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Protein Overview: lsd1

General Information:
Name(s) found: lsd1 / SPBC146.09c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • histone demethylase SWIRM1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1000 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Lsd1/2 complex [IDALink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    Biological Process: chromatin remodeling [ISSLink to PubMed article]
    cellular response to heat [IEPLink to PubMed article]
    positive regulation of transcription, DNA-dependent [IMPLink to PubMed article]
    regulation of meiosis [IMPLink to PubMed article]
    histone H3-K9 demethylation [IMPLink to PubMed article]
    antisense RNA transcription [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    histone demethylase activity (H3-monomethyl-K4 specific) [NAS]
    nucleosome binding [IDALink to PubMed article]
    histone demethylase activity (H3-K9 specific) [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDLSSKDAL SDVLKDTHAQ SSDPSLWAIF GHQSSDNVHE GGNESVSVEQ EIFDLSQLSE  60
   61 RPVSETVSKA SIPTNINGLS QVKPSALEKS QEVLSLQKLP IKGRRPAGRR GRPALNTSNS 120
  121 LERNGTRYVS AEAPISVKSS IPAIPRVTFE RLCYESAIAS NLPPNALSPL EAEMLSEILE 180
  181 NPTWLSLYLS IRNGICYLWH RNPTLYVSFN EALGIVREKK AFPLASLAFE FLSRNGHINY 240
  241 GCIYIISSLK LDESLSQKTV AIIGAGMAGI SCARQLTNLF AQYEQDFLSR GEKPPRIVIY 300
  301 EASERLGGHI YTHMVPLSDN EVSEKSSLAT TVNATNECMV NLLTDSLIGM PTLDSDPLYI 360
  361 ISSQQLSLDA VHTRNREFIL HDIENGRIDT EHVQRIFRLF DALLFYFNAS ASKQPLHSLI 420
  421 TPPEQEFIQK LDQIGWYISI EAFPLQIKDT LSEFLGNSAN TLTSLLHLTV LDLKIFEWFK 480
  481 EYLSQSLSVS LENVYPGSIP NLNLLLGENV ASYSFKHGMA DMLNSLASTP SPLPILFDQC 540
  541 VHTVKLEDNT VNLSFVNETT VSVDKVVICI PMDKLNTHLI TFEPPLEEKK LKAIDRCHFT 600
  601 NVKKVILIFK TQFWEPNISI FGSLPQDSGR NFIFNDCTRF YEHPTLSVFV KVEGIDFMKD 660
  661 DDIVNGIVSQ LKKVYKPKSE AINPIRTIIS NWENNSYTNH SSYQISNLFL EEDYAILSEP 720
  721 IDNTVFFASE AISQKNSGSI RGAFDSGILA ARDVLASLIG NVVLPNTLVI EENLEQPRKT 780
  781 YGTKRNAQQA LGKEGERENK EKRISYHTEY LRLRQKRLDK EQQECDLLIA ELLGPSPVPP 840
  841 SRPSANPYLL YQKTQWHVCK TLADQDKQRV TGDPEARATK NEIRAKLGKT WRALDSLGKQ 900
  901 PWVDEINARR ANYSTRLEEY QRQINSYNVR VAQIKSEHQR RCESQPIPED EAKLKLLAEQ 960
  961 EDEHLHPEKE GMSVENSDDD YHDDLDYEDS ISEVFPDNFS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] MSA 1.065995 View MSA. No confident structure predictions are available.
    2 View Details [107..235] Pfam 26.161151 No description for PF04433.4 was found. No confident structure predictions are available.
    3 View Details [236..785] PSI-BLAST 74.0 The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A
    4 View Details [786..1000] PSI-BLAST 4.045757 Heavy meromyosin subfragment


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle