVNWLRNTF 420
  421 FYVRFGKNPA AYQEVNRYVS FHSVEDSQIN QFCQYLLDTL VKVKIIDISN GEYKSTAYGN 480
  481 AMTRHYISFE SMKQFINAKK FLSLQGILNL LATSEEFSVM RVRHNEKKLF KEINLSPLLK 540
  541 YPFLTEKKQS QIIDRVSQKV SLLIQYELGG LEFPSYEGAS KLHQTLVQDK FLVFRHCFRL 600
  601 LKCMVDTFIE KSDGTSLKNT LFLLRSLNGH CWENTPMVLR QLKTIGLVSV RRLIRHGITN 660
  661 LEEMGHLSDT QIEYYLNLKI GNGIKIKNDI SLLPCLNIRT KLENCKIENE ELWLTFKVEI 720
  721 SATFKSSIWH GQHLSLDIET EKSSGELIDF RRLQVNKLQS PRGFRISAKI SPKLEKIEFS 780
  781 IHCQEIAGLG KTIVYSTDHL ASQFSAKTPN IRKDLNSLEK CLFYESSSDG EVGKTSRVSH 840
  841 KDGLEESLSS DDSILDYLNE RKKSSKAVES AAVIHPEAHS SSHFSNGRQV RSNGNYECFH 900
  901 SCKDKTQCRH LCCKEGIPVK YIKEKGPSSI KPVSKPDQIR QPLLAKNINT TPHLEKRLNS 960
  961 KPKQWQEENT DIATVHTLPS KIYNLSQQMS SMEAGEQVLK SGPENCPEII PIDLESSDSY1020
 1021 SSNTAASSIS DPNGDLDFLG SDIEFE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 79.0 Putative DEAD box RNA helicase
    2 View Details [191..381] PSI-BLAST 79.0 Putative DEAD box RNA helicase
    3 View Details [382..469] PSI-BLAST 10.154902 Nucleotide excision repair enzyme UvrB
    4 View Details [470..829] Pfam 97.091515 Sec63 domain No confident structure predictions are available.
    5 View Details [830..1046] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle