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Protein Overview: gmd-2

General Information:
Name(s) found: gmd-2 / CE16133 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00010166 locus:gmd-2 GDP-mannose 4,6 dehydratase 2 status:Partially_confirmed UniProt:O45583 protein_id:CAB04494.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 382 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    locomotion [IMPLink to PubMed article]
    GDP-L-fucose biosynthetic process [IDALink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    GDP-mannose metabolic process [IDALink to PubMed article][IEALink to PubMed article]
    nucleotide-sugar metabolic process [IEALink to PubMed article]
    oviposition [IMPLink to PubMed article]
    galactose metabolic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: coenzyme binding [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    UDP-glucose 4-epimerase activity [IEALink to PubMed article]
    dTDP-glucose 4,6-dehydratase activity [IEALink to PubMed article]
    GDP-mannose 4,6-dehydratase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEARNAEGLE SCIEKIQEVK LSSFAELKAF RERKVALITG ITGQDGSYLA ELLLSKGYKV  60
   61 HGIIRRSSSF NTARIEHLYG NPVTHNGSAS FSLHYGDMTD SSCLIKLIST IEPTEIYHLA 120
  121 AQSHVKVSFD LPEYTAEVDA VGTLRLLDAI HACRLTEKVR FYQASTSELY GKVQEIPQSE 180
  181 LTPFYPRSPY AVAKMYGYWI VVNYREAYKM FACNGILFNH ESPRRGETFV TRKITRSVAK 240
  241 ISLRQQEHIE LGNLSALRDW GHAKEYVEAM WRILQQDTPD DFVIATGKQF SVREFCNLAF 300
  301 AEIGEQLVWE GEGVDEVGKN QDGVVRVKVS PKYYRPTEVE TLLGNPAKAR KTLGWEPKIT 360
  361 VPELVKEMVA SDIALMEADP MA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..382] PSI-BLAST 78.09691 Crystal structure of human GDP-D-mannose 4,6-dehydratase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • binding
    		•  0.195230307786433 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle