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Protein Overview: unc-11

General Information:
Name(s) found: unc-11 / CE23564 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00006751 locus:unc-11 Phosphatidylinositol-binding clathrin assembly protein unc-11 status:Partially_confirmed UniProt:Q9XZI6 protein_id:CCD66412.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: presynaptic membrane [IDALink to PubMed article]
    Biological Process: locomotion [IMPLink to PubMed article]
    synaptic vesicle endocytosis [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    post-embryonic development [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    Molecular Function: clathrin binding [ISSLink to PubMed article]
    phospholipid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTIEKALHQ PMPFTTGGQT ISDRLTAAKH SLAGSQLGKT ICKATTEEVM APKKKHLDYL  60
   61 LHCTNEPNVS IPSMANLLIE RTQNPNWTVV YKALITIHNI MCYGNERFSQ YLASCNTTFN 120
  121 LTAFVDKVGG AGGYDMSTHV RRYAKYIGEK INTYRMCAFD FCKVKRGRED GLLRTMHTDK 180
  181 LLKTIPILQN QIDALLEFSV TTSELNNGVI NCSFILLFRD LIRLFACYND GIINVLEKYF 240
  241 DMNKKQCRDA LDTYKSFLTR LDKVAEFLRV AESVGIDRGE IPDLTRAPAS LLEALEAHLI 300
  301 HLEGGKAPPP TQQHVAPHQF TTGFAFSQQP QPALGDAERQ RYIELEQERL RQFEDQKKSI 360
  361 NSANPFANDV ASAAPAPATS AAQPDLLDMF QSSAAPLLQC NRKLQMVSHQ AAPFGYPNAH 420
  421 PDDLARMTAQ MSLNQQGAPA GWNTTTSAVS NNPFGATSAP QPMYTAPMGM YQQPFGAQPM 480
  481 WNPAMAAYGQ QYGYGQPVPP QQQHQIQLVH AAMAAKNAAQ AQQAQAASAD PFGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304] PSI-BLAST 104.0 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    2 View Details [305..534] PSI-BLAST 6.154902 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  3.05300014576459 bayes_pls_golite062009
  • binding
    		•  2.13445840178249 bayes_pls_golite062009
  • protein binding
    		•  1.7891964555817 bayes_pls_golite062009
  • phospholipid binding
    		•  1.38798066582556 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.26458267960741 bayes_pls_golite062009
  • lipid binding
    		•  0.4499495998145 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.14699617064037 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle