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Protein Overview: erg6

General Information:
Name(s) found: erg6 / SPBC16E9.05 [Sanger Pombe]
Description(s) found:
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  • pir||T39579 sterol methyltransferase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|6166151|sp|O14321.1|ERG6_SCHPO RecName: Full=Sterol 24-C-methyltransferase; AltName: Full=Delta(24)-sterol C-methyltransferase [NCBI NR]
  • gi|2467267|emb|CAB16897.1| delta-sterol C-methyltransferase Erg6 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112579|ref|NP_595787.1| delta-sterol C-methyltransferase (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • delta-sterol C-methyltransferase [Sanger Pombe]
  • Sterol 24-C-methyltransferase OS=Schizosaccharomyces pombe GN=SPBC16E9.05 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE DELTA-STEROL C-METHYLTRANSFERASE: O14321;P78782; [pompepVF.fasta]
  • Probable sterol 24-C-methyltransferase (EC 2.1.1.41) (Delta(24)-sterol C-methyltransferase) [pompep4896]
  • |||putative delta-sterol c-methyltransferase [pompepnew.fasta]
  • |||delta-sterol c-methyltransferase (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative delta-sterol c-methyltransferase [Schizosaccharomyces pombe]gi|2467267|emb|CAB16897.1| SPBC16E9.05 [Schizosaccharomyces pombe]gi|7493435|pir||T39579 sterol methyltransferase - fission yeast (Schizosaccharomyces pombe)gi|6166151|sp|O14321|ERG6 [nrdb_11152004_Chlamydomonas]
  • |erg6||delta-sterol C-methyltransferase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (O14321) Probable sterol 24-C-methyltransferase (EC 2.1.1.41) (Delta(24)-sterol C-methyltransferase) [pompep4896_normal_reversed]
  • |erg6||delta-sterol C-methyltransferase Erg6 |Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Sterol 24-C-methyltransferase (Delta(24)-sterol C-methyltransferase) [nr-271106-contam.fasta]
  • hypothetical protein SPBC16E9.05 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC16E9.05 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • |erg6||sterol 24-C-methyltransferase Erg6|Schizosaccharomyces pombe|chr 2|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Sterol 24-C-methyltransferase erg6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg6 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 378 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    endoplasmic reticulum [ISSLink to PubMed article]
    Biological Process: establishment of protein localization in plasma membrane [IMPLink to PubMed article]
    protein insertion into membrane raft [IMPLink to PubMed article]
    ergosterol biosynthetic process [IMPLink to PubMed article][ISSLink to PubMed article]
    [NOT]endocytosis [IMPLink to PubMed article]
    [NOT]protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: sterol 24-C-methyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTALLPPN TDQVLSRRLH GKAAEKKTGL AAIASKDVDE QSRKLQEYFE FWDRNHENES  60
   61 EEDRARRIDG YKSVVNSYYD LATDLYEYGW SQSFHFSRFY KGEAFAQSIA RHEHYLAYRM 120
  121 GIKPGSRVLD VGCGVGGPAR EITEFTGCNL VGLNNNDYQI SRCNNYAVKR NLDKKQVFVK 180
  181 GDFMHMPFED NTFDYVYAIE ATVHAPSLEG VYGEIFRVLK PGGVFGVYEW VMSDDYDSSI 240
  241 PKHREIAYNI EVGDGIPQMV RKCDAVEAIK KVGFNLLEED DLTDHDNPDL PWYYPLTGDI 300
  301 TKCQNIWDVF TVFRTSRLGK LVTRYSVQFL EKIGVAAKGT SKVGDTLAIA QKGLIEGGET 360
  361 HLFTPMFLMI AKKPETDA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] PSI-BLAST 15.154902 Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase
    2 View Details [80..378] PSI-BLAST 33.522879 CmaA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • transferase activity
    		•  1.07321114919891 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.644010137949015 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.635463629299812 bayes_pls_golite062009
  • binding
    		•  0.422181371325275 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.181420092548185 bayes_pls_golite062009
  • DNA binding
    		•  0.00720144044916005 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle