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Protein Overview: TOP1_BACSU

General Information:
Name(s) found: TOP1_BACSU [Swiss-Prot]
Description(s) found:
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  • pir||G69724 DNA topoisomerase I topA - Bacillus subtilis [NCBI NR]
  • gi|730965|sp|P39814.1|TOP1_BACSU RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; AltName: Full=Omega-protein; AltName: Full=Relaxing enzyme; AltName: Full=Untwisting enzyme; AltName: Full=Swivelase [NCBI NR]
  • gi|520753|gb|AAA22763.1| DNA topoisomerase I [Bacillus subtilis] [NCBI NR]
  • gi|2462970|emb|CAA04422.1| DNA Topoisomerase I [Bacillus subtilis] [NCBI NR]
  • DNA topoisomerase 1 OS=Bacillus subtilis GN=topA PE=3 SV=1 [Swiss-Prot]
  • 691 aa - DNA topoisomerase I [subtilist_Price.fasta]
  • DNA topoisomerase I [Bacillus subtilis subsp. subtilis str. 168]gi|2462970|emb|CAA04422.1| DNA Topoisomerase I [Bacillus subtilis]gi|2633984|emb|CAB13485.1| DNA topoisomerase I [Bacillus subtilis subsp. subtilis str. 168]gi|7449002|pir||G69724 DNA topo [nrdb_11152004_Chlamydomonas]
  • DNA topoisomerase I [nr-271106-contam.fasta]
  • DNA topoisomerase 1 (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase) [nr-271106-contam.fasta]
  • DNA topoisomerase 1 OS=Bacillus subtilis (strain 168) GN=topA PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Bacillus subtilis
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDYLVIVES PAKAKTIERY LGKKYKVKAS MGHVRDLPKS QMGVDIEQNF EPKYITIRGK  60
   61 GPVLKELKTA AKKAKKVYLA ADPDREGEAI AWHLAHSLDL DLNSDCRVVF NEITKDAIKE 120
  121 SFKHPRMINM DLVDAQQARR ILDRLVGYKI SPILWKKVKK GLSAGRVQSV ALRLIIDREK 180
  181 EINDFKPEEY WTIDGTFLKG QETFEASFFG KNGKKLPLNS EADVKEILSQ LKGNQYTVEK 240
  241 VTKKERKRNP ALPFTTSTLQ QEAARKLNFR AKKTMMIAQQ LYEGIDLGRE GTVGLITYMR 300
  301 TDSTRISNTA VDEAAAFIDQ TYGKEFLGGK RKPAKKNENA QDAHEAIRPT SVLRKPSELK 360
  361 AVLGRDQMRL YKLIWERFVA SQMAPAVLDT MSVDLTNNGL TFRANGSKVK FSGFMKVYVE 420
  421 GKDDQMEEKD RMLPDLQEGD TVLSKDIEPE QHFTQPPPRY TEARLVKTLE ERGIGRPSTY 480
  481 APTLDTIQRR GYVALDNKRF VPTELGQIVL DLIMEFFPEI INVEFTAKME RDLDHVEEGN 540
  541 TEWVKIIDNF YTDFEKRVKK AESEMKEVEI EPEYAGEDCE LCSSPMVYKM GRYGKFLACS 600
  601 NFPDCRNTKP IVKQIGVKCP SCGEGNIVER KSKKKRVFYG CDRYPDCEFV SWDKPIERKC 660
  661 PKCGKMLVEK KLKKGIQVQC VECDYKEEPQ K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..575] PSI-BLAST 1000.0 DNA topoisomerase I, 67K N-terminal domain
    2 View Details [576..691] FFAS03 1.02 RBP9 subunit of RNA polymerase II

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  9.28485802237784 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  6.20416707013367 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.37048693883188 bayes_pls_golite062009
  • DNA binding
    		•  3.2732257752308 bayes_pls_golite062009
  • binding
    		•  3.07618319631815 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle