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Protein Overview: sym-2

General Information:
Name(s) found: sym-2 / CE35148 [WormBase]
Description(s) found:
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  • WBGene00006367 locus:sym-2 RNA-binding protein sym-2 status:Confirmed UniProt:Q22708 protein_id:CAA93887.2 [WormBase]
  • gi|74966269|sp|Q22708.3|SYM2_CAEEL RecName: Full=RNA-binding protein sym-2; AltName: Full=Synthetic lethal with mec-8 protein 2 [NCBI NR]
  • gi|71998567|ref|NP_495960.2| SYnthetic lethal with Mec family member (sym-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|33300449|emb|CAA93887.2| C. elegans protein ZK1067.6, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|33300362|emb|CAA92704.2| C. elegans protein ZK1067.6, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|29165341|gb|AAO65265.1| putative RNA binding protein SYM-2 [Caenorhabditis elegans] [NCBI NR]
  • RNA-binding protein sym-2 OS=Caenorhabditis elegans GN=sym-2 PE=2 SV=3 [Swiss-Prot]
  • [wormpep111.fasta]
  • putative RNA binding protein SYM-2 [Caenorhabditis elegans]gi|33300449|emb|CAA93887.2| Hypothetical protein ZK1067.6 [Caenorhabditis elegans]gi|33300362|emb|CAA92704.2| Hypothetical protein ZK1067.6 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE35148 WBGene00006367 locus:sym-2 hnRNP F protein like status:Confirmed TR:Q22708 protein_id:CAA93887.2 [wormpep150.fasta]
  • 35148 WBGene00014211 hnRNP F protein like status:Confirmed TR:Q22708 protein_id:CAA93887.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE35148 WBGene00014211 hnRNP F protein like status:Confirmed TR:Q22708 protein_id:CAA93887.2 [wormpep132.fasta]
  • 35148 WBGene00006367 locus:sym-2 hnRNP F protein like status:Confirmed TR:Q22708 protein_id:CAA93887.2 [wormpep150-phg-orf-ecoli-rand.fasta]
  • hnRNP F protein like status:Confirmed TN:CAA93887 protein_id:CAA93887.2 [wormpep115.fasta.reversed]
  • CE35148 WBGene00006367 locus:sym-2 hnRNP F protein like status:Confirmed UniProt:Q22708_CAEEL protein_id:CAA93887.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE35148 WBGene00006367 locus:sym-2 hnRNP F protein like status:Confirmed UniProt:Q22708_CAEEL protein_id:CAA93887.2| [wormORF-contam.fasta]
  • putative RNA binding protein SYM-2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein ZK1067.6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • SYnthetic lethal with Mec family member (sym-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE35148 WBGene00006367 locus:sym-2 hnRNP F protein like status:Confirmed UniProt:Q22708 protein_id:CAA93887.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE35148 WBGene00006367 locus:sym-2 status:Confirmed RNA-binding protein sym-2 [wormpep246-ecoli-contam.fasta]
  • CE35148 WBGene00006367 locus:sym-2 status:Confirmed UniProt:Q22708 protein_id:CAA93887.2 RNA-binding protein sym-2 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 618 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: embryonic development ending in birth or egg hatching [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    embryonic body morphogenesis [IGILink to PubMed articleLink to PubMed article]
    regulation of RNA splicing [ISSLink to PubMed article]
    multicellular organismal movement [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRQTSHPEQ RLLLIRVSDG NYDENTKLVV TSFYPRRQED ANNNSTSPSS ASSSGSEIST  60
   61 RLVNITPEDV VKFFDEHPTS SYIFTKGPEP IRHVLIPLFA RNELCVPHPL HHYYDIKHLY 120
  121 YGNQEEDGME QEEIEDDVAI ARAILDMDDE LLEKTHQFVN IEYQPAPILE DQEVGADGDN 180
  181 VVCRARGLPW QASDHHVAQF FAGLDIVPGG IALCLSSEGR RNGEVLVQFS SQESRDLALK 240
  241 RHRNFLLSRY IEVYKAGLDE FMHVATGSST EAMEFVSANA IIVRMRGLPY DCTDAQIRTF 300
  301 FEPLKLTDKI LFITRTDGRP TGDAFVQFET EEDAQQGLLK HRQVIGQRYI ELFKSTAAEV 360
  361 QQVVKRCNLI NSSPAVANAV EAPEEKKKDC VRLRGLPYEA TVQHIVTFLG DFATMVKFQG 420
  421 VHMVYNNQGH PSGEAFIQMI NEQAASACAA GVHNNFMSVG KKKRYIEVFQ ASAEELNLHH 480
  481 LVGQQHQVPP PAPLGFMGQL PPQAPQPQQF WSSYPSPPIS PIVPGQVTQL IIYGIHMSIG 540
  541 VPELVANFTT PEHTVDNVLF TRWPTHLCPG EAILTLRNRG APPPQTSPLS QISQLSAPNF 600
  601 AAYSHHPQNF PLQPILME

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..173] PSI-BLAST 20.221849 Nucleolin
    3 View Details [174..370] PSI-BLAST 45.30103 Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
    4 View Details [371..511] PSI-BLAST 4.221849 Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
    5 View Details [512..618] PSI-BLAST 18.0 NMR solution structure of TcUBP1, a single RBD-unit from Trypanosoma cruzi

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.30587477666777 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.2660519582186 bayes_pls_golite062009
  • protein binding
    		•  0.88951142240317 bayes_pls_golite062009
  • RNA binding
    		•  0.498012521772139 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.30587477666777 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.2660519582186 bayes_pls_golite062009
  • protein binding
    		•  0.88951142240317 bayes_pls_golite062009
  • RNA binding
    		•  0.498012521772139 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.30587477666777 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.2660519582186 bayes_pls_golite062009
  • protein binding
    		•  0.88951142240317 bayes_pls_golite062009
  • RNA binding
    		•  0.498012521772139 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle