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Protein Overview: disco-PA, disco-PB

General Information:
Name(s) found: disco-PB / FBpp0099796 [FlyBase]
disco-PA / FBpp0074028 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene disconnected is referred to in FlyBase by the symbol Dmel\disco (CG9908, FBgn0000459). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16104631..16110767. It has the cytological map location 14B3. There is experimental evidence that it has the molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: brain development; eclosion rhythm; locomotor rhythm; positive regulation of transcription from RNA polymerase II promoter. 25 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: nervous system; peripheral nervous system; adult segment; external compound sense organ; organ system; multi-cell-component structure; organ system subdivision; cuticle; embryonic nervous system; cephalopharyngeal skeleton. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene disconnected is referred to in FlyBase by the symbol Dmel\disco (CG9908, FBgn0000459). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16104631..16110767. It has the cytological map location 14B3. There is experimental evidence that it has the molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: brain development; eclosion rhythm; locomotor rhythm; positive regulation of transcription from RNA polymerase II promoter. 25 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: nervous system; peripheral nervous system; adult segment; external compound sense organ; organ system; multi-cell-component structure; organ system subdivision; cuticle; embryonic nervous system; cephalopharyngeal skeleton. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 568 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: eclosion rhythm [IMP]
    locomotor rhythm [IMP]
    photoreceptor cell maintenance [NAS]
    brain development [IMP][NAS]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    circadian rhythm [NAS]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [ISS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHIMNPFMS PAYLLGHGPH SHQHVHSHLP SHPQPNAASP ASSPGGSSGS GSGSAAGSGT  60
   61 GSGSSLKPRR WGSPPINLAG QFINPATGKK RVQCSICFKT FCDKGALKIH FSAVHLREMH 120
  121 KCTVEGCNMV FSSRRSRNRH SANPNPKLHS PHIRRKISPH DGRTAQQFPV FSPGTAAAAA 180
  181 AVAGRLPVAF PGLLPPPPPH HGHHPYVMFG GQAGLHGLGL LSTGCQDPDS GSVDNEQDAD 240
  241 PEDDNDFVYV DMQANSSSPA ASSEDQEEHE RDNEQDEEMH CSLSLASSSS IAADEERAAD 300
  301 QPLDFSLHKR RKSEQDREQE QEQEQERERE AEKEQEQDVE SDKEHEPEQE HELEREKRSP 360
  361 SDAFSMDQLL GKRKRHDSTA SSSACSTAAA SSASSSSASA SANPPQTSIK MDLDPDSDSA 420
  421 YMTSRRQMLP LPVLDLEEHH HLRLLQTQMF AAAAAAAATS QAPPTAFLPA GSPVDLAKDS 480
  481 PPMWSLLSEM YRSMLLKTQH QQYNHHHQLQ QQHQQEQHHH LTLSHHHQEQ HHHLGHHHMG 540
  541 HHHHHHHQHH QQQPQQQSPA ATNAPISV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 52.522879 No description for 2i13A was found.
    2 View Details [186..392] PSI-BLAST 16.69897 ZIF268
    3 View Details [393..447] deduced N/A No confident structure predictions are available.
    4 View Details [448..568] PSI-BLAST 20.522879 Designed zinc finger protein


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle