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Protein Overview: TOP3A_ARATH

General Information:
Name(s) found: TOP3A_ARATH [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • DNA topoisomerase 3-alpha OS=Arabidopsis thaliana GN=TOP3A PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 926 amino acids

    Gene Ontology:
    Cellular Component: chromosome [IEA]
    Biological Process: DNA repair [IMP]
    resolution of meiotic recombination intermediates [IMP]
    chromosome segregation [IMP]
    mitosis [IMP]
    DNA topological change [ISS]
    DNA unwinding involved in replication [ISS]
    meiosis [IMP]
    Molecular Function: nucleic acid binding [IEA]
    DNA binding [IEA][ISS]
    zinc ion binding [IEA]
    DNA topoisomerase activity [IEA][ISS]
    DNA topoisomerase type I activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRGGGPVT VLNVAEKPSV AKSVAGILSR GTFRTREGRS RYNKIFEFDY AINGQPCRML  60
   61 MTSVIGHLME LEFADRYRKW HSCDPADLYQ APVMKHVPED KKDIKKTLEE EARKSDWLVL 120
  121 WLDCDREGEN IAFEVVDVCR AVKHNLFIRR AHFSALIDRD IHEAVQNLRD PNQLFAEAVD 180
  181 ARQEIDLRIG ASFTRFQTML LRDRFAIDST GEERSRVISY GPCQFPTLGF IVERYWEIQA 240
  241 HEPEEFWTIN CSHQSEEGLA TFNWMRGHLF DYASAVILYE MCVEEPTATV MNVPHPRERF 300
  301 KYPPYPLNTI ELEKRASRYF RLSSEHTMKV AEELYQAGFI SYPRTETDSF SSRTDLRAMV 360
  361 EEQTRHPAWG SYAQRLLEPE GGLWRNPANG GHDDKAHPPI HPTKFSSGES NWSRDHLNVY 420
  421 ELVVRHYLAC VSQPAVAAET TVEIDIAGER FSASGRAILA KNYLEVYRFE SWGGSVIPVY 480
  481 EKGQQFIPTT LTLDAAVTRP PPLLCEADLL SCMDKAGIGT DATMHDHIKK LLDRGYATKD 540
  541 ANTRFSPTNL GEALVMGYDD MGYELWKPNL RALMEHDMNE VSVGRKTKAE VLETCLQQMK 600
  601 ACFLDARVKK SKLLEAMTIF FERSNNTDES ESQTAGEVVR RCNLCNESDM ALRKNRDGNF 660
  661 MVGCMNYPQC RNAVWLPGPT LEASVTTNVC QSCGPGPVYK ILFKFRQIGI PPGFDVNHLG 720
  721 CVGGCDDILK QLIDICGTGS RSQARRTPGT APSNNIQGSN TRQSNVCIHC QQRGHASTNC 780
  781 PSRVPASRNS RPTATNPRND ESTVSCNTCG SQCVLRTANT EANRGRQFFS CPTQGCSFFA 840
  841 WEDSINNSSG NATTGSNSGG SGRRGSRGRG RGGRGGQSSG GRRGSGTSFV SATGEPVSGI 900
  901 RCFSCGDPSH FANACPNRNN SNGNYF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..675] PSI-BLAST 174.0 DNA topoisomerase I, 67K N-terminal domain
    2 View Details [676..764] deduced N/A No confident structure predictions are available.
    3 View Details [765..926] PSI-BLAST 42.30103 No description for 2i13A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

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