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Protein Overview: alpha-Man-I-PJ, ...

General Information:
Name(s) found: alpha-Man-I-PO / FBpp0289743 [FlyBase]
alpha-Man-I-PN / FBpp0289742 [FlyBase]
alpha-Man-I-PM / FBpp0289741 [FlyBase]
alpha-Man-I-PL / FBpp0289740 [FlyBase]
alpha-Man-I-PJ / FBpp0289738 [FlyBase]
alpha-Man-I-PH / FBpp0288907 [FlyBase]
Description(s) found:
Found 85 descriptions.
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  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene Ã?&#142;Ã?± Mannosidase I is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Man-I (CG42275, FBgn0259170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10170088..10219990. It has the cytological map location 9B6. Based on sequence similarity, it is predicted to have molecular function</span>: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan. 38 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; peripheral nervous system; ommatidium. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 667 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Golgi apparatus [ISS]
    Golgi membrane [NAS]
    Biological Process: determination of adult lifespan [IMP]
    protein amino acid N-linked glycosylation [ISS][NAS]
    Molecular Function: calcium ion binding [IEA]
    mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRISPIGRK SNFHSREKCL IGLVLVTLCF LCFGGIFLLP DNFGSDRVLR VYKHFRKAGP  60
   61 EIFIPAPPLA AHAPHRSEDP HFIGDRQRLE QKIRAELGDM LDEPPAAGGG EPGQFQVLAQ 120
  121 QAQAPAPVAA LADQPLDQDE GHAAIPVLAA PVQGDNAASQ ASSHPQSSAQ QHNQQQPQLP 180
  181 LGGGGNDQAP DTLDATLEER RQKVKEMMEH AWHNYKLYAW GKNELRPLSQ RPHSASIFGS 240
  241 YDLGATIVDG LDTLYIMGLE KEYREGRDWI ERKFSLDNIS AELSVFETNI RFVGGMLTLY 300
  301 AFTGDPLYKE KAQHVADKLL PAFQTPTGIP YALVNTKTGV AKNYGWASGG SSILSEFGTL 360
  361 HLEFAYLSDI TGNPLYRERV QTIRQVLKEI EKPKGLYPNF LNPKTGKWGQ LHMSLGALGD 420
  421 SYYEYLLKAW LQSGQTDEEA REMFDEAMLA ILDKMVRTSP GGLTYVSDLK FDRLEHKMDH 480
  481 LACFSGGLFA LGAATRQNDY TDKYMEVGKG ITNTCHESYI RAPTQLGPEA FRFSEAVEAR 540
  541 ALRSQEKYYI LRPETFESYF VLWRLTHDQK YRDWGWEAVL ALEKHCRTAH GYCGLRNVYQ 600
  601 QEPQKDDVQQ SFFLAETLKY LYLLFSDDSV LPLDEWVFNT EAHPLPIKGA NAYYRQAPVT 660
  661 LPVSNAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] MSA 5.175995 View MSA. No confident structure predictions are available.
    2 View Details [176..667] PSI-BLAST 1000.0 Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mannosyl-oligosaccharide mannosidase activity
    		•  7.089685350864 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
    		•  6.95179264736435 bayes_pls_golite062009
  • mannosidase activity
    		•  5.20286438265852 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.31319275372149 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.65589746311782 bayes_pls_golite062009
  • hydrolase activity
    		•  2.67964748309919 bayes_pls_golite062009
  • binding
    		•  1.49199031708525 bayes_pls_golite062009
  • catalytic activity
    		•  1.31873306707813 bayes_pls_golite062009
  • cation binding
    		•  0.362242764130218 bayes_pls_golite062009
  • metal ion binding
    		•  0.362242764130218 bayes_pls_golite062009
  • protein binding
    		•  0.36081692928767 bayes_pls_golite062009
  • ion binding
    		•  0.355220167272296 bayes_pls_golite062009
  • calcium ion binding
    		•  0.121126738064555 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle