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Protein Overview: bre-1

General Information:
Name(s) found: bre-1 / CE23608 [WormBase]
Description(s) found:
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  • WBGene00000266 locus:bre-1 GDP-mannose 4,6 dehydratase 1 status:Confirmed UniProt:Q18801 protein_id:CAA92455.2 [WormBase]
  • sp|Q18801|GMD1_CAEEL Probable GDP-mannose 4,6 dehydratase 1 (GDP-D-mannose dehydratase) (GMD) [NCBI NR]
  • pir||T20182 hypothetical protein C53B4.7 - Caenorhabditis elegans [NCBI NR]
  • gi|5824413|emb|CAA92455.2| C. elegans protein C53B4.7c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|133901786|ref|NP_001076668.1| BT (Bacillus thuringiensis) toxin REsistant family member (bre-1) [Caenorhabditis elegans] [NCBI NR]
  • (Q18801) Probable GDP-mannose 4,6 dehydratase 1 (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) [Swiss-Prot]
  • [wormpep67.fasta]
  • hypothetical protein C53B4.7 - Caenorhabditis elegansgi|9087157|sp|Q18801|GMD1_CAEEL Probable GDP-mannose 4,6 dehydratase 1 (GDP-D-mannose dehydratase) (GMD) [nrdb_11152004_Chlamydomonas]
  • CE23608 WBGene00000266 locus:bre-1 status:Confirmed UniProt:Q18801 protein_id:CAA92455.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE23608 WBGene00000266 locus:bre-1 status:Confirmed UniProt:Q18801 protein_id:CAA92455.2| [wormORF-contam.fasta]
  • Hypothetical protein C53B4.7c [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE23608 WBGene00000266 locus:bre-1 status:Confirmed TR:Q067Y5 protein_id:CAA92455.2 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • Isoform c of GDP-mannose 4,6 dehydratase 1 OS=Caenorhabditis elegans GN=bre-1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • CE23608 WBGene00000266 locus:bre-1 status:Confirmed UniProt:Q18801 protein_id:CAA92455.2 GDP-mannose 4,6 dehydratase 1 [wormpep246-ecoli-contam.fasta]
  • Isoform of Q18801, Isoform c of GDP-mannose 4,6 dehydratase 1 OS=Caenorhabditis elegans GN=bre-1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 368 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: GDP-L-fucose biosynthetic process [IDALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    GDP-mannose metabolic process [IDALink to PubMed article][IEALink to PubMed article]
    nucleotide-sugar metabolic process [IEALink to PubMed article]
    galactose metabolic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    Molecular Function: coenzyme binding [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    UDP-glucose 4-epimerase activity [IEALink to PubMed article]
    dTDP-glucose 4,6-dehydratase activity [IEALink to PubMed article]
    GDP-mannose 4,6-dehydratase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHEVSTTPA AELAAFRARK VALITGISGQ DGSYLAELLL SKGYKVHGII RRSSSFNTAR  60
   61 IEHLYSNPIT HHGDSSFSLH YGDMTDSSCL IKLISTIEPT EVYHLAAQSH VKVSFDLPEY 120
  121 TAEVDAVGTL RLLDAIHACR LTEKVRFYQA STSELYGKVQ EIPQSEKTPF YPRSPYAVAK 180
  181 MYGYWIVVNY REAYNMFACN GILFNHESPR RGETFVTRKI TRSVAKISLG QQESIELGNL 240
  241 SALRDWGHAR EYVEAMWRIL QHDSPDDFVI ATGKQFSVRE FCNLAFAEIG EVLQWEGEGV 300
  301 EEVGKNKDGV IRVKVSPKYY RPTEVETLLG NAEKAKKTLG WEAKVTVPEL VKEMVASDII 360
  361 LMKSNPMA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..368] PSI-BLAST 78.69897 Crystal structure of human GDP-D-mannose 4,6-dehydratase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle