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Protein Overview: HMDH1_ARATH

General Information:
Name(s) found: HMDH1_ARATH [Swiss-Prot]
Description(s) found:
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  • pir||A32107 hydroxymethylglutaryl-CoA reductase (NADPH2) (EC 1.1.1.34) - Arabidopsis thaliana [NCBI NR]
  • gi|6554470|gb|AAF16652.1|AC012394_1 hydroxy methylglutaryl CoA reductase (AA 1-592); 9510-7255 [Arabidopsis thaliana] [NCBI NR]
  • gi|388556|gb|AAA32814.1| hydroxymethylglutaryl CoA reductase [NCBI NR]
  • gi|34365559|gb|AAQ65091.1| At1g76490/F15M4.1 [Arabidopsis thaliana] [NCBI NR]
  • gi|23397126|gb|AAN31847.1| putative 3-hydroxy-3-methylglutaryl CoA reductase [Arabidopsis thaliana] [NCBI NR]
  • gi|166750|gb|AAA76821.1| 3-hydroxy-3-methylglutaryl CoA reductase [NCBI NR]
  • gi|16336|emb|CAA33139.1| unnamed protein product [Arabidopsis thaliana] [NCBI NR]
  • ref|NP_177775.1| 3-hydroxy-3-methylglutaryl-CoA reductase 1 / HMG-CoA reductase 1 (HMG1) [Arabidopsis thaliana] [NCBI NR]
  • gi|14326475|gb|AAK60283.1|AF385690_1 At1g76490/F15M4.1 [Arabidopsis thaliana] [NCBI NR]
  • gi|123340|sp|P14891.1|HMDH1_ARATH RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase 1; Short=HMG-CoA reductase 1; Short=HMGR1 [NCBI NR]
  • gi|12323986|gb|AAG51957.1|AC015450_18 3-hydroxy-3-methylglutaryl CoA reductase (AA 1-592); 32253-34508 [Arabidopsis thaliana] [NCBI NR]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 OS=Arabidopsis thaliana GN=HMG1 PE=1 SV=1 [Swiss-Prot]
  • (P14891) 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (EC 1.1.1.34) (HMG-CoA reductase 1) (HMGR1) [Swiss-Prot]
  • At1g76490/F15M4.1 [Arabidopsis thaliana]gi|23397126|gb|AAN31847.1| putative 3-hydroxy-3-methylglutaryl CoA reductase [Arabidopsis thaliana]gi|16336|emb|CAA33139.1| unnamed protein product [Arabidopsis thaliana]gi|12323986|gb|AAG51957.1| 3-hydroxy-3-met [nrdb_11152004_Chlamydomonas]
  • putative 3-hydroxy-3-methylglutaryl CoA reductase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • hydroxy methylglutaryl CoA reductase (AA 1-592); 9510-7255 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA reductase 1) (HMGR1) [nr-271106-contam.fasta]
  • At1g76490/F15M4.1 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • hydroxymethylglutaryl CoA reductase [nr-271106-contam.fasta]
  • unnamed protein product [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • 3-hydroxy-3-methylglutaryl CoA reductase (AA 1-592); 32253-34508 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • 3-hydroxy-3-methylglutaryl CoA reductase [nr-271106-contam.fasta]
    • Organism: Arabidopsis thaliana
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: [NOT]peroxisome [IDA]
    membrane [TAS]
    endoplasmic reticulum [IDA]
    [NOT]plastid [IDA]
    Biological Process: isoprenoid biosynthetic process [ISS][TAS]
    sterol biosynthetic process [IMP]
    Molecular Function: hydroxymethylglutaryl-CoA reductase activity [IGI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLRRRPPKP PVTNNNNSNG SFRSYQPRTS DDDHRRRATT IAPPPKASDA LPLPLYLTNA  60
   61 VFFTLFFSVA YYLLHRWRDK IRYNTPLHVV TITELGAIIA LIASFIYLLG FFGIDFVQSF 120
  121 ISRASGDAWD LADTIDDDDH RLVTCSPPTP IVSVAKLPNP EPIVTESLPE EDEEIVKSVI 180
  181 DGVIPSYSLE SRLGDCKRAA SIRREALQRV TGRSIEGLPL DGFDYESILG QCCEMPVGYI 240
  241 QIPVGIAGPL LLDGYEYSVP MATTEGCLVA STNRGCKAMF ISGGATSTVL KDGMTRAPVV 300
  301 RFASARRASE LKFFLENPEN FDTLAVVFNR SSRFARLQSV KCTIAGKNAY VRFCCSTGDA 360
  361 MGMNMVSKGV QNVLEYLTDD FPDMDVIGIS GNFCSDKKPA AVNWIEGRGK SVVCEAVIRG 420
  421 EIVNKVLKTS VAALVELNML KNLAGSAVAG SLGGFNAHAS NIVSAVFIAT GQDPAQNVES 480
  481 SQCITMMEAI NDGKDIHISV TMPSIEVGTV GGGTQLASQS ACLNLLGVKG ASTESPGMNA 540
  541 RRLATIVAGA VLAGELSLMS AIAAGQLVRS HMKYNRSSRD ISGATTTTTT TT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] MSA 3.015971 View MSA. No confident structure predictions are available.
    2 View Details [121..592] PSI-BLAST 1000.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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