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Protein Overview: nhx-4

General Information:
Name(s) found: nhx-4 / CE02644 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00003732 locus:nhx-4 Sodium\/hydrogen exchanger status:Confirmed UniProt:G5ECB7 protein_id:CCD64772.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 684 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: sodium ion transport [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of pH [IEALink to PubMed article]
    Molecular Function: solute:hydrogen antiporter activity [IEALink to PubMed article]
    sodium:hydrogen antiporter activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAEGEWVQS APPEEIEEAK HLLDPVHVDF EHTHKPLAFV FLIILVTLAK PTLHWPVLRK  60
   61 LPESVVLMLY GVLMATAVKA LMRIDPGQLD TFMFFMILLP AIVNDAGLSM QKKEFTIALP 120
  121 KILLFAVVGT VVHALLLAAT MYGIEPIFSF KPGFLHLFVF ATLISAVDPV SVLSTFAELD 180
  181 VKKSLFILIF GESLCNDAVT IVLYRTSINV IKTSDASDEM LTITSVVGSC VVQFMIVCGF 240
  241 GLLCGAVVGF AGVFIMKNMV GHQMNQPIFQ LFCPYLAYLL AETGHYSGIL ASILCAAIMS 300
  301 YYMAANMCVE MEFAAFTFSK TGSSLSESCI FFYLGVSLVS YNHEFDFYFI AVTVFCCTLY 360
  361 RFLVTCTLSA FYNLFASEKN RIPFTDQLVV THAGIRGAVC FGLVQIIDER IIPAKPYFVT 420
  421 TTLAMIFVTS ILQGCTIKFV MKCLKIPGDD GTKQKDPKAL RWLTHLNDKY IKKFLVSENT 480
  481 YLPTDETFRN LGLPKAVSTA LRIGERSHTD LQRHGEVSHT PAPSVGRPTI APFDFGNMEE 540
  541 ENNRLPSTGR RTPVARSQTR YSRHFIYAIP NETDNYLTCP VSASKRPPFD PSQVYQHQNT 600
  601 ISNPGDDRAR CYNRRHNSMS GADEMELKQL NQTVQKKLSR TITSGTKQFV VNPDEAIREE 660
  661 SPATIPKKRA TFEDDEISKI DESE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..448] FFAS03 1.14 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
    2 View Details [449..684] FFAS03 1.49 C-terminal domain of PLC-beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  3.68358946453037 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.88029274676926 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61490029662518 bayes_pls_golite062009
  • transporter activity
    		•  2.56678559513061 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.04202790807134 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87997658689447 bayes_pls_golite062009
  • binding
    		•  0.829924243430409 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.00204662663751018 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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