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Protein Overview: UGO1

General Information:
Name(s) found: UGO1 / YDR470C [SGD]
Description(s) found:
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  • pir||S69637 hypothetical protein YDR470c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • UGO1 - similarity to chromosome segregation protein Cse1p [mips]
  • Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion [SGD]
  • hypothetical protein YDR470c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • [chemostatdb.fasta]
  • Mitochondrial fusion and transport protein UGO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGO1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UGO1 SGDID:S000002878, Chr IV from 1401214-1399706, Genome Release 64-1-1, reverse complement, Verified ORF, "Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion" [yeast-030211-contam.fasta]
  • UGO1 SGDID:S000002878, Chr IV from 1401214-1399706, Genome Release 64-2-1, reverse complement, Verified ORF, "Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter" [20141208_orf_trans.fasta]
  • YDR470C SGDID:S000002878, Chr IV from 1401214-1399706, Genome Release 64-1-1, reverse complement, Verified ORF, "Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: filamentous growth [IMPLink to PubMed article]
    mitochondrial fusion [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    transport [ISSLink to PubMed article]
    mitochondrial genome maintenance [IMPLink to PubMed article]
    Molecular Function: transporter activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNNVTEAT SRAQIRPYYD PDSFNAGYSA VFKPDEGVVD PHGYTIASKL NVINSSPTTK  60
   61 RMANALFKSS PMKKLSNSVN DGLSLEGSNG EITGLNNFEW AELVNIQKWR KIFEQLLDMF 120
  121 FRKYFQLLIQ QPFDVARLLI QVGEFKIFKT TVDTNKPQAP IILRDEEGDG AAREGEEDAY 180
  181 DEEEIDFFPI ERKIAEANST APIMAEETDH SHHEPTDISL TIAPQSLHTI DVINALFDQE 240
  241 GIRGLWKANN TTFIYNFLSL SIDTWFTGLL SSFLGVPDPY FMEVINSPDI SKSFILALGA 300
  301 GVFTSIILLP VDLIRTRLIV TSFKKKKNVK TDGKNMVTNT RSLRQLIRCW SWRKNGVSIP 360
  361 LDMWSLTILQ SINNSFFNKL FDLVIYNQFH IEKYSQTVMY NTMKFFSKSL ELFIKLPLEN 420
  421 LLRRCQLNYL LNDQRLSFKV DSTELIVKPK KYNGIWDVIR NNSNTNRGQL WNGWKVGVIS 480
  481 LICGYGLQMM NKVDINMEQE KF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] deduced N/A No confident structure predictions are available.
    2 View Details [168..502] MSA 305.468989 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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