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Protein Overview: wupA-PG

General Information:
Name(s) found: wupA-PG / FBpp0074298 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene wings up A is referred to in FlyBase by the symbol Dmel\wupA (CG7178, FBgn0004028). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17999586..18010855. It has the cytological map location 16F7. It is reported to have molecular function</span>: tropomyosin binding; actin binding. There is experimental evidence that it is involved in the biological process</span>: heart development; myofibril assembly; skeletal muscle tissue development; nervous system development; muscle organ development; nuclear division; muscle homeostasis; sarcomere organization; cardiac muscle tissue development. 29 alleles are reported. The phenotypes of these alleles are annotated with 34 unique terms, many of which group under: adult segment; adult mesothoracic segment; indirect flight muscle; cytoplasmic part; adult somatic muscle; organ system; contractile fiber part; sarcomere; nervous system; adult visceral muscle; blastoderm embryo; embryonic nervous system; multi-cell-component structure; adult circulatory system. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    troponin complex [NAS]
    Biological Process: muscle organ development [IMP][NAS]
    myofibril assembly [IMP]
    heart development [IMP]
    muscle cell homeostasis [IMP]
    skeletal muscle tissue development [IMP]
    nuclear division [IMP]
    nervous system development [IMP][NAS]
    sarcomere organization [IMP]
    cardiac muscle tissue development [IMP]
    Molecular Function: actin binding [NAS]
    tropomyosin binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEKKAAA PAAAPAAAAK PAAPAAAPAA NGKAAPAANG KAAPAAAAAP AGPPKDPNDP  60
   61 KVKAEEAKKA KQAEIERKRA EVRKRMEEAS KAKKAKKGFM TPERKKKLRL LLRKKAAEEL 120
  121 KKEQERKAAE RRRIIEERCG SPRNLSDASE GELQEICEEY YERMYICEGQ KWDLEYEVRK 180
  181 KDWEINDLNA QVNDLRGKFV KPALKKVSKY ENKFAKLQKK AAEFNFRNQL KVVKKKEFTL 240
  241 EEEEKEKKPD WSKGKPGDAK VKEEVEAEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..269] PSI-BLAST 9.39794 Heavy meromyosin subfragment


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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