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Protein Overview: l(1)dd4-PA

General Information:
Name(s) found: l(1)dd4-PA / FBpp0073672 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene lethal (1) discs degenerate 4 is referred to in FlyBase by the symbol Dmel\l(1)dd4 (CG10988, FBgn0001612). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13630600..13638688. It has the cytological map location 12B4. There is experimental evidence that it has the molecular function</span>: microtubule minus-end binding; gamma-tubulin binding. There is experimental evidence that it is involved in the biological process</span>: centrosome organization; anaphase; meiosis; microtubule nucleation; mitotic spindle organization; meiosis I. 19 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: cytoplasmic part; nervous system; peripheral nervous system; organ system; centrosome; cell cycle; adult segment; adult mesothoracic segment; intracellular organelle part; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 917 amino acids

    Gene Ontology:
    Cellular Component: gamma-tubulin small complex [IDA][IPI][NAS]
    microtubule associated complex [ISS]
    Biological Process: anaphase [IMP]
    centrosome organization [IMP]
    mitotic spindle organization [IMP]
    microtubule nucleation [IDA]
    meiosis [IMP]
    microtubule-based process [ISS]
    meiosis I [IMP]
    Molecular Function: microtubule minus-end binding [IDA]
    gamma-tubulin binding [IDA]
    microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDRIAGID VATNSTDISN IINEMIICIK GKQMPEVHEK AMDHLSKMIA ANSRVIRDSN  60
   61 MLTERECVQK IMKLLSARNK KEEGKTVSDH FNELYRKLTL TKCDPHMRHS LMTHLLTMTD 120
  121 NSDAEKAVAS EDPRTQCDNL TQILVSRLNS ISSSIASLNE MGVVNGNGVG AAAVTGAAAV 180
  181 TGAAAVTGAA AVTGAAASHS YDATQSSIGL RKQSLPNYLD ATKMLPESRH DIVMSAIYSF 240
  241 TGVQGKYLKK DVVTGRFKLD QQNIKFLTTG QAGMLLRLSE LGYYHDRVVK FSDVSTGFNA 300
  301 IGSMGQALIS KLKEELANFH GQVAMLHDEM QRFRQASVNG IANKGKKDSG PDAGDEMTLF 360
  361 KLLAWYIKPL HRMQWLTKIA DACQVKKGGD LASTVYDFLD NGNDMVNKLV EDLLTAICGP 420
  421 LVRMISKWIL EGGISDMHRE FFVKSIKDVG VDRLWHDKFR LRLPMLPKFV PMDMANKILM 480
  481 TGKSINFLRE ICEEQGMMKE RDELMKVMES SASQIFSYTP DTSWHAAVET CYQQTSKHVL 540
  541 DIMVGPHKLL DHLHGMRRYL LLGQGDFISI LIENMKNELE RPGLDIYAND LTSMLDSALR 600
  601 CTNAQYDDPD ILNHLDVIVQ RPFNGDIGWN IISLQYIVHG PLAAMLESTM PTYKVLFKPL 660
  661 WRMKHMEFVL SMKIWKEQMG NAKALRTMKS EIGKASHRLN LFTSEIMHFI HQMQYYVLFE 720
  721 VIECNWVELQ KKMQKATTLD EILEAHEKFL QTILVGCFVS NKASVEHSLE VVYENIIELE 780
  781 KWQSSFYKDC FKELNARKEL SKIVEKSEKK GVYGLTNKMI LQRDQEAKIF AEKMDIACRG 840
  841 LEVIATDYEK AVSTFLMSLN SSDDPNLQLF GTRLDFNEYY KKRDTNLSKP LTFEHMRMSN 900
  901 VFAVNSRFVI CTPSTQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..263] MSA 1.156997 View MSA. No confident structure predictions are available.
    2 View Details [264..491] MSA 2.18698 View MSA. No confident structure predictions are available.
    3 View Details [492..604] deduced N/A No confident structure predictions are available.
    4 View Details [605..786] MSA 3.204989 View MSA. No confident structure predictions are available.
    5 View Details [787..917] MSA 2.186994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle