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Protein Overview: dnj-27

General Information:
Name(s) found: dnj-27 / CE20265 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00001045 locus:dnj-27 status:Partially_confirmed UniProt:Q9XWE1 protein_id:CAA21734.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 788 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article]
    Biological Process: response to heat [IEALink to PubMed article]
    glycerol ether metabolic process [IEALink to PubMed article]
    cell redox homeostasis [IEALink to PubMed article]
    protein folding [IEALink to PubMed article]
    Molecular Function: heat shock protein binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein disulfide oxidoreductase activity [IEALink to PubMed article]
    electron carrier activity [IEALink to PubMed article]
    unfolded protein binding [IEALink to PubMed article]
    isomerase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAIVLLSVL ISCYLVIAED YYELLGVERD ADDRTIRKAF KKLAIKKHPD RNTDDPNAHD  60
   61 EFVKINKAYE VLKDENLRKK YDQFGEKGLE DGFQGGNNYQ SWQFYNDNFG IYDDDQEIVT 120
  121 LNRADFQRMV SDSNEIWFIN FYSTYCSHCH QLAPTWRKFA REIEGTIRVG AVNCAEDPQL 180
  181 CQSQRVNAYP SLVFYPTGEF YQGHRDVELM VDFAIQRLKS EVLHLNSENW KALSEDWEPY 240
  241 NRLPWVVDMC GGDHIDCLSS TTRRKLSSML DGLANVATID CNAEEALCSK FNPITSGVMW 300
  301 FPARKLVKKS QINIESMDAQ EISKSVIQYL DELEDISVES LQRLLEGNDP DEPIAVWMLA 360
  361 NDAQSTERKD FRRLPALVTT QIFKFDCSKS SEICDELLDK TKLPQFMVFK TTGGYEIDYA 420
  421 GSKDFHAAST FIREASKSHI HVLNRDSYEY AISGGEFYII DYFAPWCPPC MKLLGEYRRF 480
  481 HTATSEDSML HTVAIGSLDC VKYKDLCQQA GVQSYPTSIV YTPDGKTHKM VGYHNVDYIL 540
  541 EFLDNSLNPS VMEMSPEQFE ELVMNRKDEE TWLVDFFAPW CGPCQQLAPE LQKAARQIAA 600
  601 FDENAHVASI DCQKYAQFCT NTQINSYPTV RMYPAKKTKQ PRRSPFYDYP NHMWRNSDSI 660
  661 QRWVYNFLPT EVVSLGNDFH TTVLDSSEPW IVDFFAPWCG HCIQFAPIYD QIAKELAGKV 720
  721 NFAKIDCDQW PGVCQGAQVR AYPTIRLYTG KTGWSRQGDQ GIGIGTQHKE QFIQIVRQQL 780
  781 KLDEHDEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] PSI-BLAST 17.69897 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    2 View Details [125..548] PSI-BLAST 48.69897 Crystal Structure of Yeast Protein Disulfide Isomerase
    3 View Details [549..666] PSI-BLAST 10.30103 PROTEIN DISULFIDE OXIDOREDUCTASE FROM ARCHAEON PYROCOCCUS FURIOSUS
    4 View Details [667..788] PSI-BLAST 30.0 No description for 2h73A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • chaperone binding
    		•  1.61155546076854 bayes_pls_golite062009
  • binding
    		•  1.60921541945619 bayes_pls_golite062009
  • protein binding
    		•  0.912937133925792 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein disulfide isomerase activity
    		•  4.54149370439152 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  4.54149370439152 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  4.32416700334664 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.07184913651636 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.858243161645005 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.44918717550973 bayes_pls_golite062009
  • binding
    		•  0.235855919597681 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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