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Protein Overview: tlf-1

General Information:
Name(s) found: tlf-1 / CE27159 [WormBase]
Description(s) found:
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  • WBGene00006577 locus:tlf-1 status:Confirmed UniProt:G5EC52 protein_id:CAB03082.2 [WormBase]
  • gi|7329167|gb|AAF59926.1| TBP-like factor [Caenorhabditis elegans] [NCBI NR]
  • gi|17509361|ref|NP_492356.1| TBP-Like Factor family member (tlf-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|14530454|emb|CAB03082.2| C. elegans protein F39H11.2a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed TR:P90869 protein_id:CAB03082.2 [wormpep150.fasta]
  • 27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed TR:P90869 protein_id:CAB03082.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • TATA box binding protein-Like Factor, transcription initiation factor TFIID required to activate RNA polymerase II transcription of some specific genes during C. elegans embryogenesis (57.3 kD) (tlf-1) [Caenorhabditis elegans]gi|14530454|emb|CAB03082.2| [nrdb_11152004_Chlamydomonas]
  • locus:tlf-1 transcription factor TFIID like status:Confirmed TR:P90869 protein_id:CAB03082.2 [wormpep115.fasta.reversed]
  • CE27159 locus:tlf-1 transcription factor TFIID like status:Confirmed TR:P90869 protein_id:CAB03082.2 [wormpep80.hongbin]
  • CE27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed UniProt:P90869_CAEEL protein_id:CAB03082.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed UniProt:P90869_CAEEL protein_id:CAB03082.2| [wormORF-contam.fasta]
  • Hypothetical protein F39H11.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • TBP-like factor [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • TBP-Like Factor family member (tlf-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed UniProt:P90869 protein_id:CAB03082.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE27159 WBGene00006577 locus:tlf-1 transcription factor TFIID like status:Confirmed UniProt:G5EC52 protein_id:CAB03082.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE27159 WBGene00006577 locus:tlf-1 status:Confirmed UniProt:G5EC52 protein_id:CAB03082.2 [wormpep246-ecoli-contam.fasta]
  • Isoform of B2D6P4, TBP-Like Factor OS=Caenorhabditis elegans GN=tlf-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    transcription factor TFIID complex [IEALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    positive regulation of protein amino acid phosphorylation [IMPLink to PubMed article]
    gastrulation with mouth forming first [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed articleLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    RNA polymerase II transcription factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMGDHQMMG NQRTYVQKVM PAQAGGAVSQ NATYVQTAGI RTVHHDGNGQ QRIVQLPPGV  60
   61 RQIQQNGVGP AYVRQVPGGQ PMQVNFGHPG TIAGRNVAVG VQMRPVQGHN VQQGYQRQQV 120
  121 ANQIQQQNRA VFMAQNQQGQ QQISYAQAQH RQQQQNQQQH HQQPQHFNHP SQQNQMIMQH 180
  181 RQPQMHHNQQ HQMVQPQMTR HQMAQHHAQQ PHPQIYVPRD MNLAVPLREP SPEPIPVKIE 240
  241 VPDVPPEGTS AANEEPMPDD GDIDIQIRNV VCNYTLPLHI DLRKLAMNTH NVTYEREKGV 300
  301 MMKQKRSPGC YIKVYSSGKV YIVGCRSEAD CKRAARSIAR HVQRVMGKTK ERVSIRNYRV 360
  361 NNVLATCRLP FGIKIEEVAA KYPSESTYEP ELSVGLVWRS VTPKATLRIH TTGSITVTGA 420
  421 QSEADVLEVL SKIYPIVLEF RCLERAKGNV AAQKKRKRKA PVNRGPPIKR ERFDDSNYRN 480
  481 SGVINNQVYF SDEDEDLYDE LDLEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 8.221849 Sec24
    2 View Details [143..250] MSA 1.156996 View MSA. No confident structure predictions are available.
    3 View Details [251..505] PSI-BLAST 90.39794 TATA-box binding protein (TBP), C-terminal domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle