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Protein Overview: nuo-1

General Information:
Name(s) found: nuo-1 / CE02132 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00003831 locus:nuo-1 status:Confirmed UniProt:Q17880 protein_id:CAA90435.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 479 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDA]
    Biological Process: electron transport [IEALink to PubMed article]
    mitochondrial electron transport, NADH to ubiquinone [IEALink to PubMed article][IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: FMN binding [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    NADH dehydrogenase (ubiquinone) activity [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]
    oxidoreductase activity, acting on NADH or NADPH [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASAAVSLGA RLIGQNVPKV AVRGVVTSAQ NANAQVKQEK TSFGNLKDSD RIFTNLYGRH  60
   61 DYRLKGAMAR GDWHKTKEII LKGSDWILGE LKTSGLRGRG GAGFPSGMKW GFMNKPFDGR 120
  121 PKYLVVNADE GEPGTCKDRE IMRHDPHKLI EGCLIGGVAM GARAAYIYIR GEFYNEACIL 180
  181 QEAINEAYKA GYLGKDCLGT GYNFDVFVHR GAGAYICGEE TALIESLEGK QGKPRLKPPF 240
  241 PADIGLFGCP TTVTNVETVA VAPTICRRGG DWFASFGRER NRGTKLFCIS GQVNNPCTVE 300
  301 EEMSVPLKDL IERHCGGVIG GWDNLLAIIP GGSSVPLMPK NVCDTVLMDF DALVAAQSGL 360
  361 GTAAVIVMNK QTDIVKCIAR LSLFYKHESC GQCTPCREGC NWLNKMMWRF VDGKAKPSEI 420
  421 DMMWELSKQI EGHTICALGD AAAWPVQGLI RHFRPELERR MAEFHKQVLA EQGAKQISQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..479] PSI-BLAST 150.0 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  13.4136491947011 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  12.443012098477 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  12.1743193111446 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  11.5132141901667 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  10.8948060301507 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.75377893144873 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  3.21486196088149 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  2.15499718507114 bayes_pls_golite062009
  • electron carrier activity
    		•  1.50427278540084 bayes_pls_golite062009
  • catalytic activity
    		•  1.46362311772849 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • metal cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • binding
    		•  1.25265721111105 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor
    		•  0.530794334701446 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.471058486160512 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  0.281674499766589 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  0.281674499766589 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle