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Protein Overview: MKP-4-PB, FBpp03...

General Information:
Name(s) found: FBpp0304757 [FlyBase]
MKP-4-PB / FBpp0074510 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=X:join(19517243..19517387,19517450..19517581,19517648..19517747,19517813..19518495,19518561..19518664); ID=FBpp0304757; name=MKP-4-PC; parent=FBgn0031044,FBtr0332481; dbxref=FlyBase:FBpp0304757,FlyBase_Annotation_IDs:CG14211-PC,REFSEQ:NP_001259717,GB_protein:AGB95557; MD5=0b3d0da95475d962e19f63759323c9c9; length=387; release=r5.56; species=Dmel; [FlyBase]
  • The gene MAPK Phosphatase 4 is referred to in FlyBase by the symbol Dmel\MKP-4 (CG14211, FBgn0031044). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19517147..19519762. It has the cytological map location 18D7-18D8. There is experimental evidence that it has the molecular function</span>: phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of JUN kinase activity. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 387 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: negative regulation of JUN kinase activity [IMP]
    protein amino acid dephosphorylation [IEA][NAS]
    Molecular Function: protein tyrosine phosphatase activity [IEA]
    phosphatase activity [IDA]
    protein tyrosine/serine/threonine phosphatase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQSQSQRQA WPSSSAGGGK AQDSGVLTRE DFDGGPVSID EVDTGLFLGN LTAATHMETL  60
   61 RSFKITHILT LDSVPLPQHI LEASFLTTKY IQIADMPRED ILQHLEGCVD FISSALAQQG 120
  121 NVLVHCYFGV SRSSSTVIAY MMKRHNLDFL PAYELVKAKR RFVQPNAGFV SQLKLFRRMG 180
  181 CKIDPNCQRY KIHRLRLAGE QMRKAKILPQ SFHSVVRPDP DITRENPEPI VFRCRRCRRV 240
  241 LASKSHVLEH KPRDRPPQEV VPKEKEEVAA AKLPAQSHDQ AENHHGARML EQLSERIRQS 300
  301 SLGSPGHEST PNYCRSILFV EPIAWMHRIM LNTQGRLYCP KCEQKLGNFS WINACKCPCG 360
  361 ETMTPAFYLI PSKVELSKAV QNVQTTV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] PSI-BLAST 36.221849 No description for 2g6zA was found.
    2 View Details [252..387] FFAS03 1.09 No description for 2i13A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle