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Protein Overview: top3

General Information:
Name(s) found: top3 / SPBC16G5.12c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • DNA topoisomerase III [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    RecQ helicase-Topo III complex [TASLink to PubMed article]
    Biological Process: nucleolus organization [IMPLink to PubMed article]
    DNA-dependent DNA replication [IMPLink to PubMed article]
    nuclear division [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    resolution of meiotic recombination intermediates [TASLink to PubMed article]
    replication fork processing [NAS]
    DNA topological change [IEA]
    DNA metabolic process [IGILink to PubMed article]
    DNA unwinding involved in replication [IEA]
    maintenance of rDNA [IMPLink to PubMed article]
    negative regulation of DNA recombination [TASLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    DNA topoisomerase type I activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVLCVAEKN SIAKSVASIL GGGHVRRRDT RSKYVKNYDF SFNFGGNVGS SDVTMTSVSG  60
   61 HLTEASFPSE YSSWSSVPQD VLFDAQIITS VSKNAEVLAD NIKKEARNAQ YLYIWTDCDR 120
  121 EGEHIGVEIS NVARASNPSI QVIRADFNNL ERSHIISAAK RPRDVSKNAA DAVDARIELD 180
  181 FRLGAIFTRL QTIQLQKSFD ILQNKIISYG PCQFPTLGFV VDRWQRVEDF VPETYWHLRF 240
  241 VDKRQGKTIQ FNWERAKVFD RLTTMIILEN CLECKTAKVV NITQKPKTKY KPLPLSTVEL 300
  301 TKLGPKHLRI SAKKTLELAE NLYTNGFVSY PRTETDQFDS SMNLHAIIQK LTGAQEWDSY 360
  361 AEGLLAGDYR PPRKGKHNDR AHPPIHPVQM VHRSALPSQD HWKVYELITR RFLACCSDNA 420
  421 KGAETLVQVK MEEELFSKKG LLVTEKNYLE VYPYEKWESS DQLPEYRLHE EFQPHILDMM 480
  481 DSSTSSPSYI TEPELIALMD ANGIGTDATM AEHIEKVQER EYVIKRKKRG QGVTEFVPSS 540
  541 LGVALAKGYD EIGLEWSLTK PFLRKEMEVQ LKNIENGQLN RNVLVHMILT QFRDVFHLTK 600
  601 QRFDCLKNSC RVYLMSHNEP QT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..622] PSI-BLAST 179.0 DNA topoisomerase I, 67K N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  10.2798831210729 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  8.04585827786358 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • DNA binding
    		•  5.20730175008144 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.95671919332271 bayes_pls_golite062009
  • binding
    		•  4.3089127577748 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
  • protein binding
    		•  0.377429709958808 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle