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Protein Overview: let-49

General Information:
Name(s) found: let-49 / CE28136 [WormBase]
Description(s) found:
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  • WBGene00002324 locus:let-49 Mediator of RNA polymerase II transcription subunit 7 status:Confirmed UniProt:Q95Q17 protein_id:CAC42382.1 [WormBase]
  • gi|75019445|sp|Q95Q17.1|MED7_CAEEL RecName: Full=Mediator of RNA polymerase II transcription subunit 7; AltName: Full=Mediator complex subunit 7; AltName: Full=CeMED7; Short=MED-7; AltName: Full=Lethal protein 49 [NCBI NR]
  • gi|17510289|ref|NP_493586.1| LEThal family member (let-49) [Caenorhabditis elegans] [NCBI NR]
  • gi|14530637|emb|CAC42382.1| C. elegans protein Y54E5B.3b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Mediator of RNA polymerase II transcription subunit 7 OS=Caenorhabditis elegans GN=let-49 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE28136 WBGene00002324 locus:let-49 status:Confirmed TR:Q95Q17 protein_id:CAC42382.1 [wormpep150.fasta]
  • 28136 WBGene00002324 locus:let-49 status:Confirmed TR:Q95Q17 protein_id:CAC42382.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • cofactor required for Sp1 transcriptional activation 33kDa, LEThal LET-49 (let-49) [Caenorhabditis elegans]gi|14530637|emb|CAC42382.1| Hypothetical protein Y54E5B.3b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:let-49 status:Confirmed TR:Q95Q17 protein_id:CAC42382.1 [wormpep115.fasta.reversed]
  • CE28136 status:Confirmed TR:Q95Q17 protein_id:CAC42382.1 [wormpep80.hongbin]
  • CE28136 WBGene00002324 locus:let-49 status:Confirmed UniProt:Q95Q17 protein_id:CAC42382.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE28136 WBGene00002324 locus:let-49 status:Confirmed UniProt:Q95Q17 protein_id:CAC42382.1| [wormORF-contam.fasta]
  • LEThal family member (let-49) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein Y54E5B.3b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE28136 WBGene00002324 locus:let-49 status:Confirmed UniProt:Q95Q17 protein_id:CAC42382.1 Mediator of RNA polymerase II transcription subunit 7 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 251 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: hermaphrodite genitalia development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    gastrulation with mouth forming first [IMPLink to PubMed article]
    positive regulation of transcription [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    Molecular Function: transcription coactivator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPGFGAQTV SPFPNPPEYA SAYTSDRINN GSAPPPPHPL TEFKVYGEEY RLEDDVIAPL  60
   61 KNAGVAELYK NKNNWKTEMK KLNRSAIVAF FDLVEILIRA PDHPMREEKM VDLHTIFINM 120
  121 HHLINEFRPV QARDSVRILQ ERQIEELSDI CKDFKKYLRD GREVVDDQFQ MIRGKLPAPP 180
  181 QPSELTRVKL QDGVLHMLQE TEASDDVEMK EEEGSEYSKK KARLELLSRE DGPPSVVHLL 240
  241 ARQFHDISLK K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] Pfam 15.086186 No description for PF05983.2 was found. No confident structure predictions are available.
    2 View Details [104..178] PSI-BLAST 21.69897 Structure of the mediator MED7/MED21 subcomplex
    3 View Details [179..251] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle