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Protein Overview: sphk-1

General Information:
Name(s) found: sphk-1 / CE35833 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00007918 locus:sphk-1 Sphingosine kinase 1 status:Confirmed UniProt:Q18425 protein_id:CAE48497.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEALink to PubMed article]
    Molecular Function: diacylglycerol kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGTICCCCR SDAEENEQLT SVILSRKPPP QEQCRGNLLV FINPNSGTGK SLETFANTVG  60
   61 PKLDKSLIRY EVVVTTGPNH ARNVLMTKAD LGKFNGVLIL SGDGLVFEAL NGILCREDAF 120
  121 RIFPTLPIGI VPSGSGNGLL CSVLSKYGTK MNEKSVMERA LEIATSPTAK AESVALYSVK 180
  181 TDNQSYASFL SIGWGLMADI DIDSEKWRKS LGHHRFTVMG FIRSCNLRSY KGRLTYRPYK 240
  241 PKGFHPSSNV FSVYEKTTQQ RIDDSKVKTN GSVSDSEEET METKFQNWTL PDSDETLAVG 300
  301 SSDLEETVVI EDNFVNIYAV TLSHIAADGP FAPSAKLEDN RIHLSYILWK DIGTRVNIAK 360
  361 YLLAIEHETH LDLPFVKHVE VSSMKLEVIS EGSHVVLDGE VVDTKTIEVA STKNHISVFS 420
  421 STA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..326] PSI-BLAST 31.0 No description for 2bonA was found.
    2 View Details [327..423] FFAS03 2.31 No description for 2bonA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • kinase activity
    		•  2.76633393386992 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.49560915337842 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.43985991144271 bayes_pls_golite062009
  • transferase activity
    		•  1.63159199531284 bayes_pls_golite062009
  • catalytic activity
    		•  0.33446102778142 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle