Protein Overview: top-2

General Information:
Name(s) found:	top-2 / CE06184 [WormBase]
Description(s) found: Found 22 descriptions. SHOW ALL	WBGene00010785 locus:top-2 Probable DNA topoisomerase 2 status:Partially_confirmed UniProt:Q23670 protein_id:CAA88867.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	1520 amino acids
Gene Ontology:
Cellular Component:	chromosome [IEA]
Biological Process:	embryonic cleavage [IMP] embryonic development ending in birth or egg hatching [IMP ] cytokinesis [IMP] DNA topological change [IEA] DNA metabolic process [IEA] DNA unwinding involved in replication [IEA] reproduction [IMP]
Molecular Function:	DNA binding [IEA] ATP binding [IEA] DNA topoisomerase (ATP-hydrolyzing) activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSDSEFSI EDSPKKKTAP KKEKASPKKK KDDANESMVM TEEDRNVFTS IDKKGGGSKQ  60
   61 MAIEDIYQKK SQLEHILLRP DTYIGSVEHT EKTPMWVYNM EESKLEQRDI SYVPGLYKIY 120
  121 DEILVNAADN KQRDPKMNTI KITINKEKNE ISVYNNGKGI PVTQHKVEKV YVPELIFGTL 180
  181 LTSSNYNDDE KKVTGGRNGY GAKLCNIFST KFTLETSSRD YKSAFKQTWI KNMTRDEEPK 240
  241 IVKSTDEDFT KITFSPDLAK FKMKELDDDI CHLMARRAYD VAGSSKGVAV FLNGKRIPIK 300
  301 GFEDYVQMYT SQFNNEGEPL KIAYEQVGDR WQVALALSEK GFQQVSFVNS IATTKGGRHV 360
  361 DYVADQMVAK FIDSIKRKLT KTSMNIKPFQ IKNHMWVFVN CLIENPTFDS QTKETMTLQQ 420
  421 KQFGSTCVLS EKFSKAASSV GITDAVMSWV RFKQMDDLNK KCSKTKTSKL KGIPKLEDAN 480
  481 DAGTKNSQQC TLILTEGDSA KTLAVSGLSV VGRDKYGVFP LRGKLLNVRE GNMKQIADNA 540
  541 EVNAMIKILG LQYKKKYETE DDFKTLRYGK LMVMADQDQD GSHIKGLVIN FIHHFWPSLI 600
  601 QRNFVEEFIT PIVKATKGKE EVSFYSLPEY SEWRMNTDNW KSYKIKYYKG LGTSTSKEAK 660
  661 EYFLDMVRHR IRFKYNGADD DNAVDMAFSK KKIEERKDWL SKWMREKKDR KQQGLAEEYL 720
  721 YNKDTRFVTF KDFVNRELVL FSNLDNERSI PCLVDGFKPG QRKVLFACFK RADKREVKVA 780
  781 QLAGAVAEIS AYHHGEQSLM GTIVNLAQDY VGSNNINLLL PIGQFGTRLQ GGKDSASARY 840
  841 IFTQLSPVTR TLFPAHDDNV LRFLYEENQR IEPEWYCPII PMVLVNGAQG IGTGWSTNIP 900
  901 NYNPRELVKN IKRLIAGEPQ KALAPWYKNF RGKIIQIDPS RFACYGEVAV LDDNTIEITE 960
  961 LPIKQWTQDY KEKVLEGLME SSDKKSPVIV DYKEYHTDTT VKFVVKLSPG KLRELERGQD1020
 1021 LHQVFKLQAV INTTCMVLFD AAGCLRTYTS PEAITQEFYD SRQEKYVQRK EYLLGVLQAQ1080
 1081 SKRLTNQARF ILAKINNEIV LENKKKAAIV DVLIKMKFDA DPVKKWKEEQ KLKELRESGE1140
 1141 IELDEDDLAA VAVEEDEAIS SAAKAVETKL SDYDYLVGMA LIKLSEEEKN KLIKESEEKM1200
 1201 AEVRVIEKKT WQDLWHEDLD NFVSELDKQE AREKADQDAS IKNAAKKLAA DAKTGRGPKK1260
 1261 NVCTEVLPSK DGQRIEPMLD AATKAKYEKM SQPKKERVKK EPKEPKEPKK VKKEGQDIKK1320
 1321 FMSPAAPKTA KKEKSDGFNS DMSEESDVEF DEGIDFDSDD DGVEREDVVS KPKPRTGKGA1380
 1381 AKAEVIDLSD DDEVPAKKPA PAKKAAPKKK KSEFSDLSGG DSDEEAEKKP STSKKPSPKK1440
 1441 AAPKTAEPKS KAVTDFFGAS KKNGKKAAGS DDEDDESFVV APREKSGRAR KAPPTYDVDS1500
 1501 GSDSDQPKKK RGRVVDSDSD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: top-2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: