Protein Overview: top-1

General Information:
Name(s) found:	top-1 / CE12282 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00006595 locus:top-1 DNA topoisomerase 1 status:Confirmed UniProt:O17966 protein_id:CAB07640.1 [WormBase] pir\|\|T23648 hypothetical protein M01E5.5a - Caenorhabditis elegans [NCBI NR] gi\|74957937\|sp\|O17966.1\|TOP1_CAEEL RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase I; Short=topoI [NCBI NR] gi\|3878632\|emb\|CAB07640.1\| C. elegans protein M01E5.5a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17508321\|ref\|NP_493337.1\| TOPoisomerase family member (top-1) [Caenorhabditis elegans] [NCBI NR] DNA topoisomerase 1 OS=Caenorhabditis elegans GN=top-1 PE=2 SV=1 [Swiss-Prot] [wormpep67.fasta] CE12282 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed TR:O17966 protein_id:CAB07640.1 [wormpep150.fasta] 12282 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed TR:O17966 protein_id:CAB07640.1 [wormpep130-phg-ecoli-orf-rand.fasta] eukaryotic DNA topoisomerase I., TOPoisomerase (94.0 kD) (top-1) [Caenorhabditis elegans]gi\|3878632\|emb\|CAB07640.1\| Hypothetical protein M01E5.5a [Caenorhabditis elegans]gi\|7505886\|pir\|\|T23648 hypothetical protein M01E5.5a - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas] locus:top-1 DNA topoisomerase I status:Confirmed TR:O17966 protein_id:CAB07640.1 [wormpep115.fasta.reversed] CE12282 DNA topoisomerase I status:Confirmed TR:O17966 protein_id:CAB07640.1 [wormpep80.hongbin] CE12282 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:TOP1_CAEEL protein_id:CAB07640.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE12282 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:O17966_CAEEL protein_id:CAB07640.1\| [wormORF-contam.fasta] TOPoisomerase family member (top-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein M01E5.5a [Caenorhabditis elegans] [nr-271106-contam.fasta] CE12282 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:O17966 protein_id:CAB07640.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE12282 WBGene00006595 locus:top-1 status:Confirmed UniProt:O17966 protein_id:CAB07640.1 DNA topoisomerase 1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	806 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] spindle pole centrosome [IDA] chromosome [IEA] nucleolus [IDA]
Biological Process:	molting cycle, protein-based cuticle [IMP] positive regulation of growth rate [IMP] embryonic development ending in birth or egg hatching [IMP] chromosome segregation [IMP] gamete generation [IMP] DNA topological change [IEA] DNA unwinding involved in replication [IEA] positive regulation of multicellular organism growth [IMP] growth [IMP] reproduction [IMP] oocyte construction [IMP] locomotory behavior [IMP] gonad development [IMP] morphogenesis of an epithelium [IMP] nematode larval development [IMP]
Molecular Function:	DNA binding [IEA] DNA topoisomerase type I activity [IDA][IEA] DNA topoisomerase (ATP-hydrolyzing) activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVVSNHHSN GNGNSTVYDT NGNDEIKKEV KDEPMASDSE VPFGELMKRD KKEKKQKKRK  60
   61 AESGSDEDDY KPEKRKSSAK NGKKKDVGSD SEDDYKPEKK KSKKNNKKKA QESSEDDDEE 120
  121 SEGDVSEEDV KPQIHSDDEL EEEDEAPTTD DEEEQKRKEK ERRKKEKREK KERKEKKRLE 180
  181 KENRKIKEED DEDSDDEDDE KAKKKKRKSK GAEKSKPSTS KKDAGGKKEP PKKKVKKEED 240
  241 IEDIWEWWKE EKKPAGVKWN SLQHCGPLFA PPYIPLPSHV HFKYGGEKMK LTLETEEIAQ 300
  301 FYAGVLDHEY STKEAFNKNF MKDWRKVMTV EERERIHDLK KCDFRAIDAY QKEQREIRKA 360
  361 MTKEEKLKIK EEKEAEVKIY GIAIIDGHRQ KVANFRIEPP GVFRGRGGHP KMGLIKKRIM 420
  421 PEDVIINCGK DTEIPKPPPG HKWKEVRHDN TVTWLCSWTE SVLGQNKYIM LNPSSKIKGE 480
  481 KDFEKYETAR RLKKKIGGIR ERYTDDFKSK EMRVRQRATA LYFIDKLALR AGNEKDVDEA 540
  541 ADTVGCCSLR VEHIKLFDSA KLNEDDKKEK EFVVEFDFLG KDSIRYFNRV SVEKRVYKNL 600
  601 KIFMEGKAPS DDLFDRLDTA TLNDHLRSLM DGLTVKVFRT YNASITLQEQ LIKLTNPKDN 660
  661 VAAKILSYNR ANRQVAILCN HQRAVSKGFD ESMQKLEQKI KDKKKEVKEA EAALKSARGA 720
  721 EKEKAQKKYD RLKEQLKKLK ISRTDKDENK QIALGTSKLN YIDPRITVAW CKKFEVPLEK 780
  781 VFTKTHREKF RWAIDMTNSS DEEYVF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: top-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: