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Protein Overview: up-PA

General Information:
Name(s) found: up-PA / FBpp0073682 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene upheld is referred to in FlyBase by the symbol Dmel\up (CG7107, FBgn0004169). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13487610..13496536. It has the cytological map location 12A7. There is experimental evidence that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: cellular calcium ion homeostasis; myofibril assembly; muscle organ morphogenesis; muscle homeostasis; sarcomere organization; mitochondrion organization; muscle thin filament assembly; mesoderm development. 15 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; adult mesothoracic segment; cytoplasmic part; contractile fiber part; indirect flight muscle; adult somatic muscle; sarcomere; organ system; cuticle; protein complex. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 397 amino acids

    Gene Ontology:
    Cellular Component: striated muscle thin filament [IDA]
    troponin complex [ISS][NAS]
    Biological Process: myofibril assembly [IMP]
    muscle cell homeostasis [IMP]
    skeletal muscle thin filament assembly [IMP]
    sarcomere organization [IMP]
    mesoderm development [IEP]
    muscle organ morphogenesis [IMP]
    mitochondrion organization [IMP]
    cellular calcium ion homeostasis [IMP]
    Molecular Function: calcium ion binding [IDA]
    tropomyosin binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDDEEYTSS EEEEVVEETR EETKPPQTPA EGEGDPEFIK RQDQKRSDLD DQLKEYITEW  60
   61 RKQRSKEEDE LKKLKEKQAK RKVTRAEEEQ KMAQRKKEEE ERRVREAEEK KQREIEEKRM 120
  121 RLEEAEKKRQ AMLQAMKDKD KKGPNFTIAK KDAGVLGLSS AAMERNKTKE QLEEEKKISL 180
  181 SFRIKPLAIE GFGEAKLREK AQELWELIVK LETEKYDLEE RQKRQDYDLK ELKERQKQQL 240
  241 RHKALKKGLD PEALTGKYPP KIQVASKYER RVDTRSYDDK KKLFEGGWDE ISKDSNEKIW 300
  301 NEKKEQYTGR QKSKLPKWFG ERPGKKAGEP ETPEGEEDAK ADEDIVEDDE EVEEEVVEEE 360
  361 DEEAEEDEEE EEEEEEEEEE EEEEEEEEEE EEEEEEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..397] PSI-BLAST 21.0 Heavy meromyosin subfragment


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle