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Protein Overview: CG9940-PA, CG994...

General Information:
Name(s) found: FBpp0310009 [FlyBase]
CG9940-PA / FBpp0073676 [FlyBase]
CG9940-PB / FBpp0073675 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • type=protein; loc=X:complement(13579842..13580535,13580602..13582035,13582105..13582194,13582291..13582436); ID=FBpp0310009; name=CG9940-PC; parent=FBgn0030512,FBtr0343352; dbxref=FlyBase:FBpp0310009,FlyBase_Annotation_IDs:CG9940-PC; MD5=8e50e4d34518953ed40c9787035cd62e; length=787; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG9940 (CG9940, FBgn0030512). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13578586..13612316. It has the cytological map location 12B2-12B4. Based on sequence similarity, it is predicted to have molecular function</span>: NAD+ synthase (glutamine-hydrolyzing) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: NAD biosynthetic process. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG9940 (CG9940, FBgn0030512). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13578586..13612316. It has the cytological map location 12B2-12B4. Based on sequence similarity, it is predicted to have molecular function</span>: NAD+ synthase (glutamine-hydrolyzing) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: NAD biosynthetic process. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 787 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NAD biosynthetic process [IEA][ISS]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [IEA]
    NAD+ synthase (glutamine-hydrolyzing) activity [IEA][ISS]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRKVTVAVS TLNQWALDFE GNMVRILQSI LEAKDMGASY RTGPELEVCG YSCEDHFREP  60
   61 DTFLHSWEVL LEVMMSPMCE NMLVDVGMPV MHRNVAYNCR VAFFNRQILL IRPKMAMCDD 120
  121 GNYRESRWFT AWTKALQTEE YVLPRMIAQH TGQQTVPFGD AVIATRDTCL GYEICEELWN 180
  181 VRSKHIEMSL AGVELIVNSS GSYMELRKAH ITSDLIRNAS FKAGGAYLFS NLRGCDGQRV 240
  241 YFNGCSAIAL NGEILARSQQ FALQDVEVTL ATIDLEEIRA YRVSLRSRCT AAASAAEYPR 300
  301 IHCDFEMSTH SDIFKTSTPP LNWPMHTPEE EIALGPACWL WDYLRRSGQG GFFLPLSGGV 360
  361 DSSSSATIVH SMCRQIVQAV QQGDAQVLHD IRQLLADSDY TPDNAAGLCN RLLVTCYMGS 420
  421 VNSSKETRRR AAQLANQLGS YHIEISIDSA VNALLSIFNA VTGLTPRFRT QGGCARQNLA 480
  481 LQNMQSRIRM VLAYIFAQLT LWVRNRPGGL LVLGSANVDE SLRGYLTKYD CSSADINPIG 540
  541 GISKMDLRRF LTYAKDKFNL PVLESIIDAP PTAELEPLQE NGELQQTDEA DMGMTYAELS 600
  601 QFGRLRKQSF CGPYSMFCHL VATWKSDLSP KEVAEKVKHF FLCYAINRHK MTVLTPSVHA 660
  661 ESYSPDDNRF DHRPFLYRPN WSWQFKAIDD EAEKLQPIYT PSSAQLRPSS EDLLISTQRS 720
  721 SHLDDSKHSS PLSSASASAS IDVGISTAAV PLPGAAAPGG LSKKPSGYSK VHVNVLGKIK 780
  781 DRTGIPV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..382] PSI-BLAST 56.0 NIT-FHIT fusion protein, C-terminal domain; NIT-FHIT fusion protein, N-terminal domain
    2 View Details [383..672] PSI-BLAST 60.221849 NH3-dependent NAD+-synthetase
    3 View Details [673..787] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.8930848757764 bayes_pls_golite062009
  • catalytic activity
    		•  1.64442398754697 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.35962310800332 bayes_pls_golite062009
  • binding
    		•  1.19055167016953 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.724655038971066 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.9422825865652 bayes_pls_golite062009
  • ligase activity
    		•  1.91098844584143 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.77152913449838 bayes_pls_golite062009
  • GMP synthase (glutamine-hydrolyzing) activity
    		•  1.08094655947236 bayes_pls_golite062009
  • catalytic activity
    		•  0.828867994386867 bayes_pls_golite062009
  • binding
    		•  0.752095595503409 bayes_pls_golite062009
  • NAD+ synthase activity
    		•  0.693146657234538 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.625929821763467 bayes_pls_golite062009
  • DNA binding
    		•  0.578102940811233 bayes_pls_golite062009
  • hydrolase activity
    		•  0.180852708655017 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle