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Protein Overview: TOP2_ARATH

General Information:
Name(s) found: TOP2_ARATH [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • DNA topoisomerase 2 OS=Arabidopsis thaliana GN=TOP2 PE=2 SV=2 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 1473 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    DNA topoisomerase complex (ATP-hydrolyzing) [ISS]
    Biological Process: chromosome segregation [ISS]
    DNA topological change [ISS]
    DNA metabolic process [ISS]
    Molecular Function: ATP binding [ISS]
    DNA binding [ISS]
    DNA-dependent ATPase activity [ISS]
    DNA topoisomerase activity [ISS]
    DNA topoisomerase (ATP-hydrolyzing) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKLPLQNS NAANVAKAPA KSRAAAGGKT IEEMYQKKSQ LEHILLRPDT YIGSIEKHTQ  60
   61 TLWVYEKDEM VQRPVTYVPG LYKIFDEILV NAADNKQRDA KMDSVQVVID VEQNLISVCN 120
  121 SGAGVPVEIH QEEGIYVPEM IFGHLLTSSN YDDNVKKTTG GRNGYGAKLT NIFSTEFIIE 180
  181 TADGKRLKKY KQVFENNMGK KSEPVITKCN KSENWTKVTF KPDLKKFNMT ELEDDVVALM 240
  241 SKRVFDIAGC LGKSVKVELN GKQIPVKSFT DYVDLYLSAA NKSRTEDPLP RLTEKVNDRW 300
  301 EVCVSLSEGQ FQQVSFVNSI ATIKGGTHVD YVTSQITNHI VAAVNKKNKN ANVKAHNVKN 360
  361 HLWVFVNALI DNPAFDSQTK ETLTLRQSSF GSKCELSEDF LKKVGKSGVV ENLLSWADFK 420
  421 QNKDLKKSDG AKTGRVLVEK LDDAAEAGGK NSRLCTLILT EGDSAKSLAL AGRSVLGNNY 480
  481 CGVFPLRGKL LNVREASTTQ ITNNKEIENL KKILGLKQNM KYENVNSLRY GQMMIMTDQD 540
  541 HDGSHIKGLL INFIHSFWPS LLQVPSFLVE FITPIVKATR KGTKKVLSFY SMPEYEEWKE 600
  601 SLKGNATGWD IKYYKGLGTS TAEEGKEYFS NLGLHKKDFV WEDEQDGEAI ELAFSKKKIE 660
  661 ARKNWLSSYV PGNHLDQRQP KVTYSDFVNK ELILFSMADL QRSIPSMVDG LKPGQRKILF 720
  721 VAFKKIARKE MKVAQLVGYV SLLSAYHHGE QSLASAIIGM AQDYVGSNNI NLLLPNGQFG 780
  781 TRTSGGKDSA SARYIFTKLS PVTRILFPKD DDLLLDYLNE DGQRIEPTWY MPIIPTVLVN 840
  841 GAEGIGTGWS TFIPNYNPRE IVANVRRLLN GESMVPMDPW YRGFKGTIEK TASKEGGCTY 900
  901 TITGLYEEVD ETTIRITELP IRRWNDDYKN FLQSLKTDNG APFFQDVKAY NDEKSVDFDL 960
  961 ILSEENMLAA RQEGFLKKFK LTTTIATSNM HLFDKKGVIK KYVTPEQILE EFFDLRFEYY1020
 1021 EKRKETVVKN MEIELLKLEN KARFILAVLS GEIIVNKRKK ADIVEDLRQK GFTPFPRKAE1080
 1081 SVEAAIAGAV DDDAAEEPEE ILVDPESSSS YIPGSEYDYL LAMAIASLTI EKVEELLADR1140
 1141 DKMIIAVADM KKTTPKSLWL SDLESLDKEL EKLDLKDAQV QQAIEAAQKK IRAKSGAAVK1200
 1201 VKRQAPKKPA PKKTTKKASE SETTEASYSA MDTDNNVAEV VKPKARQGAK KKASESETTE1260
 1261 ASHSAMDTDN NVAEVVKPKG RQGAKKKAPA AAKEVEEDEM LDLAQRLAQY NFGSAPADSS1320
 1321 KTAETSKAIA VDDDDDDVVV EVAPVKKGGR KPAATKAAKP PAAPRKRGKQ TVASTEVLAI1380
 1381 GVSPEKKVRK MRSSPFNKKS SSVMSRLADN KEEESSENVA GNSSSEKSGG DVSAISRPQR1440
 1441 ANRRKMTYVL SDSESESAND SEFDDIEDDE DDE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..438] PSI-BLAST 122.0 Human Topo IIa ATPase/AMP-PNP
    2 View Details [439..703] PSI-BLAST 165.0 No description for 2rgrA was found.
    3 View Details [704..1473] PSI-BLAST 132.0 Structure of the full-length E. coli ParC subunit


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle